Bopindolol

Product Name: Bopindolol
CAS No.: 62658-63-3
Chemical Name: Bopindolol
Synonyms: Bopindolol;rac Bopindolol;Bopindolol USP/EP/BP;1-(tert-ButylaMino)-3-((2-Methyl-1H-indol-4-yl)oxy)propan-2-yl benzoate;2-[(1,1-Dimethylethyl)amino]-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate;1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol 2-Benzoate;2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, 2-benzoate;2-PROPANOL, 1-[(1,1-DIMETHYLETHYL)AMINO]-3-[(2-METHYL-1H-INDOL-4-YL)OXY]-, BENZOATE (ESTER);(±)-1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol Benzoate (Ester)
CBNumber: CB8294403
Molecular Formula: C23H28N2O3
Formula Weight: 380.48
MOL File: 62658-63-3.mol

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Bopindolol Property

Melting point:: 117-120°C
Boiling point:: 557.0±50.0 °C(Predicted)
Density: 1.143±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka: 17.59±0.30(Predicted)
form: Solid
color: White to Pale Beige

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Safety

Toxicity: LD50 i.v. in mice: 17 mg/kg (Troxler, Seemann, 1977)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B675400
Product name: racBopindolol
Packaging: 5mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: C962
Product name: Bopindolol
Packaging: 1mg
Price: $191
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB37307
Product name: Bopindolol
Packaging: 5mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB37307
Product name: Bopindolol
Packaging: 10mg
Price: $520
Updated: 2021/12/16

AK Scientific

Product number: C962
Product name: Bopindolol
Packaging: 10mg
Price: $752
Updated: 2021/12/16

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Bopindolol Chemical Properties,Usage,Production

Description

Bopindolol is a potent, long-acting, non-selective β-adrenergic blocker related to pindolol and useful in the treatment of hypertension. Unlike many other agents of this type, it appears to have negligible effects on serum lipoproteins.

Chemical Properties

Off-White to pale Yellow Solid

Originator

sandoz (Switzerland)

Uses

Bopindolol is an ester prodrug of Pindolol (P468000). Bopindolol is a long acting β-adrenoceptor blocking agent. Bopindolol displays antispasmogenic activity mediated by α1-adrenoceptors and 5-HT2 receptors.

Definition

ChEBI: 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate is a methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group. It is a methylindole, a secondary amino compound, an aromatic ether and a benzoate ester.

Manufacturing Process

4-(2-Benzoyloxy-3-t-butylaminopropoxy)-2-methyl-indole:
26 g of benzoic acid are dissolved, while heating, in 50 ml of hexamethylphosphoric acid triamide and 3.5 g of 1-t-butylamino-3-(2-methylindole- 4-yloxy)-2-propanol are added. After cooling, 3.0 g of benzoic acid anhydride are added and stirred for 20 hours at room temperature. The resulting clear, yellow solution is poured onto ice 0.5 liters of ether are added and stirred for 2 hours. After making the liquid alkaline with concentrated ammonia, the ether phase is separated, shaken out with tartaric acid, made alkaline with caustic soda solution while cooling with ice and extracted with methylene chloride. After evaporating the solvent, the residue is crystallized with 1 mol of fumaric acid from methanol and acetone.

brand name

SANDONORM

Therapeutic Function

Beta-adrenergic blocker

Bopindolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Bopindolol Suppliers

Canada 1 China 14 Europe 2 India 1 United Kingdom 2 United States 3 Global 23

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3238
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 29016
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-18789408387
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 3487
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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
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TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31163
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24131
Advantage: 58

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View Lastest Price from Bopindolol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: rac Bopindolol 62658-63-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-11

Dideu Industries Group Limited

Product: Bopindolol 62658-63-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-12

62658-63-3, BopindololRelated Search:

Selumetinib Bisoprolol 7-(4-Bromobenzoyl)indole Pindolol 4-methoxy-2-methyl-1H-indole 4-Hydroxy-2-methylindole rac Mepindolol-d7 Bopindolol Wandonorm 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (S)- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (R)- BOPINDOLOL MALONATE

Bopindolol

2-PROPANOL, 1-[(1,1-DIMETHYLETHYL)AMINO]-3-[(2-METHYL-1H-INDOL-4-YL)OXY]-, BENZOATE (ESTER)

1-(tert-ButylaMino)-3-((2-Methyl-1H-indol-4-yl)oxy)propan-2-yl benzoate

2-[(1,1-Dimethylethyl)amino]-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate

(±)-1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol Benzoate (Ester)

1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol 2-Benzoate

rac Bopindolol

2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, 2-benzoate

Bopindolol USP/EP/BP

62658-63-3

C23H28N2O3

Aromatics

Heterocycles

Indole Derivatives

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals