ChemicalBook > CAS DataBase List > 2-((4-Chlorophenyl)acetyl)benzoic acid

2-((4-Chlorophenyl)acetyl)benzoic acid

Product Name
2-((4-Chlorophenyl)acetyl)benzoic acid
CAS No.
53242-76-5
Chemical Name
2-((4-Chlorophenyl)acetyl)benzoic acid
Synonyms
2-[2-(4-chlor;Einecs 258-444-8;AZELASTINE EP IMP C;Azelastine Impurity C;Azelastine EP IMpurity C;Azelastine HCl EP Impurity C;Chlorophenylacetylbenzoic acid;2-(p-Chlorphenacetyl)-Benzoesaeure;2-(4-CHLOROPHENYLACETO)BENZOIC ACID;2-[(4-Chlorophenyl)acetyl]benzoic A
CBNumber
CB5735002
Molecular Formula
C15H11ClO3
Formula Weight
274.7
MOL File
53242-76-5.mol
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2-((4-Chlorophenyl)acetyl)benzoic acid Property

Melting point:
137-141°C
Boiling point:
456.8±30.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
3.36±0.36(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C15H11ClO3/c16-11-7-5-10(6-8-11)9-14(17)12-3-1-2-4-13(12)15(18)19/h1-8H,9H2,(H,18,19)
InChIKey
BDSINYHJZLINDJ-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC=C1C(CC1=CC=C(Cl)C=C1)=O
CAS DataBase Reference
53242-76-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC151136
Product name
2-(4-Chlorophenyl-acetyl)benzoicacid
Packaging
5G
Price
$40
Updated
2021/12/16
AK Scientific
Product number
J10486
Product name
AzelastineImpurityC
Packaging
100mg
Price
$48
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151136
Product name
2-(4-Chlorophenyl-acetyl)benzoicacid
Packaging
10g
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151136
Product name
2-(4-Chlorophenyl-acetyl)benzoicacid
Packaging
25g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
J10486
Product name
AzelastineImpurityC
Packaging
1g
Price
$145
Updated
2021/12/16
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2-((4-Chlorophenyl)acetyl)benzoic acid Chemical Properties,Usage,Production

Uses

2-[(4-Chlorophenyl)acetyl]benzoic Acid is an impurity of Azelastine (A808250).

Uses

2-[(4-Chlorophenyl)acetyl]benzoic Acid (Azelastine EP Impurity C) is an impurity of Azelastine (A808250).

Synthesis

1878-66-6

85-44-9

53242-76-5

P-chlorobenzene acetic acid, phthalic anhydride and freshly melted sodium acetate were added to the reaction kettle in a certain ratio. The reaction was rapidly heated to about 250 °C and continuously stirred at 240-250 °C for 3 h. The water generated during the reaction was discharged through the tail of the reactor. Subsequently, the reaction mixture was transferred to an open heat-resistant vessel and continued to be heated. After the reaction mixture cooled, cold anhydrous ethanol was added. The mixture was heated until the solid was as dissolved as possible, then cooled and filtered. The filter cake was washed with anhydrous ethanol, filtered again and dried. The dried solid was dissolved in aqueous sodium hydroxide solution and stirred under reflux conditions for 4 hours. After completion of the reaction, the mixture was cooled, diluted with water and acidified with 20% hydrochloric acid to pH 2-3. After stirring and cooling, a solid oily precipitate was formed. The precipitate was filtered and dried to give the crude product. The crude product was evaporated from acetone by dissolving in acetone and filtering out the insoluble material. The residue was recrystallized with ethyl acetate to give the final target product 2-(4-chlorophenylacetyl)benzoic acid. The product had a melting point of 142-144 °C and a yield of 80%.

References

[1] Patent: CN108003005, 2018, A. Location in patent: Paragraph 0010; 0011; 0012

2-((4-Chlorophenyl)acetyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-((4-Chlorophenyl)acetyl)benzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-((4-Chlorophenyl)acetyl)benzoic acid 53242-76-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-(2,3-epoxypropyl)phthalimide 53242-76-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-(2,3-epoxypropyl)phthalimide 53242-76-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

53242-76-5, 2-((4-Chlorophenyl)acetyl)benzoic acidRelated Search:

1,2,4-Trichlorobenzene 4-Aminobenzoic acid Acetylacetone Acetyl coenzyme A sodium salt Azelastine-d4 HCl 4-Acetylbenzoic acid Acetyl chloride N-ACETYL-L-TYROSINE ETHYL ESTER Benzoic acid tributyl acetocitrate Anthranilic acid Azelastine azelastine hydrochloride Azelastine Hydrochloride IMpurity D Azelastine EP Impurity E Benzoyl hydrazine 4-(4-CHLOROBENZYL)-2-(2-(1-METHYLPYRROLIDIN-2-YL)ETHYL)PHTHALAZIN-1(2H)-ONE Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide

  • 2-(4-CHLOROPHENYL-ACETYL)BENZOIC ACID
  • 2-(4-CHLOROPHENYLACETO)BENZOIC ACID
  • 2-[2-(4-Chlorophenyl)acetyl]benzoic acid
  • 2-[(4-CHLOROPHENYL) ACETYL] BENZOIC ACID,98+%
  • 2-(2-(4-CHLOROPHENYL)-2-OXOETHYL)BENZOIC ACID
  • Einecs 258-444-8
  • Azelastine EP IMpurity C
  • 2-[2-(4-chlorophenyl)-acetyl]-benzoic acid (intermediate of azelastine hcl)
  • Azelastine HCl EP Impurity C
  • Chlorophenylacetylbenzoic acid
  • NA###2-((4-Chlorophenyl)acetyl)benzoic acid
  • Benzoic acid,2-[2-(4-chlorophenyl)acetyl]-
  • Azelastine Impurity C
  • 2-[(4-Chlorophenyl)acetyl]benzoic Acid, >=99%
  • 2-[2-(4-chlor
  • 2-[2-(4-chlorophenyl)-1-oxoethyl]benzoic acid
  • 2-(p-Chlorphenacetyl)-Benzoesaeure
  • Azelastine Impurity 5(EP Impurity C)
  • 2-[(4-Chlorophenyl)acetyl]benzoic A
  • Azelastine Impurity 5(Azelastine EP Impurity C)
  • 2-(2-(4-Chlorophenyl)acetyl)benzoicaci
  • Azelastine Hydrochloride Impurity C
  • Azelastine Hydrochloride EP Impurity C
  • AZELASTINE EP IMP C
  • 53242-76-5
  • C15Cl11ClO3
  • Aromatics
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Organic acids
  • (intermediate of azelastine hcl)