Estrone

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Product Name: Estrone
CAS No.: 53-16-7
Chemical Name: Estrone
Synonyms: Estron;200-164-5;1,3,5(10)-ESTRATRIEN-3-OL-17-ONE;Esterone;Hiestrone;OESTRONE;(8R,9S,13S,14S)-3-hydroxy-13-Methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one;ESTROL;FOLLICULIN;Theelin
CBNumber: CB5741416
Molecular Formula: C18H22O2
Formula Weight: 270.37
MOL File: 53-16-7.mol

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Estrone Property

Melting point:: 258-260 °C(lit.)
alpha: 158 º (c=1, dioxane)
Boiling point:: 353.48°C (rough estimate)
Density: 1.2360
refractive index: 165 ° (C=1, Dioxane)
Flash point:: 9℃
storage temp.: room temp
solubility: Chloroform (Slightly), Dioxane (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Crystalline Powder or Crystals
pka: pKa 10.77±0.02(H2O)(Approximate)
color: White to almost white
Water Solubility: 0.03 g/L
Merck: 3708
BRN: 1915077
InChIKey: DNXHEGUUPJUMQT-CBZIJGRNSA-N
CAS DataBase Reference: 53-16-7(CAS DataBase Reference)
NIST Chemistry Reference: 3-Hydroxyestra-1,3,5(10)-trien-17-one(53-16-7)
EPA Substance Registry System: Estrone (53-16-7)

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Safety

Hazard Codes: T,F
Risk Statements: 45-60-61-64-40-63-39/23/24/25-23/24/25-11
Safety Statements: 53-45-36/37-16
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
RTECS: KG8575000
HS Code: 29335995
Hazardous Substances Data: 53-16-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H362May cause harm to breast-fed children

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E-075
Product name: Estrone solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $133
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP860
Product name: Estrone
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 25MG
Price: $298
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1255001
Product name: Estrone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46573
Product name: Estrone
Purity: VETRANAL
Packaging: 250mg
Price: $48.1
Updated: 2022/05/15

Cayman Chemical

Product number: 10006485
Product name: Estrone
Purity: ≥95%
Packaging: 500mg
Price: $12
Updated: 2024/03/01

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Estrone Chemical Properties,Usage,Production

Description

Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.

Chemical Properties

Estrone is an odorless white crystalline powder.
Estrone is supplied as a crystalline solid. A stock solution may be made by dissolving the estrone in an organic solvent purged with an inert gas. Estrone is soluble in organic solvents such as DMSO and dimethyl formamide (DMF). The solubility of estrone in these solvents is approximately 20 mg/ml.
Estrone is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, estrone should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Estrone has a solubility of approximately 0.15 mg/ml in a1:5 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

Originator

Estrone,Abbott

Uses

Estrone is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Uses

A metabolite of 17β-Estradiol.

Uses

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.
Estrone has been used:
as medium supplement for hormone based degranulation studies of natural killer cells.
as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines.

Definition

ChEBI: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.

Manufacturing Process

1-Vinyl-1,2,3,4-tetrahydronaphthalene-1,6-diol reacts with 2- methylcyclopentane-1,3-dione in the presence of Triton B in tert-butanol gives a good yield of δ1,3,5(10),9(11)-8,14-secoestratetraen-3-ol-14,17-dione, melting point 124°-126°C (from methanol).
δ1,3,5(10),9(11)-8,14-Secoestratetraen-3-ol-14,17-dione under influence of hydrochloric acid in tetrahydrofurane cyclises into δ1,3,5(10),8,14-estrapentaen- 3-ol-17-one, melting point 216°-218°C.
δ1,3,5(10),8,14-Estrapentaen-3-ol-17-one is converted to d,l-8-dehydroestrone by selective hydrogenation with hydrogen, melting point 251°-254°C (from methanol). Exhaustive hydrogenation of δ1,3,5(10),8,14-estrapentaen-3-ol-17- one give d,l-8-isoestrone.
d,l-8-Isoestrone in the presence of hydrochloric acid in tetrahydrofurane isomerizes into d,l-9(11)-dehydroestrone, melting point 262°-265°C (from alcohol).
Hydrogenation of d,l-9(11)-dehydroestrone in tetrahydrofuran in the presence of Pd/CaCO3 yields the estrone, melting point 251°-252°C (from acetone).

brand name

Estrogenic Substance (Wyeth); Theelin (Parkdale).

Therapeutic Function

Estrogen

General Description

Estrone, 3-hydroxyestra-1,3,5(10)-trien-17-one, is less active than estradiol but more active than itsmetabolite, estriol. As the salt of its 3-sulfate ester, estroneis the primary ingredient in conjugated estrogens, USP, andesterified estrogens, USP. Although originally obtainedfrom the urine of pregnant mares (about 10 mg/L), estroneis now prepared synthetically. Estrone itself is not availablein commercial oral formulations, but can be obtained at compounding pharmacies as a topical formulation. Oleoylestrone,the C3 ester of estrone with oleic acid, is in phase IIclinical trials for the treatment of obesity. This acyl estronederivative reduces fat stores by a mechanism not involvingthe ER, although some of the oleoyl-estrone is hydrolyzedto estrone in vivo.

Hazard

A carcinogen (OSHA).

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A poison by intraperitoneal and subcutaneous routes. Human reproductive effects by implantation: spermatogenesis and impotence. Mutation data reported. A steroid drug for the treatment of menopause and ovariectomy symptoms. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

Estrone, 3-hydroxyestra-1,3,5(10)-trien-17-one (28.1.9), has been made synthetically in various ways. According to one of the first and most simple schemes, synthesis was carried out in the following manner. Condensation of 3-methoxyphenylacetylene with bicyclohexane-1,5-dione in a Favorskii reaction conditions lead to the corresponding carbinol (28.1.1). The triple bond was reduced by hydrogen over a palladium catalyst, forming the tertiary alcohol (28.1.2), which was then dehydrated in acidic conditions to give the compound (28.1.3). Intramolecular alkylation of this compound in the presence of anhydrous aluminum chloride formed a tetracyclic ketone (28.1.4), which during condensation with benzaldehyde was transformed into an eneone (28.1.5). This was methylated at the |?-position relative to the keto-group by methyl iodide in the presence of potassium tert-butylate, and the resulting compound (28.1.6) underwent ozonolysis, forming the dicarboxylic acid (28.1.7). Cyclization of this compound to a cyclopentanone derivative lead to the formation of methyl ester of the desired estrone (28.1.8), and demethylation of the phenolic hydroxyl group by hydrobromic acid formed the desired estrone (28.1.9).

Potential Exposure

Synthesized from ergosterol. Used in combination with progestogen as an oral contraceptive.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, well-ventilated area. A regulated, marked area should be established where this chemical is handled, used, or stored incompliance with OSHA Standard 1910.1045.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Purify estrone by chromatography on silica gel, eluting with 2:1 hexane/EtOAc and recrystallising from EtOH or Et2O/EtOH. [Danishefsky & Cain J Am Chem Soc 98 4975 1976.] The acetate [901-93-9] crystallises from EtOH with m 125-127o. [Beilstein 8 III 1171.]

Incompatibilities

May react exothermically with reducing agents to generate flammable gaseous hydrogen. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

Estrone Preparation Products And Raw materials

Raw materials

CHLORIC ACID Ring compound 5-ALPHA-ANDROSTANE Dibromo Acetylacetone Isopropyl acetate 2,4,6-Collidine

Preparation Products

Ethinyl Estradiol Estriol β-Estradiol Oxendolone estra-1,3,5(10),16-tetraene-3,17-diol diacetate 16,17-Epoxy-3,17-dihydroxyestra-1,3,5(10)-triene-3,17-diacetate

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View Lastest Price from Estrone manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Estrone 53-16-7
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97.0～103.0%; USP41
Supply Ability: 1200kg/month
Release date: 2021-06-05

hebei hongtan Biotechnology Co., Ltd

Product: Estrone 53-16-7
Price: US $30.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-21

Hebei Weibang Biotechnology Co., Ltd

Product: 1,3,5(10)-Estratrien-3-ol-17-one 53-16-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

53-16-7, EstroneRelated Search:

1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin

3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one

Estropipate (Estrone)

Estrone,1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin

Estrone (200 mg)

Estrone, Plant Base, USP

ESTRA-1,3,5(10)-TRIEN-3-OL-17-ONE

OESTRON

3-Hydroxy-1,3,5(10)-estrareien-17-one

Estrone Estrovarin

ESTRONE USP 23

ketohydrocyestrin

wynestrone

Estronel

Ethinylestradiol EP IMpurity C

(8R,9S,13S,14S)-3-hydroxy-13-Methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

(1S,10R,11S,15S)-5-hydroxy-15-Methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one

3-Hydroxy-17-ketooestra-1,3,5-triene

3-Hydroxyestra-1(10),2,4-trien-17-one

3-Hydroxyestra-1,3,5(10)-17-one

3-Hydroxyestra-1,3,5(10)-triene-17-one

3-Hydroxy-oestra-1,3,5(10)-trien-17-one

5(10)-trien-17-one,3-hydroxy-estra-3

Aquacrine

component of Spanestrin-P

Crinovaryl

Cristallovar

Crystogen

delta-1,3,5-estratrien-3-beta-ol-17-one

delta-1,3,5-Estratrien-3beta-ol-17-one

delta-1,3,5-oestratrien-3-beta-ol-17-one

Conjugated Estrogens EP Impurity B

200-164-5

(8R,13S)-3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-cyclopenta[a]phenanthren-17-one

1,3,5(10)-Oestratrien-3-ol-17-one

1,3,5-Oestratrien-3-ol-17-one

delta-1,3,5-Oestratrien-3beta-ol-17-one

Disynformon

E(sub 1)

e(sub1)

Endofolliculina

Esterone

Estra-1,3,5(10)-trien-17-one, 3-hydroxy-

Estrin

Estron

Estrona

Estrone-A

EstroneI

Estrovarin

Estrugenone

Estrusol

Femestrone inj.

Femestrone injection

Menagen

Menformon

Menformon A

Mestronaq

Oestroperos