ChemicalBook > CAS DataBase List > 12(S)-HETE

12(S)-HETE

Product Name
12(S)-HETE
CAS No.
54397-83-0
Chemical Name
12(S)-HETE
Synonyms
12(S)-HETE;(s)-12-hete;12(S) HETE,12(S)HETE;12(S)-HETE MaxSpecStandard;12(S)-HETE Lipid Maps MS Standard;(S)-12-Hydroxyeicosatetraenoic acid;12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid;12(S)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A;12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
CBNumber
CB0483829
Molecular Formula
C20H32O3
Formula Weight
320.47
MOL File
54397-83-0.mol
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12(S)-HETE Property

Boiling point:
487.7±45.0 °C(Predicted)
Density 
0.984±0.06 g/cm3(Predicted)
Flash point:
14 °C
storage temp. 
-20°C
solubility 
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form 
Liquid.
pka
4.75±0.10(Predicted)
color 
Colorless to light yellow
BRN 
2656104
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
7-16-26-36
RIDADR 
UN 1170 3/PG 2
WGK Germany 
1
8-10-23
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H7768
Product name
12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
Purity
~100?μg/mL in ethanol, ≥95% (HPLC)
Packaging
10μg
Price
$319
Updated
2024/03/01
Cayman Chemical
Product number
34570
Product name
12(S)-HETE
Purity
≥98%
Packaging
25μg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
10007248
Product name
12(S)-HETE MaxSpec? Standard
Purity
≥95%
Packaging
10μg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
34570
Product name
12(S)-HETE
Purity
≥98%
Packaging
50μg
Price
$267
Updated
2024/03/01
Cayman Chemical
Product number
34570
Product name
12(S)-HETE
Purity
≥98%
Packaging
100μg
Price
$392
Updated
2024/03/01
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12(S)-HETE Chemical Properties,Usage,Production

Description

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

12(S)-HETE MaxSpec® standard is a quantitative grade standard of 12(S)-HETE that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 12(S)-HETE MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..

Uses

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

Definition

ChEBI: A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.

Biochem/physiol Actions

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.

12(S)-HETE Preparation Products And Raw materials

Raw materials

Preparation Products

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12(S)-HETE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
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96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
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60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
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Yichang Zhongyitai Trading Co., Ltd.
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0717-6449896 13886658719
Fax
0717-6558598
Email
root@zhongyitai.com
Country
China
ProdList
1977
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Sigma-Aldrich
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021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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Alfa Chemistry
Tel
1-516-6625404
Fax
1-516-927-0118
Email
support@alfa-chemistry.com
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United States
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9171
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58

54397-83-0, 12(S)-HETERelated Search:


  • 12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
  • 12(S)-HETE
  • 12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID
  • 12(S)-HETE Lipid Maps MS Standard
  • [S-(E,Z,Z,Z)]-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • 12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • 12(S)-HETE MaxSpecStandard
  • (12S,5Z,8Z,10E,14Z)-12-Hydroxyeicosatetraenoic acid
  • 12(S)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A
  • 12(S)-HYDROXY-(5Z,8Z,10E,14Z)-*EICOSATET RAENOIC ACI
  • (s)-12-hete
  • (5Z,8Z,10E,12S,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid
  • (5Z,8Z,10E,12S,14Z)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
  • (S)-12-Hydroxyeicosatetraenoic acid
  • 12(S)-HETE;12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
  • 5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,12S,14Z)-
  • 12(S) HETE,12(S)HETE
  • 54397-83-0
  • Biochemicals and Reagents
  • Fatty Acids
  • Unsaturated fatty acids and derivatives
  • Lipids
  • Omega 6 fatty acids and derivatives
  • Polyunsaturated
  • BioChemical
  • Aliphatics
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Metabolites & Impurities