TETRANOR-12(S)-HETE

Product Name: TETRANOR-12(S)-HETE
CAS No.: 121842-79-3
Chemical Name: TETRANOR-12(S)-HETE
Synonyms: TETRANOR-12(S)-HETE;KBOVKDIBOBQLRS-ONCCEEIJSA-N;4,6,10-Hexadecatrienoic acid, 8-hydroxy-, [S-(E,Z,Z)]- (9CI)
CBNumber: CB5673889
Molecular Formula: C16H26O3
Formula Weight: 266.38
MOL File: 121842-79-3.mol

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TETRANOR-12(S)-HETE Property

storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .5 mg/ml

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10007207
Product name: tetranor-12(S)-HETE
Purity: ≥98%
Packaging: 25μg
Price: $162
Updated: 2024/03/01

Cayman Chemical

Product number: 10007207
Product name: tetranor-12(S)-HETE
Purity: ≥98%
Packaging: 50μg
Price: $306
Updated: 2024/03/01

Cayman Chemical

Product number: 10007207
Product name: tetranor-12(S)-HETE
Purity: ≥98%
Packaging: 100μg
Price: $578
Updated: 2024/03/01

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TETRANOR-12(S)-HETE Chemical Properties,Usage,Production

Description

12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound.

Uses

Tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE (HY-124404A) in numerous tissues. 12(S)‐HETE to tetranor‐12(S)‐HETE conversion could be a marker for psoriasis[1].

Definition

ChEBI: Tetranor 12-HETE is a hydroxy fatty acid.

References

[1] Setkowicz M, et al. Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. Br J Dermatol. 2015 Feb;172(2):337-44. DOI:10.1111/bjd.13225

TETRANOR-12(S)-HETE Preparation Products And Raw materials

Raw materials

Preparation Products

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TETRANOR-12(S)-HETE Suppliers

China 14 Switzerland 1 United States 2 Global 17

Shanghai Hongye Biotechnology Co. Ltd

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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MedBioPharmaceutical Technology Inc

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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SHANGHAI ZZBIO CO., LTD.

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Cayman Chemical Company

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Santa Cruz Biotechnology Inc

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Guangzhou Qingyan Biotechnology Co., Ltd.

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Neobioscience Co., Ltd.

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Absin Bioscience Inc.

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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121842-79-3, TETRANOR-12(S)-HETERelated Search:

12(S)-HETE TETRANOR-12(S)-HETE

TETRANOR-12(S)-HETE

KBOVKDIBOBQLRS-ONCCEEIJSA-N

4,6,10-Hexadecatrienoic acid, 8-hydroxy-, [S-(E,Z,Z)]- (9CI)

121842-79-3