Trimethobenzamide

Product Name: Trimethobenzamide
CAS No.: 138-56-7
Chemical Name: Trimethobenzamide
Synonyms: C07178;TRIMETHOBENZAMIDE;Ro 2-9578 free base;Trimethobenzamide USP/EP/BP;n-[(2-dimethylaminoethoxy)benzyl]-3,4,5-trimethoxybenzamide;n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-benzamid;N-(4-[2-(Dimethylamino)ethoxy]benzyl)-3,4,5-trimethoxybenzamide;N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide;4-(2-dimethylaminoethoxy)-n-(3,4,5-trimethoxybenzoyl)benzylamine;N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
CBNumber: CB5700149
Molecular Formula: C21H28N2O5
Formula Weight: 388.46
MOL File: 138-56-7.mol

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Trimethobenzamide Property

storage temp.: 2-8°C
pka: pKa 8.27±0.03(H2O) (Uncertain)
NIST Chemistry Reference: Benzamide, n-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-(138-56-7)

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Safety

Hazardous Substances Data: 138-56-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0146945
Product name: TRIMETHOBENZAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.21
Updated: 2021/12/16

Aaron Chemicals

Product number: AR0018I1
Product name: Benzamide,N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-
Purity: 95%
Packaging: 100mg
Price: $101
Updated: 2021/12/16

Alichem

Product number: 138567
Product name: N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide
Packaging: 250mg
Price: $203.94
Updated: 2021/12/16

Alichem

Product number: 138567
Product name: N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxybenzamide
Packaging: 1g
Price: $388.97
Updated: 2021/12/16

Chemenu

Product number: CM110386
Product name: Trimethobenzamide
Purity: 95%
Packaging: 1g
Price: $464
Updated: 2021/12/16

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Trimethobenzamide Chemical Properties,Usage,Production

Originator

Tigan,Beecham,US,1973

Uses

Antiemetic.

Definition

ChEBI: The amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans.

Manufacturing Process

To 122 grams (1 mol) of p-hydroxybenzaldehyde in 1 liter of chlorobenzene were added 66 grams (1.04 mols) of sodium methoxide (85%) and 108 grams (1 mol) of 2-dimethylaminoethyl chloride. The mixture was stirred and refluxed for 15 hours, then cooled and the precipitated sodium chloride filtered off. The filtrate was concentrated at steam temperature under water vacuum and the residual oil was fractionated in high vacuum, to give 4-(2- dimethylaminoethoxy)benzaldehyde, BP2.2145°C.
Two teaspoons of Raney nickel catalyst were added to a solution of 65.6 grams (0.34 mol) of 4-(2-dimethylaminoethoxy)benzaldehyde in 300 ml of 10% ammoniacal ethanol. The mixture was hydrogenated at 80°C and a pressure of 1,000 psi. The catalyst was filtered off, the volatiles were distilled off and the residual oil was fractionated in high vacuum, to obtain 4-(2- dimethylaminoethoxy)benzylamine, BP0.3120° to 123°C.
To 9.7 grams (0.05 mol) of 4-(2-dimethylaminoethoxy)benzylamine, dissolved in 100 ml of acetonitrile, was added all at once 12 grams (0.051 mol) of 3,4,5-trimethoxybenzoyl chloride, dissolved in 75 ml of acetonitrile. The mixture was stirred and refluxed for 8 hours, and then cooled. The crystalline solid, which had formed, was filtered off, washed with acetonitrile and recrystallized from acetonitrile, to give 4-(2-dimethylaminoethoxy)-N-(3,4,5- trimethoxybenzoyl)benzylamine hydrochloride, MP 185° to 186°C.

brand name

Tigan (King).

Therapeutic Function

Antinauseant

Trimethobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethobenzamide Suppliers

China 45 India 2 Italy 1 Slovakia 1 United Kingdom 1 United States 9 Global 59

Alfa Chemistry

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Amfinecom Inc.

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Waterstone Technology, LLC

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3B Scientific Corporation

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AK Scientific, Inc.

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American Custom Chemicals Corporation

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138-56-7, TrimethobenzamideRelated Search:

Trimethoprim DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Benzyl nicotinate Dibenzylamine 3-Dimethylaminopropylamine Benzyl benzoate Benzyl alcohol Benzyl chloride Benzyl isocyanate Phenoxybenzamine hydrochloride Dimethylcarbamoyl chloride N,N-Dimethyl-1,4-phenylenediamine 4-Fluorobenzylamine Benzyl TRIMETHOBENZAMIDE HYDROCHLORIDE,Trimethobenzamide HCL 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE Itopride Ethoxy

4-(2-dimethylaminoethoxy)-n-(3,4,5-trimethoxybenzoyl)benzylamine

Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-

n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxy-benzamid

N-(4-[2-(Dimethylamino)ethoxy]benzyl)-3,4,5-trimethoxybenzamide

n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-benzamid

n-[(2-dimethylaminoethoxy)benzyl]-3,4,5-trimethoxybenzamide

N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide

TRIMETHOBENZAMIDE

C07178

N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide

Trimethobenzamide USP/EP/BP

Ro 2-9578 free base

138-56-7

C9H1303