ChemicalBook > CAS DataBase List > 4-Hydroxyindole

4-Hydroxyindole

Product Name
4-Hydroxyindole
CAS No.
2380-94-1
Chemical Name
4-Hydroxyindole
Synonyms
1H-INDOL-4-OL;4-Hdroxyindole;4-INDOLOL;INDOL-4-OL;1H-INDOLE-4-OL;4-HydroxyindoL;4-HYDROXYINDOLE;4-Hydroxxyindole;4-Hydroxylndole;4-Hydroxyindole>
CBNumber
CB5663260
Molecular Formula
C8H7NO
Formula Weight
133.15
MOL File
2380-94-1.mol
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4-Hydroxyindole Property

Melting point:
97-99 °C(lit.)
Boiling point:
245.66°C (rough estimate)
Density 
1.1475 (rough estimate)
vapor pressure 
0.019Pa at 25℃
refractive index 
1.5260 (estimate)
storage temp. 
0-6°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.89±0.40(Predicted)
color 
Dark Yellow to Green-Grey
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive
BRN 
114905
InChIKey
NLMQHXUGJIAKTH-UHFFFAOYSA-N
LogP
1.57 at 25℃
CAS DataBase Reference
2380-94-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
IRRITANT, KEEP COLD
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219878
Product name
4-Hydroxyindole
Purity
99%
Packaging
1g
Price
$62.9
Updated
2024/03/01
Sigma-Aldrich
Product number
1327157
Product name
4-Hydroxyindole
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25MG
Price
$1170
Updated
2024/03/01
TCI Chemical
Product number
H0582
Product name
4-Hydroxyindole
Purity
>99.0%(GC)
Packaging
5g
Price
$51
Updated
2021/12/16
TCI Chemical
Product number
H0582
Product name
4-Hydroxyindole
Purity
>99.0%(GC)
Packaging
25g
Price
$179
Updated
2021/12/16
Alfa Aesar
Product number
L14352
Product name
4-Hydroxyindole, 98%
Packaging
1g
Price
$18.65
Updated
2024/03/01
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4-Hydroxyindole Chemical Properties,Usage,Production

Chemical Properties

Off-White Cyrstalline Solid

Uses

4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.

Definition

ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.

Application

4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.

Preparation

Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.

General Description

Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.

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4-Hydroxyindole Suppliers

Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
0519-85269522 13660798926
Fax
013660798926
Email
sunlight68@126.com
Country
China
ProdList
100
Advantage
60
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1788
Advantage
58
Zhejiang Zetian Fine Chemical Co., Ltd
Tel
0571-0571-87682782 18957127338
Fax
QQ:3007632051
Email
sales@zetchem.com
Country
China
ProdList
478
Advantage
58
Jiaxing Zhonghui Biotechnology Co. Ltd
Tel
17324007174
Email
jiangfeng2016@126.com
Country
China
ProdList
45
Advantage
55
Shandong Jiuyue Biological Technology Co., LTD
Tel
15553348166
Email
m15553348166@163.com
Country
China
ProdList
3465
Advantage
58
Suzhou Chukai PharmaTech
Tel
0512-88812066
Fax
86-512-63926099
Email
wenlongfcb@qq.com
Country
China
ProdList
113
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Changzhou Sunlight Pharmaceutical Co., Ltd
Tel
0519-83131668 15995063688
Fax
+86-519-83138041
Email
info@sunlightchem.com
Country
China
ProdList
99
Advantage
69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
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View Lastest Price from 4-Hydroxyindole manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-Hydroxyindole 2380-94-1
Price
US $122.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-11
Hebei Yanxi Chemical Co., Ltd.
Product
4-Hydroxyindole 2380-94-1
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-20
Hebei Lingding Biotechnology Co., Ltd.
Product
4-Hydroxyindole 2380-94-1
Price
US $100.00-42.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-12-07

2380-94-1, 4-HydroxyindoleRelated Search:


  • 4-Hdroxyindole
  • 4-Hydroxyindole in stock Factory
  • 1H-INDOL-4-OL
  • 1H-INDOLE-4-OL
  • 4-HYDROXY-1H-INDOLE
  • 4-INDOLOL
  • 4-HYDROXYINDOLE
  • INDOL-4-OL
  • 4-Hydroxy Indole (4-Indolol)
  • 4-Hydroxxyindole
  • 4-Hydroxyindole>99.0%
  • 4-Hydroxyindole,98%
  • 4-Hydroxylndole
  • 4-HYDROXYINDOLE(4OHI)
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  • 1H-indol-4-ol, 4- hydroxyindole
  • 4-Hydroxyindole≥ 99.5% (HPLC)
  • 1,5-Dihydro-indol-4-one
  • Pindolol EP Impurity E
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  • 1H-Indol-4-ol (9CI, ACI)
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  • 4-Hydroxyindole (25 mg) (1H-Indol-4-ol)
  • 2380-94-1
  • Simple Indoles
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  • ALCOHOL
  • Heterocyclic Building Blocks
  • API
  • Chemical
  • Heterocycle-Indole series
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  • Pyrroles & Indoles
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  • 2380-94-1