4-HYDROXYESTRONE

Product Name: 4-HYDROXYESTRONE
CAS No.: 3131-23-5
Chemical Name: 4-HYDROXYESTRONE
Synonyms: 4-OH-E1;4-HYDROXYESTRONE;Estrone Impurity 8;Estrone 4-Hydroxy Impurity;1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE;1,3,5[10]-ESTRATRIENE-3,4-DIOL-17-ONE;5(10)-trien-17-one,3,4-dihydroxy-estra-3;3,4-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE;3,4-dihydroxyestra-1,3,5(10)-trien-17-one;3,4-Dihydroxyestra-1(10),2,4-triene-17-one
CBNumber: CB4353324
Molecular Formula: C18H22O3
Formula Weight: 286.37
MOL File: 3131-23-5.mol

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4-HYDROXYESTRONE Property

Melting point:: 260-263°C
Boiling point:: 468.2±45.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
Flash point:: 93 °C
storage temp.: −20°C
solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form: Solid
pka: 10.06±0.40(Predicted)
color: Pale Yellow to Light Brown

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Safety

WGK Germany: 3
RTECS: KG7749500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H6012
Product name: 4-Hydroxyestrone
Purity: ≥90% (HPLC)
Packaging: 5mg
Price: $242
Updated: 2024/03/01

Sigma-Aldrich

Product number: H6012
Product name: 4-Hydroxyestrone
Purity: ≥90% (HPLC)
Packaging: 25mg
Price: $956
Updated: 2024/03/01

TRC

Product number: H941950
Product name: 4-HydroxyEstrone
Packaging: 5mg
Price: $130
Updated: 2021/12/16

TRC

Product number: H941950
Product name: 4-HydroxyEstrone
Packaging: 50mg
Price: $870
Updated: 2021/12/16

Usbiological

Product number: 279091
Product name: 4-Hydroxy estrone
Packaging: 1mg
Price: $425
Updated: 2021/12/16

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4-HYDROXYESTRONE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

A metabolite of Estradiol.

Definition

ChEBI: A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4.

Hazard

A reproductive hazard.

Biochem/physiol Actions

4-Hydroxyestrone is an endogenous estrogen metabolite, which exhibits a strong neuroprotective effect against oxidative damage. It also provides effective protection against kanic acid-induced hippocampal oxidative damage in rats when compared to 17β-estradiol. 4-Hydroxyestrone regulates the angiogenic process during corpus luteum formation. It might be involved in an increased risk of cancer. 4-Hydroxyestrone is found in the early and mid-luteal phases.

4-HYDROXYESTRONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYESTRONE Suppliers

Canada 1 China 26 Germany 1 India 4 Switzerland 1 United Kingdom 1 United States 9 Global 43

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9685
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ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
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Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
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Shandong JunRui Pharmaceutical Co., Ltd.

Tel: 0539-5636807 15318528770
Fax: 0539-5636807
Email: ffeng813@qq.com
Country: China
ProdList: 247
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Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15952
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
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Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
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Country: CHINA
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Qingdao Tenglong microwave technology co., LTD.

Tel: 0532-83818797 18561885118
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3131-23-5, 4-HYDROXYESTRONERelated Search:

1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE 4-METHYL ETHER 4-METHOXYESTRONE-1,2,16,16-D4 4-HYDROXYESTRONE-1,2,16,16-D4 4-HYDROXYESTRONE 6-hydroxyestrone 16a-Hydroxyestrone 16-b-D-Glucuronide,16a-Hydroxyestrone 16-Glucuronoside,16a-Hydroxyestrone 16--D-Glucuronide 2-HYDROXYESTRONE-3-METHYL ETHER 16ALPHA-HYDROXYESTRONE,16A-hydroxyestrone 2-HYDROXYESTRONE-1,4,16,16-D4 11B-Hydroxyestrone,11-hydroxyestrone,11-BETA-HYDROXYESTRONE 4-hydroxyestrone-4-methyl ether 2-HYDROXYESTRONE N-2-Hydroxyestrone-N-ethanesulfic Acid-D18 16B-Hydroxyestrone 3,16-diacetate,16B-HYDROXYESTRONE DIACETATE 2-HYDROXYESTRONE 2-METHYL ETHER 16b-Hydroxyestrone 2,4-Dibromo-16a-hydroxyestrone Hydroxyestrone

1,3,5[10]-ESTRATRIENE-3,4-DIOL-17-ONE

1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE

3,4-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE

4-HYDROXYESTRONE

3,4-dihydroxyestra-1,3,5(10)-trien-17-one

5(10)-trien-17-one,3,4-dihydroxy-estra-3

(9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

Estrone 4-Hydroxy Impurity

3,4-Dihydroxy-1(10),2,4-estratriene-17-one

3,4-Dihydroxyestra-1(10),2,4-triene-17-one

4-OH-E1

Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-

Estrone Impurity 8

(8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

3131-23-5

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids