ChemicalBook > CAS DataBase List > HOECHST 34580

HOECHST 34580

Product Name
HOECHST 34580
CAS No.
23555-00-2
Chemical Name
HOECHST 34580
Synonyms
ProaMine;HOE 34580;HOECHST 34580;Hoechst 34580 (HOE 34580);2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
CBNumber
CB5729663
Molecular Formula
C27H29N7
Formula Weight
451.57
MOL File
23555-00-2.mol
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HOECHST 34580 Property

Melting point:
>300℃
Boiling point:
733.2±70.0 °C(Predicted)
Density 
1.280±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in dimethyl sulfoxide, water
form 
powder
pka
10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃)
color 
Yellow to green
λmax
392nm
Biological Applications
Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences
Product number
CDX-B0094-M005
Product name
Hoechst 34580
Purity
≥98%(HPLC)
Packaging
5mg
Price
$59
Updated
2021/12/16
ChemScene
Product number
CS-1303
Product name
Hoechst 34580
Purity
99.84%
Packaging
5mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-1303
Product name
Hoechst 34580
Purity
99.84%
Packaging
10mg
Price
$108
Updated
2021/12/16
ApexBio Technology
Product number
A3475
Product name
Hoechst 34580
Packaging
25mg
Price
$112
Updated
2021/12/16
ChemScene
Product number
CS-1303
Product name
Hoechst 34580
Purity
99.84%
Packaging
50mg
Price
$288
Updated
2021/12/16
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HOECHST 34580 Chemical Properties,Usage,Production

Biological Activity

Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye used to stain DNA and cell nuclei. It is also a good candidate for the treatment of Alzheimer's disease by inhibiting the formation of amyloid beta (Aβ) with an IC50 value of 0.86 μM.

in vitro

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. It is a good candidate for treating the Alzheimer's disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose- dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86 ±0.05 μM for Hoechst 34580.

target

TargetValue
Aβ
(Cell-free assay)		 0.86 μM

HOECHST 34580 Preparation Products And Raw materials

Raw materials

Preparation Products

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HOECHST 34580 Suppliers

China 57 United States 10 Global 67
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4553
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8014
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
890
Advantage
55
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58

23555-00-2, HOECHST 34580Related Search:


  • HOECHST 34580
  • HOE 34580
  • ProaMine
  • 2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-
  • Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-
  • Hoechst 34580 (HOE 34580)
  • N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
  • N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
  • 23555-00-2
  • C27H32Cl3N7
  • C27H29N7
  • Benzimidazole