ChemicalBook > CAS DataBase List > Cytochalasin H

Cytochalasin H

Product Name
Cytochalasin H
CAS No.
53760-19-3
Chemical Name
Cytochalasin H
Synonyms
paspalin;Nsc305222;paspalinpi;Aids031241;Paspalin P1;Aids-031241;CYTOCHALASIN H;19-triene-1-one;kodocytochalasin-1;Cytochalasin H(CytH)
CBNumber
CB5672741
Molecular Formula
C30H39NO5
Formula Weight
493.63
MOL File
53760-19-3.mol
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Cytochalasin H Property

Melting point:
252-258 °C
Boiling point:
587°C (rough estimate)
Density 
1.1369 (rough estimate)
refractive index 
1.6310 (estimate)
storage temp. 
2-8°C
solubility 
chloroform: 10 mg/mL, clear, colorless
pka
13.88±0.70(Predicted)
form 
A lyophilisate
color 
Long needles from CHCl3/Et2O
BRN 
1632647
InChIKey
NAEWXXDGBKTIMN-QHDZSFFESA-N
SMILES
[C@H]1(CC2=CC=CC=C2)[C@@]2([H])[C@@]3([C@H](OC(C)=O)C=C[C@@](O)(C)C[C@@H](C)CC=C[C@@]3([H])[C@H](O)C(=C)[C@H]2C)C(=O)N1 |t:17,26|
LogP
4.758 (est)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-63
Safety Statements 
28-36/37-45
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
HA5306000
F 
10
HazardClass 
6.1(a)
PackingGroup 
I
Toxicity
cyt-hmn:lym 50 mg/L IJEBA6 16,430,78
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0889
Product name
Cytochalasin H from Phomopsis sp.
Packaging
5mg
Price
$1090
Updated
2023/01/07
Cayman Chemical
Product number
18434
Product name
Cytochalasin H
Purity
≥95%
Packaging
1mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
18434
Product name
Cytochalasin H
Purity
≥95%
Packaging
5mg
Price
$430
Updated
2024/03/01
TRC
Product number
C998715
Product name
CytochalasinH(>90%)
Packaging
1mg
Price
$110
Updated
2021/12/16
Usbiological
Product number
C9093-50H
Product name
Cytochalasin H
Packaging
1mg
Price
$368
Updated
2021/12/16
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Cytochalasin H Chemical Properties,Usage,Production

Uses

Cytochalasin H is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. In vitro, cytochalasin H exhibits antibacterial, antifungal, nematocidal and antitumour activity.

Safety Profile

Poison by intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

in vivo

Cytochalasin H (2.5 mg/kg; i.p.) can delay the growth of A549 xenograft tumors in Balb/cnu/nu mice[2].

Animal Model:male Balb/cnu/nu mice with A549 xenograft[2]
Dosage:2.5 mg/kg
Administration:intraperitoneal injection; 3 injections/week,for 80 days
Result:Attenuated tumor growth in vivo.

storage

+4°C

Cytochalasin H Preparation Products And Raw materials

Raw materials

Preparation Products

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53760-19-3, Cytochalasin HRelated Search:

NONANAMIDE 3-METHYL-1-PENTEN-3-OL DECANAMIDE 2,3-DIMETHYLCYCLOHEXANOL Formetorex 3-AMINO-2,2-DIMETHYL-1-PROPANOL (R)-(-)-PENTEN-2-OL 2-Nonanamine 2-Pyrrolidinone,4-methyl- (S)-2-Aminooctane (2R,5R)-2,5-HEXANEDIOL 5-PHENYL-1-PENTANOL trans-2-Nonen-1-ol N-TERT-BUTYLACETAMIDE 1,3-DIMETHYLBUTYL ACETATE Cytochalasin H CYTOCHALASIN J,cytochalasin J from phomopsis sp. CYTOCHALASIN B, DIHYDRO

  • PASPALIN P1; KODOCYTOCHALASIN 1; CYTOCHALASIN O; NSC305222; 17-DEOXO-21-ACETYLZYGOSPORIN D
  • (11)cytochalasa-6(12),13,19-trien-1-one,21-(acetyloxy)-7,18-dihydroxy-16,18-di
  • (7s,13e,16s,18s,19e,21r)-methyl-10-phenyl
  • 19-triene-1-one
  • 21-acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(11)cytochalasa-6(12),13,
  • cytochalasinhfromphomopsissp.
  • kodocytochalasin-1
  • paspalin
  • paspalinpi
  • CYTOCHALASIN H
  • cytochalasin H from A phomopsis species
  • Kodocytochalasin 1, Paspalin P1, 17-Deoxo-21-acetylzygosporin D
  • (7S,13E,16S,18R,19E,21R)-21-Acetyloxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-trien-1-one
  • Paspalin P1
  • Acetic acid 16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylene-18-oxo-17-aza-tricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl ester
  • Aids031241
  • Aids-031241
  • Nsc305222
  • 17-Deoxo-21-acetylzygosporin D
  • Cytochalasin H(CytH)
  • 1H-Cycloundec[d]isoindol-1-one, 15-(acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
  • Cytochalasin H USP/EP/BP
  • Cytochalasin H (>90%)
  • (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate
  • Cytochalasin H, 10 mM in DMSO
  • 53760-19-3
  • C30H39NO5
  • Actin Inhibitors and Probes
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