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GUANABENZ HYDROCHLORIDE

Product Name
GUANABENZ HYDROCHLORIDE
CAS No.
23113-43-1
Chemical Name
GUANABENZ HYDROCHLORIDE
Synonyms
NE56490;uanabenz HCl;GUANABENZ HYDROCHLORIDE;Guanabenzhydrochloride(Wytensin);Guanabenz hydrochloride, 10 mM in DMSO;1-{[(2,6-Dichlorophenyl)methylidene]amino}guanidine Hydrochloride;2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide hydrochloride;Hydrazinecarboximidamide, 2-(2,6-dichlorobenzylidene)-, hydrochloride;inhibit,Guanabenz hydrochloride,antiparasitic,Inhibitor,Beta Receptor,Guanabenz,Parasite,Adrenergic Receptor,antihypertensive,high blood pressure
CBNumber
CB5738700
Molecular Formula
C8H9Cl3N4
Formula Weight
267.54
MOL File
23113-43-1.mol
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GUANABENZ HYDROCHLORIDE Property

storage temp. 
Store at -20°C
solubility 
≥4.3 mg/mL in H2O; ≥4.37 mg/mL in EtOH; ≥9.25 mg/mL in DMSO
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10851
Product name
Guanabenz (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
10851
Product name
Guanabenz (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
10851
Product name
Guanabenz (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$160
Updated
2024/03/01
TRC
Product number
B419480
Product name
1-{[(2,6-Dichlorophenyl)methylidene]amino}guanidineHydrochloride
Packaging
250mg
Price
$90
Updated
2021/12/16
ApexBio Technology
Product number
C3786
Product name
Guanabenz(hydrochloride)
Packaging
50mg
Price
$95
Updated
2021/12/16
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GUANABENZ HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Guanabenz is an α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects. It also competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).

in vitro

maximum concentrations of guanabenz in plasma (1.2 to 5.2 ng/ml) reached 2 to 5 hours after administration of capsules containing 16 or 32 mg of 14c-labelled guanabenz. guanabenz was 90% bound to human plasma proteins [1]. guanabenz competed for imidazoline i2-binding sites in brown adipose tissue with ki of 97 nm [3].

References

[1] holmes b, brogden r n, heel r c, et al. guanabenz[j]. drugs, 1983, 26(3): 212-229.
[2] aantaa r, marjam ki a, scheinin m. molecular pharmacology of α2-adrenoceptor subtypes[j]. annals of medicine, 1995, 27(4): 439-449.
[3] rmer l, wurster s, savola j m, et al. identification and characterization of the imidazoline i2b-binding sites in the hamster brown adipose tissue as a study model for imidazoline receptors[j]. archives of physiology and biochemistry, 2003, 111(2): 159-166.

GUANABENZ HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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GUANABENZ HYDROCHLORIDE Suppliers

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23113-43-1, GUANABENZ HYDROCHLORIDERelated Search:

GUANABENZ GUANABENZ HYDROCHLORIDE

  • GUANABENZ HYDROCHLORIDE
  • Hydrazinecarboximidamide, 2-(2,6-dichlorobenzylidene)-, hydrochloride
  • 1-{[(2,6-Dichlorophenyl)methylidene]amino}guanidine Hydrochloride
  • Guanabenzhydrochloride(Wytensin)
  • NE56490
  • inhibit,Guanabenz hydrochloride,antiparasitic,Inhibitor,Beta Receptor,Guanabenz,Parasite,Adrenergic Receptor,antihypertensive,high blood pressure
  • 2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide hydrochloride
  • uanabenz HCl
  • Guanabenz hydrochloride, 10 mM in DMSO
  • 23113-43-1
  • C8H8Cl2N4HCl