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METHYL 2,6-DICHLOROISONICOTINATE

Product Name
METHYL 2,6-DICHLOROISONICOTINATE
CAS No.
42521-09-5
Chemical Name
METHYL 2,6-DICHLOROISONICOTINATE
Synonyms
Methyl 2,6-dichloroi;METHYL 2,6-DICHLOROISONICOTINATE;6-dichloropyridine-4-carboxylate;Methyl 2,6-dichloroisonicotinoate;methyl 2,6-dichloropyridine-4-carboxylate;Methyl 2,6-dichloro-4-pyridinecarboxylate;2,6-Dichloro-isonicotinic acid methyl ester;Methyl 2,6-dichloro-isopyridin-3-carboxylate;Methyl 2,6-dichloropyridine-4-carboxylate 97%;METHYL 2,6-DICHLORO-4-PYRIDINE-CARBOXYLIC ACID
CBNumber
CB5708903
Molecular Formula
C7H5Cl2NO2
Formula Weight
206.03
MOL File
42521-09-5.mol
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METHYL 2,6-DICHLOROISONICOTINATE Property

Melting point:
82 °C
Boiling point:
298℃
Density 
1.426
Flash point:
134℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Sparingly Soluble (0.13 g/L) (25°C)
pka
-4.32±0.10(Predicted)
form 
powder
color 
White
InChI
InChI=1S/C7H5Cl2NO2/c1-12-7(11)4-2-5(8)10-6(9)3-4/h2-3H,1H3
InChIKey
XSKGHSUHOYEBTK-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C(OC)=O)=C1
CAS DataBase Reference
42521-09-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
675962
Product name
Methyl 2,6-dichloropyridine-4-carboxylate
Purity
97%
Packaging
5g
Price
$407
Updated
2023/06/20
TRC
Product number
M301355
Product name
Methyl 2,6-dichloropyridine-4-carboxylate
Packaging
25g
Price
$635
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-5-Y1
Product name
Methyl 2,6-dichloroisonicotinate
Packaging
500mg
Price
$20
Updated
2021/12/16
Oakwood
Product number
066859
Product name
Methyl 2,6-dichloroisonicotinate
Packaging
1g
Price
$20
Updated
2021/12/16
Apolloscientific
Product number
OR29807
Product name
Methyl2,6-dichloroisonicotinate
Packaging
1g
Price
$25
Updated
2021/12/16
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METHYL 2,6-DICHLOROISONICOTINATE Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediates.

Synthesis

5398-44-7

42521-09-5

Step I. Preparation of methyl 2,6-dichloroisonicotinate A mixed solution of 187 g (0.974 mol) of 2,6-dichloroisonicotinic acid, 1650 ml of methanol and 5 ml of concentrated sulfuric acid was heated and refluxed for 24 hours. After completion of the reaction, most of the solvent was evaporated under reduced pressure to give the crude product. The crude product was dissolved in 750 ml of dichloromethane and washed sequentially with water and 1N sodium hydroxide solution. The organic layer was separated and dried with anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure to give 174 g (86.7% yield) of methyl 2,6-dichloroisonicotinate with a melting point of 205 °C.

References

[1] Patent: US4474602, 1984, A

METHYL 2,6-DICHLOROISONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2,6-DICHLOROISONICOTINATE Suppliers

Belgium 1 China 132 Germany 3 India 9 Russia 1 Switzerland 3 United Kingdom 7 United States 26 Global 182
Tianjin Hexin Chengsai Science and Technology Development Co., Ltd.
Tel
022-23410962 13752273685
Email
suna@hisyntech.com
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China
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296
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58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
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China
ProdList
2208
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
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61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
Country
China
ProdList
35896
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
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60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
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64
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View Lastest Price from METHYL 2,6-DICHLOROISONICOTINATE manufacturers

Dideu Industries Group Limited
Product
METHYL 2,6-DICHLOROISONICOTINATE 42521-09-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-28
Career Henan Chemical Co
Product
METHYL 2,6-DICHLOROISONICOTINATE 42521-09-5
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200kg
Release date
2019-08-30

42521-09-5, METHYL 2,6-DICHLOROISONICOTINATERelated Search:

Methylhydrogen dichlorosilane Methylcyclohexane 3,5-DICHLOROBENZYL 2,6-DICHLOROISONICOTINATE 4-(CYANOMETHYL)PHENYL 2,6-DICHLOROISONICOTINATE METHYL 2,6-DICHLOROISONICOTINATE 4-(1,2,3-THIADIAZOL-4-YL)PHENYL 2,6-DICHLOROISONICOTINATE tert-Butyl 2,6-dichloroisonicotinate RARECHEM AL BW 1637 Ethyl 2,6-dichloroisonicotinate [3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOL-4-YL]METHYL 2,6-DICHLOROISONICOTINATE 2-(2,4-DICHLOROPHENOXY)ETHYL 2,6-DICHLOROISONICOTINATE 2-ACETYLPHENYL 2,6-DICHLOROISONICOTINATE 3-Amino-2,6-dichloro-isonicotinic acid ethyl ester 2-CHLORO-4-FLUOROPHENYL 2,6-DICHLOROISONICOTINATE (2,6-DICHLORO-4-PYRIDYL)METHYL 2,6-DICHLOROISONICOTINATE

  • METHYL 2,6-DICHLORO-4-PYRIDINE-CARBOXYLIC ACID
  • METHYL 2,6-DICHLOROISONICOTINATE
  • 2,6-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER
  • 4-PYRIDINECARBOXYLIC ACID, 2,6-DICHLORO-, METHYL ESTER
  • 2,6-Dichloro-isonicotinic acid methyl ester
  • 2,6-Dichloro-4-pyridinecarboxylic acid methyl ester
  • 2,6-Dichloropyridine-4-carboxylic acid methyl ester
  • Methyl 2,6-dichloro-4-pyridinecarboxylate
  • 6-dichloropyridine-4-carboxylate
  • methyl 2,6-dichloropyridine-4-carboxylate
  • Methyl 2,6-dichloropyridine-4-carboxylate, 2,6-Dichloro-4-(methoxycarbonyl)pyridine
  • Methyl 2,6-dichloropyridine-4-carboxylate 97%
  • Methyl 2,6-dichloroisonicotinoate
  • METHYL 2,6-DICHLOROISONICOTINATE ISO 9001：2015 REACH
  • Methyl 2,6-dichloroi
  • 4-Pyridinecarboxylic acid, 2,6-dichloro-, methyl ester (9CI, ACI)
  • 2,6-dichloro-4-Pyridinecarboxylic acid methyl ester (9CI ACI)
  • 4-Pyridinecarboxylicacid, 2,6-dichloro-, methyl est..
  • Methyl 2,6-dichloro-isopyridin-3-carboxylate
  • 42521-09-5
  • Pyridines
  • Halogenated Heterocycles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Esters
  • Pyridines