4-Hydroxyindole

Product Name: 4-Hydroxyindole
CAS No.: 2380-94-1
Chemical Name: 4-Hydroxyindole
Synonyms: 1H-INDOL-4-OL;4-Hdroxyindole;4-INDOLOL;INDOL-4-OL;1H-INDOLE-4-OL;4-HydroxyindoL;4-HYDROXYINDOLE;4-Hydroxxyindole;4-Hydroxylndole;4-Hydroxyindole>
CBNumber: CB5663260
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 2380-94-1.mol

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4-Hydroxyindole Property

Melting point:: 97-99 °C(lit.)
Boiling point:: 245.66°C (rough estimate)
Density: 1.1475 (rough estimate)
vapor pressure: 0.019Pa at 25℃
refractive index: 1.5260 (estimate)
storage temp.: 0-6°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.89±0.40(Predicted)
color: Dark Yellow to Green-Grey
Water Solubility: slightly soluble
Sensitive: Air Sensitive
BRN: 114905
InChIKey: NLMQHXUGJIAKTH-UHFFFAOYSA-N
LogP: 1.57 at 25℃
CAS DataBase Reference: 2380-94-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, KEEP COLD
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219878
Product name: 4-Hydroxyindole
Purity: 99%
Packaging: 1g
Price: $62.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1327157
Product name: 4-Hydroxyindole
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25MG
Price: $1170
Updated: 2024/03/01

TCI Chemical

Product number: H0582
Product name: 4-Hydroxyindole
Purity: >99.0%(GC)
Packaging: 5g
Price: $51
Updated: 2021/12/16

TCI Chemical

Product number: H0582
Product name: 4-Hydroxyindole
Purity: >99.0%(GC)
Packaging: 25g
Price: $179
Updated: 2021/12/16

Alfa Aesar

Product number: L14352
Product name: 4-Hydroxyindole, 98%
Packaging: 1g
Price: $18.65
Updated: 2024/03/01

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4-Hydroxyindole Chemical Properties,Usage,Production

Chemical Properties

Off-White Cyrstalline Solid

Uses

4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.

Definition

ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.

Application

4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.

Preparation

Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.

General Description

Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.

4-Hydroxyindole Preparation Products And Raw materials

Raw materials

Methanol solution Ethyl bromopyruvate 2,6-Dinitrotoluene tert-Butanol Paraformaldehyde Resorcinol Indole N,N-Dimethylacetamide

Preparation Products

4-(oxiranylmethoxy)-1H-indole Pindolol 4-HO-DET

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4-Hydroxyindole Suppliers

Americas 1 Belgium 2 Canada 3 China 407 Europe 3 Germany 6 India 23 Japan 5 Slovakia 1 South Korea 2 Switzerland 6 Ukraine 1 United Kingdom 22 United States 75 Global 557

Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.

Tel: 0519-85269522 13660798926
Fax: 013660798926
Email: sunlight68@126.com
Country: China
ProdList: 99
Advantage: 60

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 15523000485
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1686
Advantage: 58

Zhejiang Zetian Fine Chemical Co., Ltd

Tel: 0571-87682782 18957127338
Fax: QQ:3007632051
Email: sales@zetchem.com
Country: China
ProdList: 476
Advantage: 58

Jiaxing Zhonghui Biotechnology Co. Ltd

Tel: 17324007174
Email: jiangfeng2016@126.com
Country: China
ProdList: 58
Advantage: 55

Shandong Jiuyue Biological Technology Co., LTD

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 3538
Advantage: 58

Suzhou Chukai PharmaTech

Tel: 0512-88812066
Fax: 86-512-63926099
Email: wenlongfcb@qq.com
Country: China
ProdList: 327
Advantage: 58

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 964
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Changzhou Sunlight Pharmaceutical Co., Ltd

Tel: 0519-83131668 15995063688
Fax: +86-519-83138041
Email: info@sunlightchem.com
Country: China
ProdList: 99
Advantage: 69

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

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View Lastest Price from 4-Hydroxyindole manufacturers

Hebei Ganmiao New material Technology Co., LTD

Product: 4-Hydroxyindole 2380-94-1
Price: US $13.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200ton
Release date: 2024-06-19

Henan Fengda Chemical Co., Ltd

Product: 4-Hydroxyindole 2380-94-1
Price: US $122.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-11

LY Global chemicals co.,ltd .

Product: 4-Hydroxyindole 2380-94-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-09

2380-94-1, 4-HydroxyindoleRelated Search:

Indole-3-acetic acid Indometacin Protocatechuic acid Indole-3-butyric acid Pindolol 2-Methylcyclohexylamine 4,4'-Oxydianiline Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate 1-Chloro-3-(1H-indol-4-yloxy)-2-propanol 4-Benzyloxyindole-3-carboxaldehyde METHYL 4-METHOXY-2-INDOLECARBOXYLATE 4-Methoxyindole-3-carboxaldehyde 3-HYDROXYINDOLE 4-Methoxyindole PSILOCIN 4-Benzyloxyindole 7-HYDROXYINDOLE-2-CARBOXYLIC ACID 4-Hydroxy-2-methylindole

4-Hdroxyindole

4-Hydroxyindole in stock Factory

1H-INDOL-4-OL

1H-INDOLE-4-OL

4-HYDROXY-1H-INDOLE

4-INDOLOL

4-HYDROXYINDOLE

INDOL-4-OL

4-Hydroxy Indole (4-Indolol)

4-Hydroxxyindole

4-Hydroxyindole>99.0%

4-Hydroxyindole,98%

4-Hydroxylndole

4-HYDROXYINDOLE(4OHI)

4-Hydroxyindole,99%

4-Hydroxyindole , 99.0%(GC)

1H-indol-4-ol, 4- hydroxyindole

4-Hydroxyindole≥ 99.5% (HPLC)

1,5-Dihydro-indol-4-one

Pindolol EP Impurity E

4-Hydroxyindole&gt

4-HydroxyindoL

1H-Indol-4-ol (9CI, ACI)

4 Hydroxyindole,4Hydroxyindole

Pindolol Impurity E

4-Hydroxyindole (25 mg) (1H-Indol-4-ol)

4-Hydroxyindole (Standard)

2380-94-1

Simple Indoles

Indoles

Building Blocks

ALCOHOL

Heterocyclic Building Blocks

API

Chemical

Heterocycle-Indole series

Indole

Indoles

Indole Derivatives

Simple Indoles

Chiral Compound

Pyrroles & Indoles

Heterocycles

blocks

IndolesOxindoles

Indoles and derivatives

pharmacetical

Heterocycles series

Pyrroles & Indoles

bc0001

2380-94-1