ChemicalBook > CAS DataBase List > INDOMETHACIN SODIUM SALT TRIHYDRATE

INDOMETHACIN SODIUM SALT TRIHYDRATE

Product Name: INDOMETHACIN SODIUM SALT TRIHYDRATE
CAS No.: 74252-25-8
Chemical Name: INDOMETHACIN SODIUM SALT TRIHYDRATE
Synonyms: Indometacin Sodium;INDOMETACIN FARNESIL;Sodium salt trihydrate;Indomethacin sodium hydrate;Indomethacin sodium trihydrate;Indomethacin sodium salt 3-hydrate;INDOMETHACIN SODIUM SALT TRIHYDRATE;Indomethacin (Indometacin) sodium hydrateis;sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
CBNumber: CB81012013
Molecular Formula: C34H40ClNO4
Formula Weight: 562.146
MOL File: 74252-25-8.mol

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INDOMETHACIN SODIUM SALT TRIHYDRATE Property

storage temp.: 4°C, protect from light, stored under nitrogen
solubility: DMSO: 5 mg/mL (11.53 mM)
form: Solid
color: Light yellow to yellow
Water Solubility: Water: 33.33 mg/mL (76.83 mM)
InChIKey: CFIGYZZVJNJVDQ-LMJOQDENSA-N
SMILES: C12C=CC(OC)=CC=1C(=C(C)N2C(=O)C1C=CC(Cl)=CC=1)CC(=O)OC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0089425
Product name: Indomethacinsodiumhydrate
Packaging: 500mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0089425
Product name: Indomethacinsodiumhydrate
Packaging: 1g
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016899
Product name: INDOMETHACIN SODIUM SALT TRIHYDRATE
Purity: 95.00%
Packaging: 5MG
Price: $501
Updated: 2021/12/16

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INDOMETHACIN SODIUM SALT TRIHYDRATE Chemical Properties,Usage,Production

Uses

Anti-inflammatory.

brand name

Indocin (Ovation).

Hazard

A poison by ingestion.

in vivo

Indomethacin sodium hydrate can be used to create gastric ulcer models. After oral administration, the drug is absorbed rapidly and completely, although there are interindividual and intraindividual variations. The plasma peak concentration of 2-3 μg/mL is typically reached within 1-2 hours. However, coadministration with food reduces and delays the peak concentration without affecting the total absorption. At therapeutic concentrations, 90% of Indomethacin is bound to albumin in the plasma^[4].

Induction of gastric ulceration^[5]^[6]

Background

Indomethacin can cause gastric ulceration by various mechanisms, including injury through inhibition of prostaglandin (PG) synthesis, reduction in local blood flow, regional irritation, and inhibition of tissue regeneration.

Specific Modeling Methods

Rat: albino Sprague-Dawley ? male ? adult (period: 2 weeks)
Administration: 100 mg/kg ? p.o. ? single dose

Note

(1) All animals fasted 24 h before drug administration.
(2) Indomethacin were dissolved in saline with 5% NaOH.

Modeling Indicators

Gastric tissue macroscopic alterations: Showed prominent mucosal folds and severe erosion, pronounced ulceration and bleeding foci in the gastric mucosa.
Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
Molecular changes: Showed intense Tnf-α expression.
Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.

Correlated Product(s): Indomethacin sodium hydrate (HY-14397A)

Opposite Product(s): Carnosic acid (HY-N0644)

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	0.01-10 mg/kg
Administration:	Oral administration; for 3 hours
Result:	Inhibited the carrageenan-induced rat paw oedema (ED₅₀=2.0?mg/kg) and hyperalgesia (ED₅₀=1.5?mg/kg) in a dose-dependent manner.

Animal Model:	Male C57BL/6J mice^[2]
Dosage:	10 mg/mL
Administration:	Oral administration; daily, for 29 days
Result:	Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.

INDOMETHACIN SODIUM SALT TRIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from INDOMETHACIN SODIUM SALT TRIHYDRATE manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: INDOMETHACIN SODIUM SALT TRIHYDRATE 74252-25-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

Hebei Zhanyao Biotechnology Co. Ltd

Product: Indometacin sodium 74252-25-8
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-22

74252-25-8, INDOMETHACIN SODIUM SALT TRIHYDRATERelated Search:

CINIDON-ETHYL Indometacin Indoline-2-carboxylic acid Indobufen Indole-3-carbinol Indole (-)-INDOLACTAM V Indazole-3-carboxylic acid 5-Methoxyindole-3-acetic acid Ethyl 3-indoleacetate (E,E)-Farnesol 5-METHOXYTRYPTOPHOL 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Delmetacin INDOMETHACIN SODIUM SALT TRIHYDRATE 2-METHYLINDOLE-3-ACETIC ACID FARNESYL ACETATE INDOLE-3-ACETIC ACID

INDOMETHACIN SODIUM SALT TRIHYDRATE

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate

INDOMETACIN FARNESIL

1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt, hydrate (1:1:3)

Indometacin Sodium

Sodium salt trihydrate

sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate

Indomethacin sodium hydrate

Indomethacin sodium salt 3-hydrate

Indomethacin sodium trihydrate

Indomethacin (Indometacin) sodium hydrateis

74252-25-8

C19H21ClNNaO7