12(S)-HETE
- Product Name
- 12(S)-HETE
- CAS No.
- 54397-83-0
- Chemical Name
- 12(S)-HETE
- Synonyms
- 12(S)-HETE;(s)-12-hete;12(S) HETE,12(S)HETE;12(S)-HETE MaxSpecStandard;12(S)-HETE Lipid Maps MS Standard;(S)-12-Hydroxyeicosatetraenoic acid;12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid;12(S)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A;12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
- CBNumber
- CB0483829
- Molecular Formula
- C20H32O3
- Formula Weight
- 320.47
- MOL File
- 54397-83-0.mol
12(S)-HETE Property
- Boiling point:
- 487.7±45.0 °C(Predicted)
- Density
- 0.984±0.06 g/cm3(Predicted)
- Flash point:
- 14 °C
- storage temp.
- -20°C
- solubility
- 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
- form
- Liquid.
- pka
- 4.75±0.10(Predicted)
- BRN
- 2656104
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 7-16-26-36
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 1
- F
- 8-10-23
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H7768
- Product name
- 12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
- Purity
- ~100?μg/mL in ethanol, ≥95% (HPLC)
- Packaging
- 10μg
- Price
- $319
- Updated
- 2024/03/01
- Product number
- 34570
- Product name
- 12(S)-HETE
- Purity
- ≥98%
- Packaging
- 25μg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 10007248
- Product name
- 12(S)-HETE MaxSpec? Standard
- Purity
- ≥95%
- Packaging
- 10μg
- Price
- $177
- Updated
- 2024/03/01
- Product number
- 34570
- Product name
- 12(S)-HETE
- Purity
- ≥98%
- Packaging
- 50μg
- Price
- $267
- Updated
- 2024/03/01
- Product number
- 34570
- Product name
- 12(S)-HETE
- Purity
- ≥98%
- Packaging
- 100μg
- Price
- $392
- Updated
- 2024/03/01
12(S)-HETE Chemical Properties,Usage,Production
Description
12(S)-
12(S)-HETE MaxSpec® standard is a quantitative grade standard of 12(S)-HETE that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 12(S)-HETE MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
Uses
A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..
Uses
12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.
Definition
ChEBI: A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.
Biochem/physiol Actions
12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.