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NO-LOSARTAN A

Product Name
NO-LOSARTAN A
CAS No.
791122-48-0
Chemical Name
NO-LOSARTAN A
Synonyms
NO-LOSARTAN A;NOLosartan A,NO Losartan A;MWJCPZGVGOVWQZ-UHFFFAOYSA-N;[2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOL-5-YL] METHYL ESTER 3-[(NITROOXY)METHYL]-BENZOIC ACID;Benzoic acid, 3-[(nitrooxy)methyl]-, [2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl]methyl ester
CBNumber
CB5714504
Molecular Formula
C30H28ClN7O5
Formula Weight
602.04
MOL File
791122-48-0.mol
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NO-LOSARTAN A Property

Boiling point:
818.4±75.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:5): .5 mg/ml
form 
A crystalline solid
pka
4.16±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10006456
Product name
NO-Losartan A
Purity
≥97%
Packaging
1mg
Price
$19
Updated
2024/03/01
Cayman Chemical
Product number
10006456
Product name
NO-Losartan A
Purity
≥97%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
10006456
Product name
NO-Losartan A
Purity
≥97%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
10006456
Product name
NO-Losartan A
Purity
≥97%
Packaging
50mg
Price
$595
Updated
2024/03/01
AK Scientific
Product number
1947AH
Product name
NO-LosartanA
Packaging
5mg
Price
$185
Updated
2021/12/16
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NO-LOSARTAN A Chemical Properties,Usage,Production

Description

Angiotensin II is a hormone that plays an important role in regulating blood pressure.1 Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.2 Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM.3 In humans, losartan effectively controls hypertension while protecting renal function.4 Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.5,6 NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.7

References

1. Ortiz, M.C., Sanabria, E., Manriquez, M.C., et al. Role of endothelin and isoprostanes in slow pressor responses to angiotensin II Hypertension 37(2),505-511(2001).
2. Schiffrin, E.L. Beyond blood pressure: The endothelium and atherosclerosis progression Am. J. Hypertens. 15(10 Pt 2),115S-122S(2002).
3. Ji, H., Leung, M., Zhang, Y., et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan J. Biol. Chem. 269(24),16533-16536(1994).
4. Caruso, D., D'Avino, M., Acampora, C., et al. Effects of losartan and chlorthalidone on blood pressure and renal vascular resistance index in non-diabetic patients with essential hypertension and normal renal functions J. Cardiovasc. Pharmacol. 44(5),520-524(2004).
5. Moncada, S., and Higgs, A. The L-arginine-nitric oxide pathway N. Engl. J. Med. 329,2002-2012(1993).
6. Loscalzo, J., and Welch, G. Nitric oxide and its role in the cardiovascular system Prog. Cardiovasc. Dis. 38,87-103(1995).
7. Breschi, M.C., Calderone, V., Digiacomo, M., et al. NO-sartans: A new class of pharmacodynamic hybrids as cardiovascular drugs J. Med. Chem. 47,5597-5600(2004).

NO-LOSARTAN A Preparation Products And Raw materials

Raw materials

Preparation Products

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NO-LOSARTAN A Suppliers

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791122-48-0, NO-LOSARTAN ARelated Search:

Losartan Carboxaldehyde O-Acetyl Losartan Losartan potassium Losartan potassium Losartan Impurity 7 Losartan N2-Glucuronide Losartan-d3 Carboxylic Acid LOSARTAN-D4 N-Trityl Losartan Isomer Trityl losartan Losartan Methyl Ether N,O-Ditrityl Losartan N-Trityl Losartan IsoMer Losartan potassium (50 MG) (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL Losartan (5-CHLORO-2-ETHYL-1H-IMIDAZOL-4-YL)-METHANOL NO-LOSARTAN A

  • [2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOL-5-YL] METHYL ESTER 3-[(NITROOXY)METHYL]-BENZOIC ACID
  • NO-LOSARTAN A
  • MWJCPZGVGOVWQZ-UHFFFAOYSA-N
  • NOLosartan A,NO Losartan A
  • Benzoic acid, 3-[(nitrooxy)methyl]-, [2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl]methyl ester
  • 791122-48-0