ChemicalBook > CAS DataBase List > F16

F16

Product Name
F16
CAS No.
36098-33-6
Chemical Name
F16
Synonyms
F16;F16 (F-16;Compound F16);F-16;COMPOUND F16;F16/Cell proliferation inhibitor (F16);4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
CBNumber
CB5739848
Molecular Formula
C16H15IN2
Formula Weight
362.21
MOL File
36098-33-6.mol
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F16 Property

storage temp. 
Store at -20°C
solubility 
≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
form 
Orange solid.
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10022
Product name
F16
Purity
≥98%
Packaging
1mg
Price
$14
Updated
2024/03/01
Cayman Chemical
Product number
10022
Product name
F16
Purity
≥98%
Packaging
5mg
Price
$53
Updated
2024/03/01
Cayman Chemical
Product number
10022
Product name
F16
Purity
≥98%
Packaging
10mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
10022
Product name
F16
Purity
≥98%
Packaging
50mg
Price
$384
Updated
2024/03/01
TRC
Product number
F118805
Product name
F16
Packaging
25mg
Price
$95
Updated
2021/12/16
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F16 Chemical Properties,Usage,Production

Uses

F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines.

Biological Activity

f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2].

References

[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336.

F16 Preparation Products And Raw materials

Raw materials

Preparation Products

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F16 Suppliers

Haoyuan Chemexpress Co., Ltd.
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021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
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7552
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HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
Wuhan Greatwall chemical Co,.LTD
Tel
400-027-6116 18086000087
Fax
QQ: 2680733325
Email
sales@chemgreatwall.com
Country
China
ProdList
1559
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Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
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Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10009
Advantage
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
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Beyond Pharmaceutical Co., Ltd
Tel
+86-0571-81953185; 15381198709 15381198709
Fax
0571-89086206
Email
jasonyao@beyond-pharma.com
Country
China
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Musechem
Tel
+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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4660
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Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58

36098-33-6, F16Related Search:


  • F16
  • 4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
  • 4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE
  • F-16;COMPOUND F16
  • Compound F16)
  • F16 (F-16
  • 3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide
  • F16/Cell proliferation inhibitor (F16)
  • 36098-33-6