4-BENZYLOXY-2-CHLOROPYRIMIDINE

Product Name: 4-BENZYLOXY-2-CHLOROPYRIMIDINE
CAS No.: 108381-28-8
Chemical Name: 4-BENZYLOXY-2-CHLOROPYRIMIDINE
Synonyms: 4-BENZYLOXY-2-CHLOROPYRIMIDINE;2-chloro-4-phenylmethoxypyrimidine;PyriMidine, 2-chloro-4-(phenylMethoxy)-
CBNumber: CB5732410
Molecular Formula: C11H9ClN2O
Formula Weight: 220.65
MOL File: 108381-28-8.mol

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4-BENZYLOXY-2-CHLOROPYRIMIDINE Property

Boiling point:: 387.0±17.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.06±0.20(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C11H9ClN2O/c12-11-13-7-6-10(14-11)15-8-9-4-2-1-3-5-9/h1-7H,8H2
InChIKey: SNCGVIVLUWJDQN-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(OCC2=CC=CC=C2)=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B701933
Product name: 4-(Benzyloxy)-2-chloropyrimidine
Packaging: 25mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB147829
Product name: 4-Benzyloxy-2-chloropyrimidine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB147829
Product name: 4-Benzyloxy-2-chloropyrimidine
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB147829
Product name: 4-Benzyloxy-2-chloropyrimidine
Packaging: 500mg
Price: $225
Updated: 2021/12/16

Apolloscientific

Product number: OR480782
Product name: 4-(Benzyloxy)-2-chloropyrimidine
Packaging: 1g
Price: $262
Updated: 2021/12/16

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4-BENZYLOXY-2-CHLOROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

3934-20-1

100-51-6

108381-28-8

Step 1. 2.26 g (20.1 mmol, 1 eq.) of potassium tert-butanolate and 4.3 g (40.2 mmol, 2 eq.) of benzyl alcohol were dissolved in 10 mL of THF under dry conditions, and the resulting mixture was heated under reflux conditions for 30 min. Subsequently, the reaction mixture was cooled to 0 °C and 3 g (20.1 mmol, 1 eq.) of 2,4-dichloropyrimidine solution dissolved in 15 mL of N,N-dimethylformamide was added drop-wise under strictly controlled conditions below 0 °C. After the dropwise addition, the reaction was continued to be stirred at 0 °C for 1 h, and then warmed up to room temperature naturally. The reaction mixture was slowly poured into 100 mL of ice water and a white solid 4-benzyloxy-2-chloropyrimidine was precipitated, which was collected by filtration to give 3.3 g of product in 75% yield. The structure of the product was confirmed by LC-MS (LC-MS (m/z) = 222.0 [M + H]+).

References

[1] Organic Letters, 2017, vol. 19, # 7, p. 1854 - 1857
[2] Chemistry - A European Journal, 2017, vol. 23, # 58, p. 14563 - 14575
[3] Patent: WO2011/19405, 2011, A1. Location in patent: Page/Page column 107
[4] Patent: US2011/195980, 2011, A1. Location in patent: Page/Page column 28
[5] Patent: EP1564212, 2005, A1. Location in patent: Page 13

4-BENZYLOXY-2-CHLOROPYRIMIDINE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Benzyl alcohol 2,4-Dichloropyrimidine Tetrahydrofuran Methanol Sodium tert-butoxide

Preparation Products

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4-BENZYLOXY-2-CHLOROPYRIMIDINE Suppliers

China 65 France 2 Germany 1 India 2 United Kingdom 2 United States 7 Global 79

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View Lastest Price from 4-BENZYLOXY-2-CHLOROPYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(benzyloxy)-2-chloropyrimidine 108381-28-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

108381-28-8, 4-BENZYLOXY-2-CHLOROPYRIMIDINERelated Search:

4,5-DIHYDRO-2[6-AMINO-2-BENZTHIAZOLYL]-4-THIAZOLE CARBOXYLIC ACID 2,3,5,6-Tetrahydro-1H-[4,4'']bipyridinyl-4-ol 4-Bromomethyl-1-methylindazole 4-(2-THIENYL)BENZOIC ACID 2-Chloropyrimidine 4-BENZYLOXY-2-CHLORO-PYRIMIDIN-5-OL 4-(BENZYLOXY)-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE 4-BENZYLOXY-5-BROMO-2-CHLOROPYRIMIDINE 4-BENZYLOXY-2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 4-BENZYLOXY-2-CHLOROPYRIMIDINE

4-BENZYLOXY-2-CHLOROPYRIMIDINE

PyriMidine, 2-chloro-4-(phenylMethoxy)-

2-chloro-4-phenylmethoxypyrimidine

108381-28-8