ChemicalBook > CAS DataBase List > GRAMICIDIN A

GRAMICIDIN A

Product Name: GRAMICIDIN A
CAS No.: 11029-61-1
Chemical Name: GRAMICIDIN A
Synonyms: GA;LGA;GLS2;hLGA;GRAMICIDIN A;GRIMICIDIN A;α-fetoprotein，AFP;GRAMICIDIN A USP/EP/BP;Alpha Foetoprotein,AFP;Alphafoetoprotein, Human
CBNumber: CB5669868
Molecular Formula: C99H140N20O17
Formula Weight: 1882.29
MOL File: 11029-61-1.mol

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GRAMICIDIN A Property

storage temp.: 2-8°C
solubility: ethanol: soluble
form: White to off-white solid
color: colorless or white
BRN: 6461131
Sequence: {For}-Val-Gly-Ala-{D-Leu}-Ala-{D-Val}-Val-{D-Val}-Trp-{D-Leu}-Trp-{D-Leu}-Trp-{D-Leu}-Trp-{NHCH2CH2OH}

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: MD8230000
Toxicity: mouse,LD50,intraperitoneal,60mg/kg (60mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 240, 1980.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 50845
Product name: Gramicidin A from Bacillus brevis
Purity: ≥90% (HPLC)
Packaging: 100mg
Price: $1361.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 368020
Product name: Gramicidin A, High Purity,
Packaging: 25mg
Price: $415
Updated: 2025/07/31

Cayman Chemical

Product number: 26384
Product name: Gramicidin A
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26384
Product name: Gramicidin A
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 26384
Product name: GramicidinA
Purity: ≥90%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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GRAMICIDIN A Chemical Properties,Usage,Production

Uses

Gramicidin A is an effective antibiotic against Gram positive organisms.

Biological Activity

Cell permeable: no', 'Primary Target
Causes the formation of a monovalent cation-selective ion channel', 'Product does not compete with ATP.', 'Reversible: no

in vivo

Gramicidin A (0.11 mg/kg; intratumoral injection; twice weekly for 14 days) inhibits the growth of RCC tumor xenografts^[2].
Gramicidin A (0.22 mg/kg; intratumoral injection; thrice weekly for 26 days) inhibits the growth and angiogenesis of VHL-expressing RCC tumor xenografts^[3].

Animal Model:	Female hairless Nu/J mice, 6- to 8-week old, injected subcutaneously with a suspension of SN12C cells (1.0 × 10⁶) in a 50% growth factor–reduced Matrigel solution^[2]
Dosage:	0.11 mg/kg body weight
Administration:	Intratumoral injection, twice weekly for 14 days
Result:	The average tumor mass was reduced by approximately 40% without significant toxicity.

Animal Model:	Female hairless 6- to 8-week-old Nu/J mice, injected subcutaneously with a suspension of Caki-1-td-Tomato cells (1.5 × 10⁶) in a 50% growth factor-reduced Matrigel solution^[3].
Dosage:	0.22 mg/kg
Administration:	Intratumoral injection, thrice weekly for 26 days
Result:	Inhibited tumor growth. HIF-2α and GAPDH protein expression was substantially reduced.

Purification Methods

Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.]

GRAMICIDIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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GRAMICIDIN A Suppliers

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View Lastest Price from GRAMICIDIN A manufacturers

Dideu Industries Group Limited

Product: GRAMICIDIN A 11029-61-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-19

11029-61-1, GRAMICIDIN ARelated Search:

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OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONCH2CH2OH

OHC-NH-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-CONHCH2CH2OH

HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-NHCH2CH2OH

HCO-VAL-GLY-ALA-D-LEU-ALA-D-VAL-VAL-D-VAL-TRP-D-LEU-TRP-D-LEU-TRP-D-LEU-TRP-NHCH2CH2OH

HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH

GRAMICIDIN A

GRAMICIDIN A, BACILLUS BREVIS

GRIMICIDIN A

GRAMICIDIN A FROM BACILLUS BREVIS

gramicidinafrombacillusbrevis95+%

GrimicidinA(HighPurity),Bacillusbrevis

Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem

ANTI-GLS2 (C-TERM E513) antibody produced in rabbit

GLS2

Glutaminase liver isoform, mitochondrial

Gramicidin A, High Purity,

Alphafoetoprotein, Human

GRAMICIDIN A USP/EP/BP

α-fetoprotein，AFP

Gramicidin A, from Bacillus brevis, ≥90% (HPLC)

alpha 1 Fetoprotein Protein

Alpha Foetoprotein,AFP

Gramicidin A, Antibiotic agent

Gramicidin A, High Purity, <i>Bacillus brevis</i>

hLGA

LGA

11029-61-1

C99H140N20O17

Antibiotics

Antibiotics G-M

Antibiotics A to Z

BioChemical

Interferes with Cell Membrane Permeability (Ionophores)Antibiotics

A - KAntibiotics

Antibacterial

Antibiotics A to

Antibiotics G-MAntibiotics

Chemical Structure Class

Inhibits an EnzymeAntibiotics

Mechanism of Action

Peptides

Spectrum of Activity