ChemicalBook > CAS DataBase List > 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID

2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID

Product Name
2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
CAS No.
107873-03-0
Chemical Name
2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
Synonyms
2,2-difluorocyclopropane-1-carboxylic acid;2-Carboxy-1,1-difluorocyclopropane;2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID;2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID;2,1-difluoro-Cyclopropanecarboxylic acid;2,2-Difluoro-cyclopropan-carboxylic acid;Cyclopropanecarboxylic acid, 2,2-difluoro-;2,2-Difluorocyclopropanecarboxylic acid 97%;2,2-Difluorocyclopropanecarboxylic acid;2,2-Difluorocyclopropane-1-carboxylic acid 98%
CBNumber
CB5692934
Molecular Formula
C4H4F2O2
Formula Weight
122.07
MOL File
107873-03-0.mol
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2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Property

Melting point:
60-65 °C
Boiling point:
70 °C/7 mmHg
Density 
1.48±0.1 g/cm3(Predicted)
Flash point:
70°C/7mm
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
3.22±0.22(Predicted)
form 
crystalline powder
color 
White
Water Solubility 
Soluble in water.
InChI
InChI=1S/C4H4F2O2/c5-4(6)1-2(4)3(7)8/h2H,1H2,(H,7,8)
InChIKey
KMLMOVWSQPHQME-UHFFFAOYSA-N
SMILES
C1(C(O)=O)CC1(F)F
CAS DataBase Reference
107873-03-0(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
3265
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
III
HS Code 
2916200090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
684678
Product name
2,2-Difluorocyclopropanecarboxylic acid
Purity
97%
Packaging
250mg
Price
$105
Updated
2025/07/31
TCI Chemical
Product number
D5977
Product name
2,2-Difluorocyclopropanecarboxylic Acid
Purity
min. 98.0 %
Packaging
1G
Price
$88
Updated
2025/07/31
TCI Chemical
Product number
D5977
Product name
2,2-Difluorocyclopropanecarboxylic Acid
Purity
min. 98.0 %
Packaging
5G
Price
$266
Updated
2025/07/31
TRC
Product number
D452458
Product name
2,2-Difluorocyclopropanecarboxylic acid
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
2221-3-X2
Product name
2,2-Difluorocyclopropanecarboxylic acid
Packaging
250mg
Price
$46
Updated
2021/12/16
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2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

2,2-Difluorocyclopropanecarboxylic acid derivative (i.e. 2,2-difluorocyclopropanecarbonyl chloride) is used in Friedel-Crafts reactions with various arenes to prepare aryl 2,2-difluorocyclopropyl ketones.

Synthesis

260352-79-2

107873-03-0

The general procedure for the synthesis of 2,2-difluorocyclopropanecarboxylic acid from butyl 2,2-difluorocyclopropanecarboxylate was as follows: butyl 2,2-difluorocyclopropanecarboxylate (65.0 g, 330 mmol) was dissolved in anhydrous aqueous NaOH solution (750 mL of H2O, 52.5 g of NaOH), and the reaction was carried out at reflux for about 14 h, during which a light yellow solution was formed. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under vacuum to about 250 mL. the residue was adjusted to pH 3-4 with concentrated aqueous hydrochloric acid (about 70 mL) in an ice bath (0-5 °C). the resulting solution was extracted with ethyl acetate (2 x 500 mL), and the organic layers were combined and dried over anhydrous sodium sulfate. Finally, the dried organic layer was concentrated under high vacuum to afford 2,2-difluorocyclopropanecarboxylic acid (30 g, 75% yield) as a yellow oil, which gradually solidified to a light yellow solid after standing. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 10.78 (s, 1H), 2.41-2.47 (m, 1H), 2.05-2.08 (m, 1H), 1.80-1.83 (m, 1H).

References

[1] Journal of Fluorine Chemistry, 2005, vol. 126, # 3, p. 339 - 343
[2] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4104 - 4114
[3] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 96-97
[4] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3450 - 3456

2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID Suppliers

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View Lastest Price from 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2,2-Difluorocyclopropanecarboxylic acid 107873-03-0
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-09-08
Henan Aochuang Chemical Co.,Ltd.
Product
2,2-Difluoro-cyclopropanecarboxylic acid 107873-03-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Cyclopropanecarboxylicacid,2,2-difluoro- 107873-03-0
Price
US $0.10/kg
Min. Order
0.0005kg
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-15

107873-03-0, 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACIDRelated Search:

2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID, TECH. 2,2-DIFLUOROCYCLOPROPYLMETHANOL 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID 2,2-DIFLUORO-1-METHYLCYCLOPROPANE CARBOXYLIC ACID N-BUTYL 2,2-DIFLUOROCYCLOPROPANECARBOXYLATE (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE

  • Cyclopropanecarboxylic acid, 2,2-difluoro- (9CI)
  • 2,2-Difluorocyclopropanecarboxylic acid, GC 97%
  • 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID, 90% TECH
  • 2,2-difluorocyclopropane-1-carboxylic acid
  • 2-Carboxy-1,1-difluorocyclopropane
  • 2,2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
  • Cyclopropanecarboxylic acid, 2,2-difluoro-
  • 2,2-Difluorocyclopropanecarboxylic acid 97%
  • 2,2-Difluorocyclopropane-1-carboxylic acid 98%
  • 2-DIFLUOROCYCLOPROPANECARBOXYLIC ACID
  • 2,1-difluoro-Cyclopropanecarboxylic acid
  • 2,2-<WBR>Difluorocyclopropanecarboxylic acid
  • 2,2-Difluoro-cyclopropan-carboxylic acid
  • 107873-03-0
  • C4H4F2O2
  • Organic Building Blocks
  • Carboxylic Acids
  • Carbonyl Compounds
  • C1 to C5
  • Building Blocks
  • CARBOXYLICACID
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids