12(S)-HETE

Product Name: 12(S)-HETE
CAS No.: 54397-83-0
Chemical Name: 12(S)-HETE
Synonyms: 12(S)-HETE;(s)-12-hete;12(S) HETE,12(S)HETE;12(S)-HETE MaxSpecStandard;12(S)-HETE Lipid Maps MS Standard;(S)-12-Hydroxyeicosatetraenoic acid;12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid;12(S)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A;12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID
CBNumber: CB0483829
Molecular Formula: C20H32O3
Formula Weight: 320.47
MOL File: 54397-83-0.mol

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12(S)-HETE Property

Boiling point:: 487.7±45.0 °C(Predicted)
Density: 0.984±0.06 g/cm3(Predicted)
Flash point:: 14 °C
storage temp.: -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form: Liquid.
pka: 4.75±0.10(Predicted)
color: Colorless to light yellow
BRN: 2656104

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36/37/38
Safety Statements: 7-16-26-36
RIDADR: UN 1170 3/PG 2
WGK Germany: 1
F: 8-10-23

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H7768
Product name: 12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
Purity: ~100?μg/mL in ethanol, ≥95% (HPLC)
Packaging: 10μg
Price: $319
Updated: 2024/03/01

Cayman Chemical

Product number: 34570
Product name: 12(S)-HETE
Purity: ≥98%
Packaging: 25μg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 10007248
Product name: 12(S)-HETE MaxSpec? Standard
Purity: ≥95%
Packaging: 10μg
Price: $177
Updated: 2024/03/01

Cayman Chemical

Product number: 34570
Product name: 12(S)-HETE
Purity: ≥98%
Packaging: 50μg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 34570
Product name: 12(S)-HETE
Purity: ≥98%
Packaging: 100μg
Price: $392
Updated: 2024/03/01

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12(S)-HETE Chemical Properties,Usage,Production

Description

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

12(S)-HETE MaxSpec^® standard is a quantitative grade standard of 12(S)-HETE that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 12(S)-HETE MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..

Uses

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

Definition

ChEBI: A HETE having a (12S)-hydroxy group and (5Z)-, (8Z)-, (10E)- and (14Z)-double bonds.

Biochem/physiol Actions

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.

12(S)-HETE Preparation Products And Raw materials

Raw materials

Preparation Products

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12(S)-HETE Suppliers

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54397-83-0, 12(S)-HETERelated Search:

(±)-5-HETE, (±)-(6E,8Z,11Z,14Z)-5-Hydroxyeicosatetraenoic acid solution dendrotoxin K ANTI-12-(S)-HETE TETRANOR 12(R)-HETE TETRANOR-12(R)-HETE 12(S)-HETE LIPID MAPS TETRANOR-12(S)-HETE 12(R)-HETE 12(R)-HETE LIPID MAPS 12(S)-HETE-D8 12(S)-HETE 12(S),20-DIHETE 12(S)-HETE-[5,6,8,9,11,12,14,15-3H(N)]- 12(S)-HPETE [1-14C] 12(S)-HPETE

12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID

12(S)-HETE

12(S)-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID

12(S)-HETE Lipid Maps MS Standard

[S-(E,Z,Z,Z)]-12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

12-L-Hydroxy-5,8,10,14-eicosatetraenoic Acid

12(S)-HETE MaxSpecStandard

(12S,5Z,8Z,10E,14Z)-12-Hydroxyeicosatetraenoic acid

12(S)-hydroxy-(5Z,8Z,10E,14Z)-*eicosatetraenoic A

12(S)-HYDROXY-(5Z,8Z,10E,14Z)-*EICOSATET RAENOIC ACI

(s)-12-hete

(5Z,8Z,10E,12S,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid

(5Z,8Z,10E,12S,14Z)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid

(S)-12-Hydroxyeicosatetraenoic acid

12(S)-HETE;12(S)-HYDROXY-(5Z,8Z,10E,14Z)-EICOSATETRAENOIC ACID

5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,12S,14Z)-

12(S) HETE,12(S)HETE

54397-83-0

Biochemicals and Reagents

Fatty Acids

Unsaturated fatty acids and derivatives

Lipids

Omega 6 fatty acids and derivatives

Polyunsaturated

BioChemical

Aliphatics

Fatty Acid Derivatives & Lipids

Glycerols

Metabolites & Impurities