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CARVEDILOL-D5

Product Name
CARVEDILOL-D5
CAS No.
929106-58-1
Chemical Name
CARVEDILOL-D5
Synonyms
CARVEDILOL-D5;Carvedilol-d5 N’-?-D-Glucuronide;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5
CBNumber
CB5704859
Molecular Formula
C24H21D5N2O4
Formula Weight
411.51
MOL File
Mol file
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CARVEDILOL-D5 Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
form 
A solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25218
Product name
Carvedilol-d5
Purity
≥99% deuterated forms (d1-d5)
Packaging
500μg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
25218
Product name
Carvedilol-d5
Purity
≥99% deuterated forms (d1-d5)
Packaging
1mg
Price
$184
Updated
2024/03/01
Usbiological
Product number
005808
Product name
Carvedilol-d5
Packaging
1mg
Price
$460
Updated
2021/12/16
TRC
Product number
C184628
Product name
Carvedilol-d5
Packaging
10mg
Price
$1455
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006704
Product name
CARVEDILOL-D5
Purity
95.00%
Packaging
5MG
Price
$495.59
Updated
2021/12/16
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CARVEDILOL-D5 Chemical Properties,Usage,Production

Description

Carvedilol-d5 is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; Kds = 1.78, 0.4, and 5.01 nM for β1-, β2-, and β3-ARs, respectively). It also binds to α1-, but not α2-, adrenergic receptors (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β1-AR agonist isoproterenol in isolated guinea pig atria (Kb = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (Kb = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α1-AR agonist norepinephrine in isolated rabbit aorta (Kb = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension.

Chemical Properties

White Solid

Uses

Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.

Uses

Labeled Carvedilol, intended for use as an internal standard for the quantification of Carvedilol by GC- or LC-mass spectrometry.

CARVEDILOL-D5 Preparation Products And Raw materials

Raw materials

Preparation Products

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CARVEDILOL-D5 Suppliers

Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
Clearsynth Canada Inc.
Tel
+1.415.685.4395
Fax
+1.415.685.4395
Email
enquiry@clearsynth.com
Country
Canada
ProdList
912
Advantage
58
PI & PI BIOTECH INC.
Tel
020-81716320 17788709170
Fax
020-81716319
Email
Sales@pipitech.com
Country
China
ProdList
2649
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
Hefei Molake Biotechnology Co., Ltd.
Tel
0551-66336380 18956014586
Fax
055166336380
Email
983438788@qq.com
Country
China
ProdList
2123
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Manhag Testing Technology Co., Ltd
Tel
020-020-3846236 17688849268
Email
2443244976@qq.com
Country
China
ProdList
7775
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
0755-66853366; 13670046396
Email
ORDERS@QCSRM.COM
Country
China
ProdList
24326
Advantage
58

929106-58-1, CARVEDILOL-D5Related Search:


  • CARVEDILOL-D5
  • 1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
  • Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5
  • Carvedilol-d5 N’-?-D-Glucuronide
  • 929106-58-1
  • C24H21D5N2O4
  • Isotope