ChemicalBook > CAS DataBase List > 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE

2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE

Product Name
2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE
CAS No.
111841-05-5
Chemical Name
2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE
Synonyms
2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE;2-Bromo-1-(5-chloro-3-methoxy-phenyl)-ethanone;Ethanone, 2-bromo-1-(5-chloro-2-methoxyphenyl)-;2-Bromo-1-(5-chloro-2-methoxyphenyl)ethan-1-one
CBNumber
CB5740914
Molecular Formula
C9H8BrClO2
Formula Weight
263.52
MOL File
111841-05-5.mol
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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Property

Boiling point:
326.3±32.0 °C(Predicted)
Density 
1.549±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
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Safety

HS Code 
2914500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B821108
Product name
2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
B821108
Product name
2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging
100mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140834
Product name
2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging
250mg
Price
$105
Updated
2021/12/16
Apolloscientific
Product number
OR500012
Product name
2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging
250mg
Price
$111
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140834
Product name
2-Bromo-1-(5-chloro-2-methoxyphenyl)ethanone
Packaging
100mg
Price
$53
Updated
2021/12/16
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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Chemical Properties,Usage,Production

Synthesis

6342-64-9

111841-05-5

1. Methylation: 5-chloro-2-hydroxyacetophenone (17.0 g, 100 mmol), potassium carbonate (15.1 g, 109 mmol) and iodomethane (12.5 mL, 200 mmol) are dissolved in DMF in a sealed container and stirred at room temperature overnight. Upon completion of the reaction, the DMF was evaporated under reduced pressure and the residue was partitioned with water and ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated to give the crude product. Purification by silica gel column chromatography (eluent: ethyl acetate/hexane) afforded 1-(5-chloro-2-methoxyphenyl)ethanone (17.1 g, 93% yield). Mass spectra (electrospray ionization): (M + 1)+ m/z 185.1, 187.1. 2. Bromination Reaction: 1-(5-chloro-2-methoxyphenyl)ethanone (8.5 g, 46.2 mmol) was dissolved in chloroform (40 mL) and slowly added to a preheated ethyl acetate slurry (150 mL) of copper(II) bromide (20.6 g, 92.4 mmol). The reaction mixture was heated to reflux and maintained for about 1 to 3 hours. After cooling, it was filtered and the filtrate was concentrated to give the crude product. Purification by silica gel column chromatography (eluent: dichloromethane) afforded 2-bromo-1-(5-chloro-2-methoxyphenyl)ethanone (12.0 g, 99% yield). MS (electrospray ionization): (M + 1)+ m/z 185.1, 187.1.

References

[1] Patent: WO2005/19184, 2005, A1. Location in patent: Page/Page column 74
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 5, p. 1291 - 1295
[3] Patent: WO2005/19184, 2005, A1. Location in patent: Page/Page column 43-44
[4] Chemical Communications, 2014, vol. 50, # 51, p. 6726 - 6728
[5] Patent: WO2016/16370, 2016, A1. Location in patent: Page/Page column 44

2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE Suppliers

China 24 India 1 United Kingdom 1 United States 2 Global 28
Synthonix Inc
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info@synthonix.com
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United States
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6872
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Beta Pharma, Inc.
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sales@betapharma.com
Country
United States
ProdList
6226
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111841-05-5, 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONERelated Search:

4-Bromo-7-chloro-9-methyl-3,4-dihydro-2H-benzo[b]oxepin-5-one 2-BROMO-1-(5-CHLORO-2-METHOXY-4-METHYLPHENYL)ETHANONE 3-BROMO-6-CHLORO-7-METHYLCHROMONE 2-BROMO-1-(3,5-DICHLORO-2-METHOXYPHENYL)ETHANONE 3-BROMO-6,8-DICHLORO-4H-CHROMEN-4-ONE 3-BROMO-6-CHLOROCHROMONE 2-BROMO-1-(5-CHLORO-2-METHOXY-4-METHYL-3-NITRO-PHENYL)ETHANONE 2-BROMO-1-(5-CHLORO-2-METHOXY-3-NITROPHENYL)ETHANONE 6-CHLORO-3,8-DIBROMOCHROMONE 3-BROMO-6,7-DICHLOROCHROMONE 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE

  • 2-BROMO-1-(5-CHLORO-2-METHOXY-PHENYL)-ETHANONE
  • 2-Bromo-1-(5-chloro-2-methoxyphenyl)ethan-1-one
  • Ethanone, 2-bromo-1-(5-chloro-2-methoxyphenyl)-
  • 2-Bromo-1-(5-chloro-3-methoxy-phenyl)-ethanone
  • 111841-05-5
  • 11841-05-5