KANAMYCIN SULFATE

ChemicalBook > CAS DataBase List > KANAMYCIN SULFATE

Product Name: KANAMYCIN SULFATE
CAS No.: 70560-51-9
Chemical Name: KANAMYCIN SULFATE
Synonyms: KAMYCIN;KANAMYCIN A;KANAMYCIN SULFATE;KANAMYCIN SULPHATE;Kanamycins (sulfate);KANAMYCIN MONOSULFATE;KANAMYCIN ACID SULFATE;KANAMYCIN SULFATE SALT;KANAMYCIN MONO SULPHATE;KANAMYCIN SULFATE WHITE
CBNumber: CB5722316
Molecular Formula: C18H38N4O15S
Formula Weight: 582.58
MOL File: 70560-51-9.mol

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KANAMYCIN SULFATE Property

storage temp.: 2-8°C
solubility: H₂O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
form: powder
color: white to off-white
BRN: 3874279
CAS DataBase Reference: 70560-51-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 61
Safety Statements: 22-24/25-53-45-36/37/39
WGK Germany: 3
RTECS: NZ3225030

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 60615
Product name: Kanamycin sulfate
Purity: mixture of Kanamycin A (main component) and Kanamycin B and C
Packaging: 5g
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: 60615
Product name: Kanamycin sulfate
Purity: mixture of Kanamycin A (main component) and Kanamycin B and C
Packaging: 25g
Price: $490
Updated: 2024/03/01

Tocris

Product number: 5505
Product name: Kanamycin sulfate
Packaging: 1G
Price: $45
Updated: 2021/12/16

Usbiological

Product number: K0010
Product name: Kanamycin Sulfate
Packaging: 5g
Price: $106
Updated: 2021/12/16

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KANAMYCIN SULFATE Chemical Properties,Usage,Production

Originator

Kantrex,Bristol,US,1958

Uses

Kanamycin Sulfate is an aminoglycoside-antibiotic with broad antibacterial spectrum.

Manufacturing Process

As described in US Patent 2,931,798, Streptomyces kanamyceticus (K2-J) was first cultured in shake flasks in the following media: (a) 0.75% meat extract, 0.75% peptone, 0.3% NaCl, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol; or (b) 2.0% soybean meal, 0.05% KCl, 0.05% MgSO4 · 7H2O, 0.5% NaCl, 0.2% NaNO3, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol. The initial pH of all media was adjusted to 7.0. After 24 to 48 hours shaking in some cases the pH decreased to about 6.0 to 6.8, but from 72 to 120 hours the pH rose and became 7.5 to 8.6. The production of kanamycin was apparent after 48 hours and, depending on the media; the maximum production was found after 72 to 120 hours.
The yield was highest with starch or dextrin, intermediate and about the same with sucrose, glucose, maltose and lactose and poorest with glycerol. Kanamycin was produced by media containing soybean meal, peanut meal, cottonseed meal, corn steep liquor, peptone, yeast extract or meat extract, with or without sodium nitrate. Commercially available soybean meal was recognized to be one of the best nitrogen sources. The addition of corn steep liquor, peptone, yeast extract or nitrate to the soybean meal promoted the production of kanamycin.
The brownish white kanamycin (5 g) was dissolved in 50 ml of 60% aqueous methanol, insoluble material was removed and to the filtrate 40 ml of 60% aqueous methanol containing 2,000 mg of ammonium sulfate was added, and the precipitated kanamycin sulfate was collected, washed with 50 ml of 80% aqueous methanol, and dried. Thus, 4.5 g of kanamycin sulfate was obtained as a light brownish powder.

Therapeutic Function

Antibacterial

Clinical Use

Kanamycin Sulfate was isolated in 1957 by Umezawaand coworkers from Streptomyces kanamyceticus. Its activityagainst mycobacteria and many intestinal bacteria, aswell as several pathogens that show resistance to other antibiotics,brought a great deal of attention to this antibiotic.As a result, kanamycin was tested and released for medicaluse in a very short time.
The use of kanamycin in the United States usually is restrictedto infections of the intestinal tract (e.g., bacillarydysentery) and to systemic infections arising from Gramnegativebacilli (e.g., Klebsiella, Proteus, Enterobacter, andSerratia spp.) that have developed resistance to other antibiotics.It has also been recommended for preoperative antisepsisof the bowel. It is absorbed poorly from the intestinaltract; consequently, systemic infections must be treated byintramuscular or (for serious infections) intravenous injections.These injections are rather painful, and the concomitantuse of a local anesthetic is indicated. The use ofkanamycin in the treatment of TB has not been widely advocatedsince the discovery that mycobacteria develop resistancevery rapidly. In fact, both clinical experience andexperimental work indicate that kanamycin developscross-resistance in the tubercle bacilli with dihydrostreptomycin,viomycin, and other antitubercular drugs. Like streptomycin,kanamycin may cause decreased or complete lossof hearing. On development of such symptoms, its useshould be stopped immediately.

KANAMYCIN SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from KANAMYCIN SULFATE manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: KANAMYCIN SULFATE 70560-51-9
Price: US $1.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-05-24

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Kanamycin Sulfate 70560-51-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000KG
Release date: 2024-03-27

Nantong Guangyuan Chemicl Co,Ltd

Product: KANAMYCIN SULFATE 70560-51-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-16

70560-51-9, KANAMYCIN SULFATERelated Search:

Ampicillin Florfenicol Indinavir sulfate Amikacin Disulfate Amikacin sulfate salt BERBERINE SULFATE TRIHYDRATE Kanamycin sulfate KANAMYCIN KANAMYCIN SULFATE KANAMYCIN

2-(Aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol sulfate

C18H36-37N4-5O10-11H2SO4

Kanmycin MonosulfateSulfate

kanamycin sulfate mixture of components A

KANAMYCIN SULFATE MIXTURE OF COMPONENTS A,B AND C

KANAMYCIN MONOSULFATE

KANAMYCIN MONOSULFATE SALT

KANAMYCIN MONO SULPHATE

KAMYCIN

KANAMYCIN ACID SULFATE

KANAMYCIN A SULFATE SALT

KANAMYCIN SULFATE SALT

KANAMYCIN SULFATE, STREPTOMYCES KANAMYCETICUS

KANAMYCIN SULFATE WHITE

KANAMYCIN SULPHATE

KANAMYCIN A

kanaMycin sulfate Mixture of coMponents

Kanamycin sulfate, >=750 IU/mg

KANAMYCIN SULFATE

KANAMYCIN SULFATE USP/EP/BP

Kanamycin Sulfate DISCONTINUED, UNDEFINED STRUCTURE, offer alternates K137515 or K137500

KANAMYCIN SULFATE Kanamycin sulfate

KANAMYCIN SULFATE(70560-51-9)

Kanamycins (sulfate)

Kanamycin, sulfate (salt) (9CI)

70560-51-9

2539-94-0

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