2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
- Product Name
- 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
- CAS No.
- 221289-88-9
- Chemical Name
- 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE
- Synonyms
- 2-oxo-1,3-dihydrobenzimidazole-5-carbonitrile;2-oxo-2,3-dihydrobenzimidazole-5-carbonitirle ?;2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE;2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile;1H-BenziMidazole-5-carbonitrile, 2,3-dihydro-2-oxo-;2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carbonitrile;1H-Benzimidazole-5-carbonitrile,2,3-dihydro-2-oxo-(9CI);2-oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile(SALTDATA: FREE)
- CBNumber
- CB5719761
- Molecular Formula
- C8H5N3O
- Formula Weight
- 159.14
- MOL File
- 221289-88-9.mol
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Property
- Boiling point:
- 189.3±19.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 10.98±0.30(Predicted)
- Appearance
- Light brown to gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- 1219AB
- Product name
- 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile
- Packaging
- 100mg
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 085548
- Product name
- 2-Oxo-2,3-dihydro-1H-benzimidazole-5-carbonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $524
- Updated
- 2021/12/16
- Product number
- 1219AB
- Product name
- 2-Oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile
- Packaging
- 5g
- Price
- $672
- Updated
- 2021/12/16
- Product number
- CHM0129321
- Product name
- 2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $939.87
- Updated
- 2021/12/16
- Product number
- CHM0129321
- Product name
- 2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1391.37
- Updated
- 2021/12/16
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
17626-40-3
530-62-1
221289-88-9
At room temperature and under argon protection, 3,4-diaminobenzonitrile (200 mg, 1.5 mmol) was dissolved in THF (10 mL), followed by the addition of N,N'-carbonyl diimidazole (243 mg, 1.5 mmol). The reaction mixture was stirred for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with 40% acetone/hexane as eluent to afford 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile (60 mg, 0.37 mmol, 24% yield) as an off-white solid.1H NMR (400 MHz, DMSO-d6): δ 11.16 (br s, 1H), 11.04 (br s, 1H), 7.39 (dd, J = 8.1, 1.6 Hz, 1H), 7.30 (s, 1H), 7.06 (d, J = 8.2 Hz, 1H).
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3719 - 3742
[2] Patent: WO2017/117393, 2017, A1. Location in patent: Page/Page column 263
[3] Patent: EP2003132, 2008, A1. Location in patent: Page/Page column 23
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5392 - 5395
[5] Patent: WO2018/81167, 2018, A1. Location in patent: Page/Page column 244
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE manufacturers
- Product
- 2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOLE-5-CARBONITRILE 221289-88-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-19