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GRAMICIDIN A

Product Name
GRAMICIDIN A
CAS No.
11029-61-1
Chemical Name
GRAMICIDIN A
Synonyms
GA;LGA;GLS2;hLGA;GRAMICIDIN A;GRIMICIDIN A;α-fetoprotein，AFP;GRAMICIDIN A USP/EP/BP;Alpha Foetoprotein,AFP;Alphafoetoprotein, Human
CBNumber
CB5669868
Molecular Formula
C99H140N20O17
Formula Weight
1882.29
MOL File
11029-61-1.mol
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GRAMICIDIN A Property

storage temp. 
2-8°C
solubility 
ethanol: soluble
form 
White to off-white solid
color 
colorless or white
BRN 
6461131
Sequence
{For}-Val-Gly-Ala-{D-Leu}-Ala-{D-Val}-Val-{D-Val}-Trp-{D-Leu}-Trp-{D-Leu}-Trp-{D-Leu}-Trp-{NHCH2CH2OH}
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
MD8230000
Toxicity
mouse,LD50,intraperitoneal,60mg/kg (60mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 240, 1980.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
50845
Product name
Gramicidin A from Bacillus brevis
Purity
≥90% (HPLC)
Packaging
100mg
Price
$1361.6
Updated
2025/07/31
Sigma-Aldrich
Product number
368020
Product name
Gramicidin A, High Purity,
Packaging
25mg
Price
$415
Updated
2025/07/31
Cayman Chemical
Product number
26384
Product name
Gramicidin A
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26384
Product name
Gramicidin A
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
26384
Product name
GramicidinA
Purity
≥90%
Packaging
10mg
Price
$184
Updated
2024/03/01
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GRAMICIDIN A Chemical Properties,Usage,Production

Uses

Gramicidin A is an effective antibiotic against Gram positive organisms.

Biological Activity

Cell permeable: no', 'Primary Target
Causes the formation of a monovalent cation-selective ion channel', 'Product does not compete with ATP.', 'Reversible: no

in vivo

Gramicidin A (0.11 mg/kg; intratumoral injection; twice weekly for 14 days) inhibits the growth of RCC tumor xenografts[2].
Gramicidin A (0.22 mg/kg; intratumoral injection; thrice weekly for 26 days) inhibits the growth and angiogenesis of VHL-expressing RCC tumor xenografts[3].

Animal Model:Female hairless Nu/J mice, 6- to 8-week old, injected subcutaneously with a suspension of SN12C cells (1.0 × 106) in a 50% growth factor–reduced Matrigel solution[2]
Dosage:0.11 mg/kg body weight
Administration:Intratumoral injection, twice weekly for 14 days
Result:The average tumor mass was reduced by approximately 40% without significant toxicity.
Animal Model:Female hairless 6- to 8-week-old Nu/J mice, injected subcutaneously with a suspension of Caki-1-td-Tomato cells (1.5 × 106) in a 50% growth factor-reduced Matrigel solution[3].
Dosage:0.22 mg/kg
Administration:Intratumoral injection, thrice weekly for 26 days
Result:Inhibited tumor growth. HIF-2α and GAPDH protein expression was substantially reduced.

Purification Methods

Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]

GRAMICIDIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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GRAMICIDIN A Suppliers

China 82 Germany 1 India 3 Switzerland 2 United Kingdom 4 United States 12 Global 104
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
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View Lastest Price from GRAMICIDIN A manufacturers

Dideu Industries Group Limited
Product
GRAMICIDIN A 11029-61-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-19

11029-61-1, GRAMICIDIN ARelated Search:

Gramicidin >95%,Gramicidin/CH63857,gramicidin from bacillus brevis,GRAMICIDIN D [DUBOS],GRAMICIDIN D,GRAMICIDIN POLY-L-HISTIDINE GRAMICIDIN A GRAMICIDIN S,Gramicidin S1,Gramicidin S-A,Soviet Gramicidin C,GRAMICIDIN C α-fetoprotein GRAMICIDIN C FROM BACILLUS BREVIS GRAMICIDIN diagnosis latex microsphors combining anti fetoprotein AFP Casset AFP Strip AFP (anti-Alpha Fetoprotein(AFP), for conjugation and detection) Gramicidin S hydrochloride Α-FETOPROTEIN gramicidin A, 7-alanine- [Val1]gramicidin A,Gramicidin A 1-L-Val Gramicidin S3 gramicidin-S-synthetase 2 gramicidin(micro) usp23,

  • OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH
  • OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONHCH2CH2OH
  • GA
  • HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH
  • HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH
  • HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH
  • GRAMICIDIN A
  • GRAMICIDIN A, BACILLUS BREVIS
  • GRIMICIDIN A
  • GRAMICIDIN A FROM BACILLUS BREVIS
  • gramicidinafrombacillusbrevis95+%
  • GrimicidinA(HighPurity),Bacillusbrevis
  • Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem
  • ANTI-GLS2 (C-TERM E513) antibody produced in rabbit
  • GLS2
  • Glutaminase liver isoform, mitochondrial
  • Gramicidin A, High Purity,
  • Alphafoetoprotein, Human
  • GRAMICIDIN A USP/EP/BP
  • α-fetoprotein，AFP
  • Gramicidin A, from Bacillus brevis, ≥90% (HPLC)
  • alpha 1 Fetoprotein Protein
  • Alpha Foetoprotein,AFP
  • Gramicidin A, Antibiotic agent
  • Gramicidin A, High Purity, <i>Bacillus brevis</i>
  • hLGA
  • LGA
  • 11029-61-1
  • C99H140N20O17
  • Antibiotics
  • Antibiotics G-M
  • Antibiotics A to Z
  • BioChemical
  • Interferes with Cell Membrane Permeability (Ionophores)Antibiotics
  • A - KAntibiotics
  • Antibacterial
  • Antibiotics A to
  • Antibiotics G-MAntibiotics
  • Chemical Structure Class
  • Inhibits an EnzymeAntibiotics
  • Mechanism of Action
  • Peptides
  • Spectrum of Activity