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Bopindolol

Product Name
Bopindolol
CAS No.
62658-63-3
Chemical Name
Bopindolol
Synonyms
Bopindolol;rac Bopindolol;Bopindolol USP/EP/BP;1-(tert-ButylaMino)-3-((2-Methyl-1H-indol-4-yl)oxy)propan-2-yl benzoate;2-[(1,1-Dimethylethyl)amino]-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate;1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol 2-Benzoate;2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, 2-benzoate;2-PROPANOL, 1-[(1,1-DIMETHYLETHYL)AMINO]-3-[(2-METHYL-1H-INDOL-4-YL)OXY]-, BENZOATE (ESTER);(±)-1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol Benzoate (Ester)
CBNumber
CB8294403
Molecular Formula
C23H28N2O3
Formula Weight
380.48
MOL File
62658-63-3.mol
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Bopindolol Property

Melting point:
117-120°C
Boiling point:
557.0±50.0 °C(Predicted)
Density 
1.143±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka
17.59±0.30(Predicted)
form 
Solid
color 
White to Pale Beige
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Safety

Toxicity
LD50 i.v. in mice: 17 mg/kg (Troxler, Seemann, 1977)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B675400
Product name
racBopindolol
Packaging
5mg
Price
$185
Updated
2021/12/16
AK Scientific
Product number
C962
Product name
Bopindolol
Packaging
1mg
Price
$191
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB37307
Product name
Bopindolol
Packaging
5mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB37307
Product name
Bopindolol
Packaging
10mg
Price
$520
Updated
2021/12/16
AK Scientific
Product number
C962
Product name
Bopindolol
Packaging
10mg
Price
$752
Updated
2021/12/16
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Bopindolol Chemical Properties,Usage,Production

Description

Bopindolol is a potent, long-acting, non-selective β-adrenergic blocker related to pindolol and useful in the treatment of hypertension. Unlike many other agents of this type, it appears to have negligible effects on serum lipoproteins.

Chemical Properties

Off-White to pale Yellow Solid

Originator

sandoz (Switzerland)

Uses

Bopindolol is an ester prodrug of Pindolol (P468000). Bopindolol is a long acting β-adrenoceptor blocking agent. Bopindolol displays antispasmogenic activity mediated by α1-adrenoceptors and 5-HT2 receptors.

Definition

ChEBI: 1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate is a methylindole that is 2-methyl-1H-indol-4-ol in which the hydrogen of the hydroxy group is replaced by a 2-(benzoyloxy)-3-(tert-butylamino)propyl group. It is a methylindole, a secondary amino compound, an aromatic ether and a benzoate ester.

Manufacturing Process

4-(2-Benzoyloxy-3-t-butylaminopropoxy)-2-methyl-indole:
26 g of benzoic acid are dissolved, while heating, in 50 ml of hexamethylphosphoric acid triamide and 3.5 g of 1-t-butylamino-3-(2-methylindole- 4-yloxy)-2-propanol are added. After cooling, 3.0 g of benzoic acid anhydride are added and stirred for 20 hours at room temperature. The resulting clear, yellow solution is poured onto ice 0.5 liters of ether are added and stirred for 2 hours. After making the liquid alkaline with concentrated ammonia, the ether phase is separated, shaken out with tartaric acid, made alkaline with caustic soda solution while cooling with ice and extracted with methylene chloride. After evaporating the solvent, the residue is crystallized with 1 mol of fumaric acid from methanol and acetone.

brand name

SANDONORM

Therapeutic Function

Beta-adrenergic blocker

Bopindolol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bopindolol manufacturers

Dideu Industries Group Limited
Product
Bopindolol 62658-63-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-12

62658-63-3, BopindololRelated Search:


  • Bopindolol
  • 2-PROPANOL, 1-[(1,1-DIMETHYLETHYL)AMINO]-3-[(2-METHYL-1H-INDOL-4-YL)OXY]-, BENZOATE (ESTER)
  • 1-(tert-ButylaMino)-3-((2-Methyl-1H-indol-4-yl)oxy)propan-2-yl benzoate
  • 2-[(1,1-Dimethylethyl)amino]-1-{[(2-methyl-1H-indol-4-yl)oxy]methyl}ethyl benzoate
  • (±)-1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol Benzoate (Ester)
  • 1-[(1,1-DiMethylethyl)aMino]-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-propanol 2-Benzoate
  • rac Bopindolol
  • 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, 2-benzoate
  • Bopindolol USP/EP/BP
  • 62658-63-3
  • C23H28N2O3
  • Aromatics
  • Heterocycles
  • Indole Derivatives
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals