5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE
- Product Name
- 5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE
- CAS No.
- 2725-53-3
- Chemical Name
- 5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE
- Synonyms
- 5-TERT-BUTYLSALICYLALDEHYDE;5-t-Butyl-2-hydroxybenzaldehyde;2-Hydroxy-5-tert-butylbenzaldehyde;5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE;5-tert-Butyl-2-hydroxybenzaldehyde 98%;2-Amino-5-(trifluoromethyl)acetophenone;5-tert-Butyl-2-hydroxybenzaldehyde;5-tert-Butyl-2-hydroxybenzaldehyde, >=95%;5-(TERT-BUTYL)-2-HYDROXYBENZENECARBALDEHYDE;Benzaldehyde,5-(1,1-diMethylethyl)-2-hydroxy-
- CBNumber
- CB5679568
- Molecular Formula
- C11H14O2
- Formula Weight
- 178.23
- MOL File
- 2725-53-3.mol
5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE Property
- Melting point:
- 100-103 °C
- Boiling point:
- 251-252 °C/729 mmHg (lit.)
- Density
- 1.039 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.539(lit.)
- Flash point:
- 220 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 8.39±0.18(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C11H14O2/c1-11(2,3)9-4-5-10(13)8(6-9)7-12/h4-7,13H,1-3H3
- InChIKey
- ZVCQQLGWGRTXGC-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(C(C)(C)C)=CC=C1O
Safety
- Safety Statements
- 23-24/25
- WGK Germany
- 3
- HS Code
- 2912490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 477532
- Product name
- 5-tert-Butyl-2-hydroxybenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $116
- Updated
- 2025/07/31
- Product number
- B6598
- Product name
- 5-(tert-Butyl)-2-hydroxybenzaldehyde
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $165
- Updated
- 2025/07/31
- Product number
- B6598
- Product name
- 5-(tert-Butyl)-2-hydroxybenzaldehyde
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $495
- Updated
- 2025/07/31
- Product number
- B693150
- Product name
- 5-tert-Butyl-2-hydroxybenzaldehyde
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 170245
- Product name
- 5-(tert-Butyl)-2-hydroxybenzenecarbaldehyde
- Packaging
- 500mg
- Price
- $83
- Updated
- 2021/12/16
5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE Chemical Properties,Usage,Production
Uses
5-tert-Butyl-2-hydroxybenzaldehyde is a general chemical reactant/reagent used in the synthesis of Vanadium (V) amino phenolato antitumor agents. As well, its used in the synthesis of dibutyltin complexes for their cytotoxic activity.
Synthesis
98-54-4
100-97-0
2725-53-3
Hexamethylenetetramine (4.77 g, 34.0 mmol) and 4-tert-butylphenol (2.55 g, 17.0 mmol) were dissolved in anhydrous trifluoroacetic acid (30 mL) under nitrogen atmosphere. The reaction mixture was heated to 80 °C and refluxed for 24 hours. Upon completion of the reaction, the mixture was slowly poured into 4 M hydrochloric acid solution (100 mL) and stirred for 10 min, followed by extraction with dichloromethane (2 x 100 mL). The organic phases were combined and washed sequentially with 4 M hydrochloric acid solution (2 × 100 mL) and deionized water (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with dichloromethane as eluent to obtain the target product 5-tert-butyl-2-hydroxybenzaldehyde (1.85 g, yield 61.06%) in the form of yellow viscous liquid.
References
[1] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2018, vol. 204, p. 657 - 664
[2] Synthesis, 1998, # 7, p. 1029 - 1032
[3] Monatshefte fuer Chemie, 1950, vol. 81, p. 1098,1106
[4] Journal of the American Chemical Society, 1950, vol. 72, p. 4324
5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE manufacturers
- Product
- 5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE 2725-53-3
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%； 99%
- Supply Ability
- 1kg; 5kg; 10kg；25kg
- Release date
- 2020-01-07