ChemicalBook > CAS DataBase List > 4-BENZYLOXY-2-CHLOROPYRIMIDINE

4-BENZYLOXY-2-CHLOROPYRIMIDINE

Product Name
4-BENZYLOXY-2-CHLOROPYRIMIDINE
CAS No.
108381-28-8
Chemical Name
4-BENZYLOXY-2-CHLOROPYRIMIDINE
Synonyms
4-BENZYLOXY-2-CHLOROPYRIMIDINE;2-chloro-4-phenylmethoxypyrimidine;PyriMidine, 2-chloro-4-(phenylMethoxy)-
CBNumber
CB5732410
Molecular Formula
C11H9ClN2O
Formula Weight
220.65
MOL File
108381-28-8.mol
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4-BENZYLOXY-2-CHLOROPYRIMIDINE Property

Boiling point:
387.0±17.0 °C(Predicted)
Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.06±0.20(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C11H9ClN2O/c12-11-13-7-6-10(14-11)15-8-9-4-2-1-3-5-9/h1-7H,8H2
InChIKey
SNCGVIVLUWJDQN-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(OCC2=CC=CC=C2)=N1
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B701933
Product name
4-(Benzyloxy)-2-chloropyrimidine
Packaging
25mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147829
Product name
4-Benzyloxy-2-chloropyrimidine
Packaging
100mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147829
Product name
4-Benzyloxy-2-chloropyrimidine
Packaging
250mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147829
Product name
4-Benzyloxy-2-chloropyrimidine
Packaging
500mg
Price
$225
Updated
2021/12/16
Apolloscientific
Product number
OR480782
Product name
4-(Benzyloxy)-2-chloropyrimidine
Packaging
1g
Price
$262
Updated
2021/12/16
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4-BENZYLOXY-2-CHLOROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

3934-20-1

100-51-6

108381-28-8

Step 1. 2.26 g (20.1 mmol, 1 eq.) of potassium tert-butanolate and 4.3 g (40.2 mmol, 2 eq.) of benzyl alcohol were dissolved in 10 mL of THF under dry conditions, and the resulting mixture was heated under reflux conditions for 30 min. Subsequently, the reaction mixture was cooled to 0 °C and 3 g (20.1 mmol, 1 eq.) of 2,4-dichloropyrimidine solution dissolved in 15 mL of N,N-dimethylformamide was added drop-wise under strictly controlled conditions below 0 °C. After the dropwise addition, the reaction was continued to be stirred at 0 °C for 1 h, and then warmed up to room temperature naturally. The reaction mixture was slowly poured into 100 mL of ice water and a white solid 4-benzyloxy-2-chloropyrimidine was precipitated, which was collected by filtration to give 3.3 g of product in 75% yield. The structure of the product was confirmed by LC-MS (LC-MS (m/z) = 222.0 [M + H]+).

References

[1] Organic Letters, 2017, vol. 19, # 7, p. 1854 - 1857
[2] Chemistry - A European Journal, 2017, vol. 23, # 58, p. 14563 - 14575
[3] Patent: WO2011/19405, 2011, A1. Location in patent: Page/Page column 107
[4] Patent: US2011/195980, 2011, A1. Location in patent: Page/Page column 28
[5] Patent: EP1564212, 2005, A1. Location in patent: Page 13

4-BENZYLOXY-2-CHLOROPYRIMIDINE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Benzyl alcohol 2,4-Dichloropyrimidine Tetrahydrofuran Methanol Sodium tert-butoxide

Preparation Products

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View Lastest Price from 4-BENZYLOXY-2-CHLOROPYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(benzyloxy)-2-chloropyrimidine 108381-28-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15

108381-28-8, 4-BENZYLOXY-2-CHLOROPYRIMIDINERelated Search:

4,5-DIHYDRO-2[6-AMINO-2-BENZTHIAZOLYL]-4-THIAZOLE CARBOXYLIC ACID 2,3,5,6-Tetrahydro-1H-[4,4'']bipyridinyl-4-ol 4-Bromomethyl-1-methylindazole 4-(2-THIENYL)BENZOIC ACID 2-Chloropyrimidine 4-BENZYLOXY-2-CHLORO-PYRIMIDIN-5-OL 4-(BENZYLOXY)-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE 4-BENZYLOXY-5-BROMO-2-CHLOROPYRIMIDINE 4-BENZYLOXY-2-CHLOROPYRIMIDINE-5-BORONIC ACID PINACOL ESTER 4-BENZYLOXY-2-CHLOROPYRIMIDINE

  • 4-BENZYLOXY-2-CHLOROPYRIMIDINE
  • PyriMidine, 2-chloro-4-(phenylMethoxy)-
  • 2-chloro-4-phenylmethoxypyrimidine
  • 108381-28-8