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INDOMETHACIN SODIUM SALT TRIHYDRATE

Product Name
INDOMETHACIN SODIUM SALT TRIHYDRATE
CAS No.
74252-25-8
Chemical Name
INDOMETHACIN SODIUM SALT TRIHYDRATE
Synonyms
Indometacin Sodium;INDOMETACIN FARNESIL;Sodium salt trihydrate;Indomethacin sodium hydrate;Indomethacin sodium trihydrate;Indomethacin sodium salt 3-hydrate;INDOMETHACIN SODIUM SALT TRIHYDRATE;Indomethacin (Indometacin) sodium hydrateis;sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
CBNumber
CB81012013
Molecular Formula
C34H40ClNO4
Formula Weight
562.146
MOL File
74252-25-8.mol
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INDOMETHACIN SODIUM SALT TRIHYDRATE Property

storage temp. 
4°C, protect from light, stored under nitrogen
solubility 
DMSO: 5 mg/mL (11.53 mM)
form 
Solid
color 
Light yellow to yellow
Water Solubility 
Water: 33.33 mg/mL (76.83 mM)
InChIKey
CFIGYZZVJNJVDQ-LMJOQDENSA-N
SMILES
C12C=CC(OC)=CC=1C(=C(C)N2C(=O)C1C=CC(Cl)=CC=1)CC(=O)OC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0089425
Product name
Indomethacinsodiumhydrate
Packaging
500mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0089425
Product name
Indomethacinsodiumhydrate
Packaging
1g
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016899
Product name
INDOMETHACIN SODIUM SALT TRIHYDRATE
Purity
95.00%
Packaging
5MG
Price
$501
Updated
2021/12/16
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INDOMETHACIN SODIUM SALT TRIHYDRATE Chemical Properties,Usage,Production

Uses

Anti-inflammatory.

brand name

Indocin (Ovation).

Hazard

A poison by ingestion.

in vivo

Indomethacin sodium hydrate can be used to create gastric ulcer models. After oral administration, the drug is absorbed rapidly and completely, although there are interindividual and intraindividual variations. The plasma peak concentration of 2-3 μg/mL is typically reached within 1-2 hours. However, coadministration with food reduces and delays the peak concentration without affecting the total absorption. At therapeutic concentrations, 90% of Indomethacin is bound to albumin in the plasma[4].

Induction of gastric ulceration[5][6]
Background
Indomethacin can cause gastric ulceration by various mechanisms, including injury through inhibition of prostaglandin (PG) synthesis, reduction in local blood flow, regional irritation, and inhibition of tissue regeneration.
Specific Modeling Methods
Rat: albino Sprague-Dawley ? male ? adult (period: 2 weeks)
Administration: 100 mg/kg ? p.o. ? single dose
Note
(1) All animals fasted 24 h before drug administration.
(2) Indomethacin were dissolved in saline with 5% NaOH.
Modeling Indicators
Gastric tissue macroscopic alterations: Showed prominent mucosal folds and severe erosion, pronounced ulceration and bleeding foci in the gastric mucosa.
Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
Molecular changes: Showed intense Tnf-α expression.
Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.
Correlated Product(s): Indomethacin sodium hydrate (HY-14397A)
Opposite Product(s): Carnosic acid (HY-N0644)

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.01-10 mg/kg
Administration:Oral administration; for 3 hours
Result:Inhibited the carrageenan-induced rat paw oedema (ED50=2.0?mg/kg) and hyperalgesia (ED50=1.5?mg/kg) in a dose-dependent manner.
Animal Model:Male C57BL/6J mice[2]
Dosage:10 mg/mL
Administration:Oral administration; daily, for 29 days
Result:Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.

INDOMETHACIN SODIUM SALT TRIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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INDOMETHACIN SODIUM SALT TRIHYDRATE Suppliers

China 94 India 2 United States 7 Global 103
Jiangxi ravel Biotechnology Co.,Ltd
Tel
400-880-2824 18107960669
Fax
18140514863
Email
79046690@qq.com
Country
China
ProdList
1242
Advantage
58
Jinan Jinchi Pharmaceutical Technology Co., LTD
Tel
15168890063 18888326116
Email
76337143@qq.com
Country
China
ProdList
64
Advantage
58
Hubei Yuanmeng Biotechnology Co., Ltd
Tel
027-68897569 18120462897
Fax
027-68897569
Email
fiona@yuanmengbio.com
Country
China
ProdList
4657
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58
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
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52
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
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50
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Shenzhen Simeiquan Biotechnology Co. Ltd
Tel
18126413629 0755-23311925 2355327053
Fax
0755-23311925
Email
abel@ycgmp.com
Country
China
ProdList
5113
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Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1676
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
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58
Shenzhen Sendi Biological Technology Co., Ltd.
Tel
18124570582 TEL：0755-23574479 2355327139
Fax
0755-23229476 QQ: 2355327139
Email
siliao02@yccreate.com
Country
China
ProdList
6116
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View Lastest Price from INDOMETHACIN SODIUM SALT TRIHYDRATE manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
INDOMETHACIN SODIUM SALT TRIHYDRATE 74252-25-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
1tons
Release date
2024-04-26
Hebei Zhanyao Biotechnology Co. Ltd
Product
Indometacin sodium 74252-25-8
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-22

74252-25-8, INDOMETHACIN SODIUM SALT TRIHYDRATERelated Search:

CINIDON-ETHYL Indometacin Indoline-2-carboxylic acid Indobufen Indole-3-carbinol Indole (-)-INDOLACTAM V Indazole-3-carboxylic acid 5-Methoxyindole-3-acetic acid Ethyl 3-indoleacetate (E,E)-Farnesol 5-METHOXYTRYPTOPHOL 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Delmetacin INDOMETHACIN SODIUM SALT TRIHYDRATE 2-METHYLINDOLE-3-ACETIC ACID FARNESYL ACETATE INDOLE-3-ACETIC ACID

  • INDOMETHACIN SODIUM SALT TRIHYDRATE
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
  • INDOMETACIN FARNESIL
  • 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt, hydrate (1:1:3)
  • Indometacin Sodium
  • Sodium salt trihydrate
  • sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate
  • Indomethacin sodium hydrate
  • Indomethacin sodium salt 3-hydrate
  • Indomethacin sodium trihydrate
  • Indomethacin (Indometacin) sodium hydrateis
  • 74252-25-8
  • C19H21ClNNaO7