2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
- Product Name
- 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
- CAS No.
- 107873-03-0
- Chemical Name
- 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
- Synonyms
- 2,2-difluorocyclopropane-1-carboxylic acid;2-Carboxy-1,1-difluorocyclopropane;2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID;2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID;2,1-difluoro-Cyclopropanecarboxylic acid;2,2-Difluoro-cyclopropan-carboxylic acid;Cyclopropanecarboxylic acid, 2,2-difluoro-;2,2-Difluorocyclopropanecarboxylic acid 97%;2,2-
Difluorocyclopropanecarboxylic acid;2,2-Difluorocyclopropane-1-carboxylic acid 98% - CBNumber
- CB5692934
- Molecular Formula
- C4H4F2O2
- Formula Weight
- 122.07
- MOL File
- 107873-03-0.mol
2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Property
- Melting point:
- 60-65 °C
- Boiling point:
- 70 °C/7 mmHg
- Density
- 1.48±0.1 g/cm3(Predicted)
- Flash point:
- 70°C/7mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.22±0.22(Predicted)
- form
- crystalline powder
- color
- White
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C4H4F2O2/c5-4(6)1-2(4)3(7)8/h2H,1H2,(H,7,8)
- InChIKey
- KMLMOVWSQPHQME-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)CC1(F)F
- CAS DataBase Reference
- 107873-03-0(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- 3265
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 684678
- Product name
- 2,2-Difluorocyclopropanecarboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $105
- Updated
- 2025/07/31
- Product number
- D5977
- Product name
- 2,2-Difluorocyclopropanecarboxylic Acid
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $88
- Updated
- 2025/07/31
- Product number
- D5977
- Product name
- 2,2-Difluorocyclopropanecarboxylic Acid
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $266
- Updated
- 2025/07/31
- Product number
- D452458
- Product name
- 2,2-Difluorocyclopropanecarboxylic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2221-3-X2
- Product name
- 2,2-Difluorocyclopropanecarboxylic acid
- Packaging
- 250mg
- Price
- $46
- Updated
- 2021/12/16
2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
2,2-Difluorocyclopropanecarboxylic acid derivative (i.e. 2,2-difluorocyclopropanecarbonyl chloride) is used in Friedel-Crafts reactions with various arenes to prepare aryl 2,2-difluorocyclopropyl ketones.
Synthesis
260352-79-2
107873-03-0
The general procedure for the synthesis of 2,2-difluorocyclopropanecarboxylic acid from butyl 2,2-difluorocyclopropanecarboxylate was as follows: butyl 2,2-difluorocyclopropanecarboxylate (65.0 g, 330 mmol) was dissolved in anhydrous aqueous NaOH solution (750 mL of H2O, 52.5 g of NaOH), and the reaction was carried out at reflux for about 14 h, during which a light yellow solution was formed. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under vacuum to about 250 mL. the residue was adjusted to pH 3-4 with concentrated aqueous hydrochloric acid (about 70 mL) in an ice bath (0-5 °C). the resulting solution was extracted with ethyl acetate (2 x 500 mL), and the organic layers were combined and dried over anhydrous sodium sulfate. Finally, the dried organic layer was concentrated under high vacuum to afford 2,2-difluorocyclopropanecarboxylic acid (30 g, 75% yield) as a yellow oil, which gradually solidified to a light yellow solid after standing. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 10.78 (s, 1H), 2.41-2.47 (m, 1H), 2.05-2.08 (m, 1H), 1.80-1.83 (m, 1H).
References
[1] Journal of Fluorine Chemistry, 2005, vol. 126, # 3, p. 339 - 343
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4104 - 4114
[3] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 96-97
[4] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3450 - 3456
2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Suppliers
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 022-23869539 18920052327
- Fax
- 022-83711180
- 281258989@qq.com
- Country
- China
- ProdList
- 63
- Advantage
- 58
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 15556698229
- 314236317@qq.com
- Country
- China
- ProdList
- 225
- Advantage
- 58
- Tel
- 18860950986
- tangmanman@lebangpharma.com
- Country
- China
- ProdList
- 650
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 1005
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +49-(0)2383-919350
- Fax
- +49-(0)2383-919354
- info@selectlab.de
- Country
- Germany
- ProdList
- 394
- Advantage
- 55
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
View Lastest Price from 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID manufacturers
- Product
- 2,2-Difluorocyclopropanecarboxylic acid 107873-03-0
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- 2,2-Difluoro-cyclopropanecarboxylic acid 107873-03-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- Cyclopropanecarboxylicacid,2,2-difluoro- 107873-03-0
- Price
- US $0.10/kg
- Min. Order
- 0.0005kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-15