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Formoterol fumarate

Product Name
Formoterol fumarate
CAS No.
43229-80-7
Chemical Name
Formoterol fumarate
Synonyms
Aformoterol;FORMOTEROL HEMIFUMARATE;YM 08316;FarMeterol;CGP 25827A;NSC 299587;CGP-25827A-e;Fumarate dihydrate;FORMAMIDE FUMARATE;FORADIL;FORMOTEROL
CBNumber
CB5689602
Molecular Formula
C42H52N4O12
Formula Weight
804.88
MOL File
43229-80-7.mol
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Formoterol fumarate Property

Melting point:
138-140°C
storage temp. 
Room temperature
solubility 
Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
pka
pKa1 7.9; pKa2 9.2(at 25℃)
form 
Solid
color 
White to off-white
λmax
284nm(lit.)
Merck 
14,4245
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

RIDADR 
3249
RTECS 
LQ2988000
HazardClass 
6.1(b)
PackingGroup 
II
Toxicity
LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H370Causes damage to organs

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000339
Product name
Formoterol for impurity I identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000339
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000340
Product name
Formoterol fumarate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000340
Price
$218
Updated
2023/01/07
Cayman Chemical
Product number
15584
Product name
Formoterol (hemifumarate)
Purity
≥99%
Packaging
10mg
Price
$88
Updated
2021/12/16
Cayman Chemical
Product number
15584
Product name
Formoterol (hemifumarate)
Purity
≥99%
Packaging
50mg
Price
$352
Updated
2021/12/16
Tocris
Product number
1448
Product name
Formoterolhemifumarate
Purity
≥99%(HPLC)
Packaging
10
Price
$162
Updated
2021/12/16
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Formoterol fumarate Chemical Properties,Usage,Production

Description

Formoterol fumarate is a β2-selective adrenergic agonist useful in the treatment of bronchial asthma. It s potency and duration of action a r e reported to exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.

Chemical Properties

Crystalline Solid

Originator

Yarnanouchi (Japan)

Uses

Formoterol fumarate is a potent β2-AR agonist.

Uses

antiasthmatic;?2-agonist

Uses

long-acting β 2-agonist, anti-asthmatic

Uses

A selective 2-adrenergic receptor agonist. Used as an antiasthmatic

Definition

ChEBI: (S,S)-formoterol fumarate is a fumarate salt prepared from (S,S)-formoterol by reaction of one molecule of fumaric acid for every two molecules of (S,S)-formoterol. It contains a (S,S)-formoterol(1+). It is an enantiomer of an arformoterol fumarate.

brand name

Foradil (Novartis);ATOCK.

Mechanism of action

This is believed to result from formoterol's greater water solubility, allowing it to get to the receptor sites faster, whereas its moderate lipophilicity keeps it in the lungs longer. It is indicated for the long-term maintenance treatment of asthma and for patients with symptoms of nocturnal asthma who require regular treatment with inhaled, short-acting, β2-agonists. It is not indicated for patients whose asthma can be managed by occasional use of inhaled, short-acting, β2-agonists. Formoterol is available only as a powder in a capsule for administration via the aerosolizer. Patients should be cautioned not to take the capsules orally and to keep them in a safe place to avoid accidental oral administration.

Clinical Use

Formoterol has a β-directing N-isopropyl-p-methoxyphenyl group and a unique m-formamide and p-hydroxyphenyl ring, which provides selectivity for β2-receptors. It is resistant to MAO and COMT, making it a long-acting agonist. Formoterol has a more rapid onset as compared to salmeterol while maintaining the same long duration of action.

storage

Store at RT

References

1) Anderson et al. (1993), Formoterol: pharmacology, molecular basis of agonism and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator; Life Sciences, 52 2145 2) Teng et al. (2005), Structure-activity relationship study of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett., 15 5039 3) Noguchi et al. (2015), Effect of beta2-adrenergic agonist on eosinophil adhesion, superoxide anion generation, and degranulation; Allergol. Int., 64 S46 4)Busquets et al. (2004), Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting; Cancer Res., 64 6725 5) O’Neill et al. (2020), Pharmacological targeting of ?2-adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson’s disease; Br. J. Pharmacol., 177 282

Formoterol fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

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Formoterol fumarate Suppliers

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View Lastest Price from Formoterol fumarate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Formoterol Fumarate Anhydrous 43229-80-7
Price
US $0.00/g/Bag
Min. Order
10g
Purity
98.5%min; JP14
Supply Ability
20kg/month
Release date
2021-06-03
Hebei Mingeng Biotechnology Co., Ltd
Product
Formoterol Hemifumarate 43229-80-7
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-28
Baoji Guokang Healthchem co.,ltd
Product
Formoterol fumarate 43229-80-7
Price
US $133.00/g/Bag
Min. Order
1g
Purity
99%
Supply Ability
1000KG
Release date
2021-06-04

43229-80-7, Formoterol fumarateRelated Search:

3-Diethylaminophenol Ketotifen fumarate Ferrous fumarate 1-Hydroxyethylidene-1,1-diphosphonic acid Dimethyl fumarate Quetiapine fumarate CHLOROPHOSPHONAZO III Fumaric acid 4-Methoxyphenylacetone (Trifluoromethoxy)benzene 1,5-Diphenylcarbazide Formoterol fumarate dihydrate Formoterol (N,O-DIBENZYLATED) FORMOTEROL FUMARATE, 98% ( FOR FORMOTEROL FUMARATE ),N,O-DIBENZYLATED FORMOTEROL FUMARATE Formamide FUMARATE FORMOTEROL FUMARATE FOR SYSTEM SUITABILITY FORMOTEROL FUMARATE HYDRATE

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  • rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide Fumarate Dihydrate
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  • (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2
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  • ForMoterol FuMarate Dihydrate API
  • N-(2-hydroxy-5-((S)-1-hydroxy-2-((S)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide hemifumaric acid
  • Formoterol fumarate N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate
  • Aformoterol
  • CGP 25827A
  • Eformoterol fumarate
  • Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel-, (2E)-2-butenedioate (2:1) (salt)
  • Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)-, (E)-2-butenedioate (2:1) (salt)
  • Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-, (E)-2-butenedioate (2:1) (salt)
  • NSC 299587
  • YM 08316
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  • FORMOTEROL HEMIFUMARATE
  • n-[2-hydroxy-5-[[(1rs)-1-hydroxy-2-[[(1rs)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (e)-2-butenedioate
  • BD-40A, Atock, Foradil, Oxeze
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  • (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (2:1) salt
  • CGP-25827A-e
  • Fumarate dihydrate
  • FORMAMIDE FUMARATE
  • rel-N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide hemifumarate
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  • Formoterol Fumarate Anhydrous
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  • Sialyllactose Impurity 21
  • N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide, fumarate (2:1)
  • 43229-80-7
  • 13229-80-7