ChemicalBook > CAS DataBase List > 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE

2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE

Product Name
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
CAS No.
221289-88-9
Chemical Name
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
Synonyms
2-oxo-1,3-dihydrobenzimidazole-5-carbonitrile;2-oxo-2,3-dihydrobenzimidazole-5-carbonitirle ?;2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE;2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile;1H-BenziMidazole-5-carbonitrile, 2,3-dihydro-2-oxo-;2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carbonitrile;1H-Benzimidazole-5-carbonitrile,2,3-dihydro-2-oxo-(9CI);2-oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile(SALTDATA: FREE)
CBNumber
CB5719761
Molecular Formula
C8H5N3O
Formula Weight
159.14
MOL File
221289-88-9.mol
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2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Property

Boiling point:
189.3±19.0 °C(Predicted)
Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
10.98±0.30(Predicted)
Appearance
Light brown to gray Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

AK Scientific
Product number
1219AB
Product name
2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile
Packaging
100mg
Price
$112
Updated
2021/12/16
Matrix Scientific
Product number
085548
Product name
2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile
Purity
95%
Packaging
1g
Price
$524
Updated
2021/12/16
AK Scientific
Product number
1219AB
Product name
2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile
Packaging
5g
Price
$672
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129321
Product name
2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBONITRILE
Purity
95.00%
Packaging
1G
Price
$939.87
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129321
Product name
2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBONITRILE
Purity
95.00%
Packaging
2.5G
Price
$1391.37
Updated
2021/12/16
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2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

17626-40-3

530-62-1

221289-88-9

At room temperature and under argon protection, 3,4-diaminobenzonitrile (200 mg, 1.5 mmol) was dissolved in THF (10 mL), followed by the addition of N,N'-carbonyl diimidazole (243 mg, 1.5 mmol). The reaction mixture was stirred for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with 40% acetone/hexane as eluent to afford 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile (60 mg, 0.37 mmol, 24% yield) as an off-white solid.1H NMR (400 MHz, DMSO-d6): δ 11.16 (br s, 1H), 11.04 (br s, 1H), 7.39 (dd, J = 8.1, 1.6 Hz, 1H), 7.30 (s, 1H), 7.06 (d, J = 8.2 Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3719 - 3742
[2] Patent: WO2017/117393, 2017, A1. Location in patent: Page/Page column 263
[3] Patent: EP2003132, 2008, A1. Location in patent: Page/Page column 23
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5392 - 5395
[5] Patent: WO2018/81167, 2018, A1. Location in patent: Page/Page column 244

2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Suppliers

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View Lastest Price from 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE 221289-88-9
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-19

221289-88-9, 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILERelated Search:

2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE

  • 1H-Benzimidazole-5-carbonitrile,2,3-dihydro-2-oxo-(9CI)
  • 2-oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile(SALTDATA: FREE)
  • 1H-BenziMidazole-5-carbonitrile, 2,3-dihydro-2-oxo-
  • 2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile
  • 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
  • 2-oxo-1,3-dihydrobenzimidazole-5-carbonitrile
  • 2-oxo-2,3-dihydrobenzimidazole-5-carbonitirle ?
  • 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carbonitrile
  • 221289-88-9
  • BENZIMIDAZOLE