2-PHTHALIMIDOETHANESULFONYL CHLORIDE

Product Name: 2-PHTHALIMIDOETHANESULFONYL CHLORIDE
CAS No.: 4403-36-5
Chemical Name: 2-PHTHALIMIDOETHANESULFONYL CHLORIDE
Synonyms: AKOS MSC-0752;AKOS BBS-00004578;2-Phthalimidoethanesulfonyl chlorid;2-PHTHALIMIDOETHANESULFONYL CHLORIDE;2-Phthalimidoethanesulfonyl chloride - [P3032];2-(1,3-dioxoisoindolin-2-yl)ethane-1-sulfonyl chloride;2H-Isoindole-2-ethanesulfonyl chloride, 1,3-dihydro-1,3-dioxo-;2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONYL CHLORIDE;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethane-1-sulfonyl chloride;2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-ethanesulfonyl chloride
CBNumber: CB5740934
Molecular Formula: C10H8ClNO4S
Formula Weight: 273.69
MOL File: 4403-36-5.mol

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2-PHTHALIMIDOETHANESULFONYL CHLORIDE Property

Melting point:: 158-163℃
Boiling point:: 416.5±28.0 °C(Predicted)
Density: 1.585±0.06 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-50℃
storage temp.: 2-8°C
pka: -2.47±0.20(Predicted)
form: Slurry
color: Yellow to orange to brown
Water Solubility: Reacts with water.
Sensitive: Moisture Sensitive
Stability:: Hygroscopic, Moisture Sensitive
InChIKey: HCPVYBCAYPMANM-UHFFFAOYSA-N
LogP: 1.12-2.44 at 25℃
CAS DataBase Reference: 4403-36-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 34
Safety Statements: 26-36/37/39-45-60
RIDADR: 3261
WGK Germany: 3
HazardClass: 8
PackingGroup: II
HS Code: 29251900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 739820
Product name: 2-Phthalimidoethanesulfonyl chloride
Purity: 95%
Packaging: 1g
Price: $85.2
Updated: 2023/06/20

TCI Chemical

Product number: P2049
Product name: 2-Phthalimidoethanesulfonyl Chloride
Purity: >98.0%(T)
Packaging: 1g
Price: $76
Updated: 2025/07/31

TCI Chemical

Product number: P2049
Product name: 2-Phthalimidoethanesulfonyl Chloride
Purity: >98.0%(T)
Packaging: 5g
Price: $224
Updated: 2025/07/31

Matrix Scientific

Product number: 024771
Product name: 2-Phthalimidoethanesulfonyl chloride
Purity: 95%
Packaging: 1g
Price: $19
Updated: 2021/12/16

Synthonix

Product number: P3032
Product name: 2-Phthalimidoethanesulfonyl chloride
Purity: 97%
Packaging: 1g
Price: $30
Updated: 2021/12/16

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2-PHTHALIMIDOETHANESULFONYL CHLORIDE Chemical Properties,Usage,Production

Uses

2-(Phthalimido)ethanesulfonyl chloride is an important raw material and intermediate used in pharmaceuticals, agro based and dye stuff fields.

Synthesis

85-44-9

107-35-7

4403-36-5

The general procedure for the synthesis of 2-phenylenedi(meth)iminoethane sulfonyl chloride from phthalic anhydride and taurine is as follows:1. A suspension of taurine (8.0 g, 63.9 mmol) and potassium acetate (6.7 g, 68.3 mmol) was refluxed in acetic acid for 15 min. 2. Phthalic anhydride (10.1 g, 68.4 mmol) was added, and the reaction was continued to be refluxed for 3 h. 3. Upon completion of the reaction, the reaction was cooled to room temperature, the solid product was collected by filtration, washed with cold acetic acid and dried under vacuum at 100 °C to give a white solid.4. The above white solid (14.3 g, 54.7 mmol) was suspended in toluene (50 ml), and phosphorus pentachloride (8.12 g, 39.0 mmol) was added under the protection of nitrogen.5. After the reaction mixture was heated and refluxed for 1 hour The reaction mixture was heated and refluxed for 1 hour, then phosphorus pentachloride (8.12 g, 39.0 mmol) was added again and refluxing was continued for another 2.5 hours.6 Upon completion of the reaction, a brownish solution was poured from a small amount of the solid formed, and the solution was subsequently concentrated under vacuum.7 The concentrated residue was poured into a mixture of ice and water (ice:water=50:50, 100 ml), and the solid product was filtered to collect the solid product.8 Finally, the solid was dried under vacuum at 45°C for 16 hours to obtain a light brown color.9 The reaction was carried out under nitrogen protection. Vacuum dried for 16 hours to give a light brown solid product (6.4 g, 34% yield).

References

[1] Patent: US6313312, 2001, B1
[2] Archiv der Pharmazie, 2007, vol. 340, # 12, p. 656 - 660
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2390 - 2400
[4] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 108 - 122

2-PHTHALIMIDOETHANESULFONYL CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PHTHALIMIDOETHANESULFONYL CHLORIDE Suppliers

Belgium 2 China 112 France 3 Germany 6 India 3 Japan 1 The Netherlands 1 United Kingdom 6 United States 27 Global 161

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View Lastest Price from 2-PHTHALIMIDOETHANESULFONYL CHLORIDE manufacturers

Career Henan Chemical Co

Product: 2-PHTHALIMIDOETHANESULFONYL CHLORIDE 4403-36-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

4403-36-5, 2-PHTHALIMIDOETHANESULFONYL CHLORIDERelated Search:

Ethanesulfonyl chloride Ethanethiol, 2-phthalimido- 2-PHTHALIMIDOETHANESULFONYL CHLORIDE

AKOS BBS-00004578

AKOS MSC-0752

2-PHTHALIMIDOETHANESULFONYL CHLORIDE

2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-ETHANESULFONYL CHLORIDE

2-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)ethane-1-sulfonyl chloride

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-ethanesulfonyl chloride

2H-Isoindole-2-ethanesulfonyl chloride, 1,3-dihydro-1,3-dioxo-

2-Phthalimidoethanesulfonyl chlorid

2-(1,3-dioxoisoindolin-2-yl)ethane-1-sulfonyl chloride

2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethane-1-sulfonyl chloride

2-Phthalimidoethanesulfonyl chloride - [P3032]

4403-36-5

C10H8CINO4S

C10H8ClNO4S

SULFONYL CHLORIDE

Building Blocks

Chemical Synthesis

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds