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Carbobenzoxyhydrazide

Product Name
Carbobenzoxyhydrazide
CAS No.
5331-43-1
Chemical Name
Carbobenzoxyhydrazide
Synonyms
Benzyl hydrazinecarboxylate;BENZYL CARBAZATE;Benzyl carbazate 97%;Phenylmethyl N-aminocarbamate;BzNN;Z-NHNH2;NSC 2287;Z-HYDRAZIDE;Z-HYDRAZINE;Cbz-Hydrazine
CBNumber
CB5679119
Molecular Formula
C8H10N2O2
Formula Weight
166.18
MOL File
5331-43-1.mol
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Carbobenzoxyhydrazide Property

Melting point:
65-68 °C (lit.)
Boiling point:
294.38°C (rough estimate)
Density 
1.2265 (rough estimate)
refractive index 
1.6180 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
form 
Solid
pka
10.56±0.20(Predicted)
color 
Beige
Water Solubility 
Soluble in water (slightly), methanol and DMSO.
BRN 
1952982
InChIKey
RXUBZLMIGSAPEJ-UHFFFAOYSA-N
CAS DataBase Reference
5331-43-1(CAS DataBase Reference)
NIST Chemistry Reference
Hydrazinecarboxylic acid, phenylmethyl ester(5331-43-1)
EPA Substance Registry System
Hydrazinecarboxylic acid, phenylmethyl ester (5331-43-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-36
WGK Germany 
3
RTECS 
MV1724950
TSCA 
Yes
HS Code 
29280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
499781
Product name
Benzyl carbazate
Purity
97%
Packaging
5g
Price
$39.8
Updated
2025/07/31
Sigma-Aldrich
Product number
499781
Product name
Benzyl carbazate
Purity
97%
Packaging
25g
Price
$167
Updated
2025/07/31
TCI Chemical
Product number
C1564
Product name
Benzyl Carbazate
Purity
>98.0%(T)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
C1564
Product name
Benzyl Carbazate
Purity
>98.0%(T)
Packaging
25g
Price
$49
Updated
2025/07/31
TRC
Product number
B233620
Product name
Benzyl carbazate
Packaging
5g
Price
$55
Updated
2021/12/16
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Carbobenzoxyhydrazide Chemical Properties,Usage,Production

Chemical Properties

LIGHT BEIGE SHINY FLAKES

Uses

Benzyl Carbazate has been shown to prevent the occurrence of oligonucleosome-sized DNA fragmentation in the cell-free system.

Uses

Benzyl carbazate is used as a reagent for preparation of benzyloxycarbonyl (Z, Cbz) hydrazides of carboxylic acids, particularly N-protected amino acids. Subsequent hydrogenolysis gives the hydrazide which can be converted to the azide for coupling with a further amino acid residue by the azide method. It is also used in the preparation of simple acyl or sulfonyl hydrazides avoiding diacylation.

Synthesis

501-53-1

5331-43-1

1. General procedure for the synthesis of benzyl hydrazinecarboxylate: In a three-necked reaction flask equipped with temperature control, hydrazine hydrate (2.0 mol), potassium carbonate (2.0 mol), and 50 mL of tetrahydrofuran are added sequentially. After cooling the reaction system to -20°C, benzyl chloroformate (2.0 mol) was slowly added. After completion of the reaction, stirring was continued for 2 h. The potassium carbonate was subsequently removed by filtration and washed with water. The organic phase was concentrated to give the crude product of benzyl hydrazinecarboxylate (95.0% yield, 96.0% purity as determined by high performance gas chromatography (GC)). 2. Purification of the crude product of benzyl hydrazinecarboxylate: In another three-necked reaction flask, add the crude product of benzyl hydrazinecarboxylate (40.0 g, purity 96.0%, determined by high performance gas chromatography (GC)) and 400 mL of dichloromethane. 80 mL of 30% hydrochloric acid was added dropwise to the reaction system and solid precipitation was observed. 150 mL of water was added to dissolve some of the solids. The organic layer was separated and retained. Add 80 mL of ammonia dropwise to the aqueous layer and adjust the pH to alkaline. The aqueous layer was extracted three times with 250 mL of dichloromethane. The organic phases were combined and concentrated to give purified benzyl hydrazinecarboxylate (36.0 g, 99.5% purity, 90.0% yield as determined by high performance gas chromatography (GC)).

References

[1] Patent: CN103819366, 2016, B. Location in patent: Paragraph 0024-0027
[2] Canadian Journal of Chemistry, 2000, vol. 78, # 7, p. 942 - 949
[3] Chemische Berichte, 1959, vol. 92, p. 1478
[4] Chemische Berichte, 1965, vol. 98, p. 797 - 802

Carbobenzoxyhydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

tert-Butyl 4-hydrazinylpiperidine-1-carboxylate
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View Lastest Price from Carbobenzoxyhydrazide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Carbobenzoxyhydrazide 5331-43-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min HPLC
Supply Ability
500kg
Release date
2021-08-18
Hebei Chuanghai Biotechnology Co., Ltd
Product
Carbobenzoxyhydrazide 5331-43-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-29
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Carbobenzoxyhydrazide 5331-43-1
Price
US $99.00-45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-26

5331-43-1, CarbobenzoxyhydrazideRelated Search:

Benzyl chloroformate 4-Nitrobenzyl chloroformate Benzyl formate Benzyl alcohol Benzyl benzoate tert-Butyl carbazate Methyl carbazate Ethyl carbazate 4-METHOXYBENZYL CARBAZATE 1,2-DICARBOBENZYLOXYHYDRAZINE Benzyl PHENYL FORMATE Benzylhydrazine H-PHE-NHNH-Z TFA 1,3,4-OXADIAZOL-2(3H)-ONE, 5-PHENYL- BOC-ASP(OBZL)-TYR(BZL)-NHNH-Z N-ALPHA-CARBOBENZOXYHYDRAZIDE HYDROCHLORIDE (CBZ-HYDRAZIDO)GLYCINE TRIFLUOROACETATE SALT

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  • Carbazic Acid Benzyl Ester Carbobenzoxyhydrazine N-Cbz-hydrazine
  • Benzyloxycarbonyl hydrazide (free base), Benzyl carbazate (free base)
  • Z- Benzyl carbazate
  • Benzyl carbazate, Benzyl hydrazinecarboxylate, [(Benzyloxy)carbonyl]hydrazine
  • Hydrazine forMic acid benzyl ester
  • Benzyl carbazate 97%
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  • Nα-Z-hydrazide99%
  • CARBOBENZOXYHYDRAZIDE
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  • CARBAZIC ACID BENZYL ESTER
  • BENZYL CARBAZATE
  • BENZYLOXYCARBONYL HYDRAZIDE
  • (BENZYLOXYCARBONYL)HYDRAZINE
  • N-CBZ-HYDRAZINE
  • N-ALPHA-Z-HYDRAZIDE
  • N-ALPHA-CARBOBENZOXYHYDRAZIDE
  • Z-HYDRAZIDE
  • Z-HYDRAZINE
  • Z-NHNH2
  • (Benzyloxycarbonyl)hydrazine, Z-hydrazine
  • BenylCarbazate
  • Cbz-Hydrazine98%
  • Benzyl carbazate, 98+%
  • HYDRAZINECARBOXYLIC ACID BENZYL ESTER
  • Benzyloxycarbonyl hydrazide (free base)
  • Z-NHNH2 (free base)
  • BENZYL CARBAZATE CARBOBENZOXYHYDRAZIDE
  • Benzyl hydrazinecarboxylate
  • benzylhydrazinocarboxylate
  • Hydrazinecarboxylicacid,phenylmethylester
  • Benzyl carbazate, Benzyl hydrazinecarboxylate
  • Hydrazine, N-CBZ protected
  • Benzyl Carbazate &gt
  • BzNN
  • benzyl N-aminocarbamate
  • Carbobenzoxyhydrazide,5331-43-1
  • Phenylmethyl hydrazinecarboxylate
  • Cbz-Hydrazine
  • 5331-43-1
  • H2NNHCO2CH2C6H5
  • Others
  • Protecting and Derivatizing Reagents
  • Protection and Derivatization
  • Synthetic Reagents
  • Phosgene Derivatives