CARVEDILOL-D5
- Product Name
- CARVEDILOL-D5
- CAS No.
- 929106-58-1
- Chemical Name
- CARVEDILOL-D5
- Synonyms
- CARVEDILOL-D5;Carvedilol-d5 N’-?-D-Glucuronide;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is Carvedilol-D5 Q: What is the CAS Number of Carvedilol-D5 Q: What is the storage condition of Carvedilol-D5 Q: What are the applications of Carvedilol-D5
- CBNumber
- CB5704859
- Molecular Formula
- C24H21D5N2O4
- Formula Weight
- 411.51
- MOL File
- Mol file
CARVEDILOL-D5 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
- form
- A solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H401Toxic to aquatic life
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25218
- Product name
- Carvedilol-d5
- Purity
- ≥99% deuterated forms (d1-d5)
- Packaging
- 500μg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 25218
- Product name
- Carvedilol-d5
- Purity
- ≥99% deuterated forms (d1-d5)
- Packaging
- 1mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 005808
- Product name
- Carvedilol-d5
- Packaging
- 1mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- C184628
- Product name
- Carvedilol-d5
- Packaging
- 10mg
- Price
- $1455
- Updated
- 2021/12/16
- Product number
- RDL0006704
- Product name
- CARVEDILOL-D5
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.59
- Updated
- 2021/12/16
CARVEDILOL-D5 Chemical Properties,Usage,Production
Description
Carvedilol-d5 is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; Kds = 1.78, 0.4, and 5.01 nM for β1-, β2-, and β3-ARs, respectively). It also binds to α1-, but not α2-, adrenergic receptors (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β1-AR agonist isoproterenol in isolated guinea pig atria (Kb = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (Kb = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α1-AR agonist norepinephrine in isolated rabbit aorta (Kb = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension.
Chemical Properties
White Solid
Uses
Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.
Uses
Labeled Carvedilol, intended for use as an internal standard for the quantification of Carvedilol by GC- or LC-mass spectrometry.
CARVEDILOL-D5 Preparation Products And Raw materials
Raw materials
Preparation Products
CARVEDILOL-D5 Suppliers
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