ChemicalBook > CAS DataBase List > METHYL 2,6-DICHLOROISONICOTINATE

METHYL 2,6-DICHLOROISONICOTINATE

Product Name
METHYL 2,6-DICHLOROISONICOTINATE
CAS No.
42521-09-5
Chemical Name
METHYL 2,6-DICHLOROISONICOTINATE
Synonyms
Methyl 2,6-dichloroi;METHYL 2,6-DICHLOROISONICOTINATE;6-dichloropyridine-4-carboxylate;Methyl 2,6-dichloroisonicotinoate;methyl 2,6-dichloropyridine-4-carboxylate;Methyl 2,6-dichloro-4-pyridinecarboxylate;2,6-Dichloro-isonicotinic acid methyl ester;Methyl 2,6-dichloro-isopyridin-3-carboxylate;Methyl 2,6-dichloropyridine-4-carboxylate 97%;METHYL 2,6-DICHLORO-4-PYRIDINE-CARBOXYLIC ACID
CBNumber
CB5708903
Molecular Formula
C7H5Cl2NO2
Formula Weight
206.03
MOL File
42521-09-5.mol
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METHYL 2,6-DICHLOROISONICOTINATE Property

Melting point:
82 °C
Boiling point:
298℃
Density 
1.426
Flash point:
134℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Sparingly Soluble (0.13 g/L) (25°C)
pka
-4.32±0.10(Predicted)
form 
powder
color 
White
InChI
InChI=1S/C7H5Cl2NO2/c1-12-7(11)4-2-5(8)10-6(9)3-4/h2-3H,1H3
InChIKey
XSKGHSUHOYEBTK-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C(OC)=O)=C1
CAS DataBase Reference
42521-09-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
675962
Product name
Methyl 2,6-dichloropyridine-4-carboxylate
Purity
97%
Packaging
5g
Price
$407
Updated
2023/06/20
TRC
Product number
M301355
Product name
Methyl 2,6-dichloropyridine-4-carboxylate
Packaging
25g
Price
$635
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-5-Y1
Product name
Methyl 2,6-dichloroisonicotinate
Packaging
500mg
Price
$20
Updated
2021/12/16
Oakwood
Product number
066859
Product name
Methyl 2,6-dichloroisonicotinate
Packaging
1g
Price
$20
Updated
2021/12/16
Apolloscientific
Product number
OR29807
Product name
Methyl2,6-dichloroisonicotinate
Packaging
1g
Price
$25
Updated
2021/12/16
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METHYL 2,6-DICHLOROISONICOTINATE Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediates.

Synthesis

5398-44-7

42521-09-5

Step I. Preparation of methyl 2,6-dichloroisonicotinate A mixed solution of 187 g (0.974 mol) of 2,6-dichloroisonicotinic acid, 1650 ml of methanol and 5 ml of concentrated sulfuric acid was heated and refluxed for 24 hours. After completion of the reaction, most of the solvent was evaporated under reduced pressure to give the crude product. The crude product was dissolved in 750 ml of dichloromethane and washed sequentially with water and 1N sodium hydroxide solution. The organic layer was separated and dried with anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure to give 174 g (86.7% yield) of methyl 2,6-dichloroisonicotinate with a melting point of 205 °C.

References

[1] Patent: US4474602, 1984, A

METHYL 2,6-DICHLOROISONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 2,6-DICHLOROISONICOTINATE manufacturers

Dideu Industries Group Limited
Product
METHYL 2,6-DICHLOROISONICOTINATE 42521-09-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-28
Career Henan Chemical Co
Product
METHYL 2,6-DICHLOROISONICOTINATE 42521-09-5
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200kg
Release date
2019-08-30

42521-09-5, METHYL 2,6-DICHLOROISONICOTINATERelated Search:

Methylhydrogen dichlorosilane Methylcyclohexane 3,5-DICHLOROBENZYL 2,6-DICHLOROISONICOTINATE 4-(CYANOMETHYL)PHENYL 2,6-DICHLOROISONICOTINATE METHYL 2,6-DICHLOROISONICOTINATE 4-(1,2,3-THIADIAZOL-4-YL)PHENYL 2,6-DICHLOROISONICOTINATE tert-Butyl 2,6-dichloroisonicotinate RARECHEM AL BW 1637 Ethyl 2,6-dichloroisonicotinate [3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOL-4-YL]METHYL 2,6-DICHLOROISONICOTINATE 2-(2,4-DICHLOROPHENOXY)ETHYL 2,6-DICHLOROISONICOTINATE 2-ACETYLPHENYL 2,6-DICHLOROISONICOTINATE 3-Amino-2,6-dichloro-isonicotinic acid ethyl ester 2-CHLORO-4-FLUOROPHENYL 2,6-DICHLOROISONICOTINATE (2,6-DICHLORO-4-PYRIDYL)METHYL 2,6-DICHLOROISONICOTINATE

  • METHYL 2,6-DICHLORO-4-PYRIDINE-CARBOXYLIC ACID
  • METHYL 2,6-DICHLOROISONICOTINATE
  • 2,6-CHLORO-4-PYRIDINECARBOXYLIC ACID METHYL ESTER
  • 4-PYRIDINECARBOXYLIC ACID, 2,6-DICHLORO-, METHYL ESTER
  • 2,6-Dichloro-isonicotinic acid methyl ester
  • 2,6-Dichloro-4-pyridinecarboxylic acid methyl ester
  • 2,6-Dichloropyridine-4-carboxylic acid methyl ester
  • Methyl 2,6-dichloro-4-pyridinecarboxylate
  • 6-dichloropyridine-4-carboxylate
  • methyl 2,6-dichloropyridine-4-carboxylate
  • Methyl 2,6-dichloropyridine-4-carboxylate, 2,6-Dichloro-4-(methoxycarbonyl)pyridine
  • Methyl 2,6-dichloropyridine-4-carboxylate 97%
  • Methyl 2,6-dichloroisonicotinoate
  • METHYL 2,6-DICHLOROISONICOTINATE ISO 9001：2015 REACH
  • Methyl 2,6-dichloroi
  • 4-Pyridinecarboxylic acid, 2,6-dichloro-, methyl ester (9CI, ACI)
  • 2,6-dichloro-4-Pyridinecarboxylic acid methyl ester (9CI ACI)
  • 4-Pyridinecarboxylicacid, 2,6-dichloro-, methyl est..
  • Methyl 2,6-dichloro-isopyridin-3-carboxylate
  • 42521-09-5
  • Pyridines
  • Halogenated Heterocycles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Esters
  • Pyridines