F16
- Product Name
- F16
- CAS No.
- 36098-33-6
- Chemical Name
- F16
- Synonyms
- F16;F16 (F-16;Compound F16);F-16;COMPOUND F16;F16, 10 mM in DMSO;F16/Cell proliferation inhibitor (F16);4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
- CBNumber
- CB5739848
- Molecular Formula
- C16H15IN2
- Formula Weight
- 362.21
- MOL File
- 36098-33-6.mol
F16 Property
- storage temp.
- Store at -20°C
- solubility
- ≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
- form
- Orange solid.
- color
- Yellow to orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 10022
- Product name
- F16
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $14
- Updated
- 2024/03/01
- Product number
- 10022
- Product name
- F16
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $53
- Updated
- 2024/03/01
- Product number
- 10022
- Product name
- F16
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 10022
- Product name
- F16
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- F118805
- Product name
- F16
- Packaging
- 25mg
- Price
- $95
- Updated
- 2021/12/16
F16 Chemical Properties,Usage,Production
Uses
F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines.
Biological Activity
f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2].
References
[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336.
F16 Preparation Products And Raw materials
Raw materials
Preparation Products
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