4-Hydroxyindole
- Product Name
- 4-Hydroxyindole
- CAS No.
- 2380-94-1
- Chemical Name
- 4-Hydroxyindole
- Synonyms
- 1H-INDOL-4-OL;4-Hdroxyindole;4-INDOLOL;INDOL-4-OL;1H-INDOLE-4-OL;4-HydroxyindoL;4-HYDROXYINDOLE;4-Hydroxxyindole;4-Hydroxylndole;4-Hydroxyindole>
- CBNumber
- CB5663260
- Molecular Formula
- C8H7NO
- Formula Weight
- 133.15
- MOL File
- 2380-94-1.mol
4-Hydroxyindole Property
- Melting point:
- 97-99 °C(lit.)
- Boiling point:
- 245.66°C (rough estimate)
- Density
- 1.1475 (rough estimate)
- vapor pressure
- 0.019Pa at 25℃
- refractive index
- 1.5260 (estimate)
- storage temp.
- 0-6°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.89±0.40(Predicted)
- color
- Dark Yellow to Green-Grey
- Water Solubility
- slightly soluble
- Sensitive
- Air Sensitive
- BRN
- 114905
- InChIKey
- NLMQHXUGJIAKTH-UHFFFAOYSA-N
- LogP
- 1.57 at 25℃
- CAS DataBase Reference
- 2380-94-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 219878
- Product name
- 4-Hydroxyindole
- Purity
- 99%
- Packaging
- 1g
- Price
- $62.9
- Updated
- 2024/03/01
- Product number
- 1327157
- Product name
- 4-Hydroxyindole
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25MG
- Price
- $1170
- Updated
- 2024/03/01
- Product number
- H0582
- Product name
- 4-Hydroxyindole
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- H0582
- Product name
- 4-Hydroxyindole
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $179
- Updated
- 2021/12/16
- Product number
- L14352
- Product name
- 4-Hydroxyindole, 98%
- Packaging
- 1g
- Price
- $18.65
- Updated
- 2024/03/01
4-Hydroxyindole Chemical Properties,Usage,Production
Chemical Properties
Off-White Cyrstalline Solid
Uses
4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.
Definition
ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.
Application
4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.
Preparation
Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.
General Description
Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.
4-Hydroxyindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxyindole manufacturers
- Product
- 4-Hydroxyindole 2380-94-1
- Price
- US $13.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 200ton
- Release date
- 2024-06-19
- Product
- 4-Hydroxyindole 2380-94-1
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
- Product
- 4-Hydroxyindole 2380-94-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-09