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Methyl 2-chloro-4-fluorobenzoate

Product Name
Methyl 2-chloro-4-fluorobenzoate
CAS No.
85953-29-3
Chemical Name
Methyl 2-chloro-4-fluorobenzoate
Synonyms
RARECHEM AL BF 0289;methyl 2-chloro-4-fluorob...;METHYL 2-CHLORO-4-FLUOROBENZOATE;Methyl2-chloro-4-fluorobenzoate97%;Methyl 2-chloro-4-fluorobenzoate 97%;METHYL 2-CHLORO-4-FLUOROBENZENECARBOXYLATE;2-CHLORO-4-FLUOROBENZOIC ACID METHYL ESTER;Benzoic acid, 2-chloro-4-fluoro-, Methyl ester
CBNumber
CB5741128
Molecular Formula
C8H6ClFO2
Formula Weight
188.58
MOL File
85953-29-3.mol
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Methyl 2-chloro-4-fluorobenzoate Property

Boiling point:
110 °C
Density 
1.314±0.06 g/cm3(Predicted)
refractive index 
1.5150 to 1.5190
Flash point:
103-105°C/15mm
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow
InChI
InChI=1S/C8H6ClFO2/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4H,1H3
InChIKey
YZDLPZNWBRBZMZ-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=C(F)C=C1Cl
CAS DataBase Reference
85953-29-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36
Safety Statements 
26-36/37/39-37/39
RIDADR 
1993
HazardClass 
IRRITANT
HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3102
Product name
Methyl 2-Chloro-4-fluorobenzoate
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
M3102
Product name
Methyl 2-Chloro-4-fluorobenzoate
Purity
>98.0%(GC)
Packaging
25g
Price
$113
Updated
2025/07/31
TRC
Product number
M295583
Product name
Methyl 2-Chloro-4-fluorobenzoate
Packaging
5g
Price
$75
Updated
2021/12/16
TRC
Product number
M295583
Product name
Methyl 2-Chloro-4-fluorobenzoate
Packaging
500mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
2623-7-24
Product name
Methyl 2-chloro-4-fluorobenzoate
Purity
98%
Packaging
25g
Price
$35
Updated
2021/12/16
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Methyl 2-chloro-4-fluorobenzoate Chemical Properties,Usage,Production

Uses

Methyl 2-chloro-4-fluorobenzoate can form complexes with Cu ions for materials chemistry research.

Synthesis

67-56-1

2252-51-9

85953-29-3

General procedure for the synthesis of methyl 2-chloro-4-fluorobenzoate from methanol and 2-chloro-4-fluorobenzoic acid: 2-chloro-4-fluorobenzoic acid (6.5 g, 37 mmol) was dissolved in methanol (100 mL), chlorotrimethylsilane (14.0 mL, 111 mmol) was added, and the reaction was stirred for 24 hours at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was dissolved in dichloromethane, washed with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate, and the solvent was again removed by rotary evaporator to afford methyl 2-chloro-4-fluorobenzoate as a light yellow oil (7.01 g, 99% yield). The product was confirmed by 1H-NMR (CDCl3, 500 MHz): δ 7.93 (m, 1H), 7.22 (m, 1H), 7.06 (m, 1H), 3.95 (s, 3H) ppm; mass spectrometry (FIA) showed the molecular ion peaks m/z 189.1 (M + H); and the retention time for the HPLC analysis (Method A) was 3.37 min.

References

[1] Patent: WO2004/46120, 2004, A2. Location in patent: Page 175; 176
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 21, p. 9524 - 9535
[3] European Journal of Medicinal Chemistry, 2015, vol. 90, p. 195 - 208
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 3130 - 3141

Methyl 2-chloro-4-fluorobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-chloro-4-fluorobenzoate Suppliers

Americas 1 Belgium 2 China 131 Europe 1 France 3 Germany 5 India 5 Italy 1 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 35 Global 206
Ricci Chimica
Tel
--
Fax
--
Email
sales@riccichimica.com
Country
Italy
ProdList
2146
Advantage
46
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View Lastest Price from Methyl 2-chloro-4-fluorobenzoate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 2-chloro-4-fluorobenzoate 85953-29-3
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
2000tons
Release date
2019-12-25
Honest Joy Holdings Limited
Product
Methyl 2-Chloro-4-fluorobenzoate 85953-29-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99.1%
Supply Ability
100 tons
Release date
2022-01-17
Career Henan Chemical Co
Product
Benzoic acid,2-chloro-4-fluoro-, methyl ester 85953-29-3
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

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