1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

Product Name: 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
CAS No.: 566-76-7
Chemical Name: 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
Synonyms: C05300;16α-OHE1;16A-hydroxyestrone;Estriol Impurity H;16α-hydroxy Estrone;Hydroxyestrone, 16α-;Estriol EP Impurity H;16ALPHA-HYDROXYESTRONE;16ALPHA-HYDROXYESTERONE;16α-Hydroxyestrone (solution)
CBNumber: CB9688380
Molecular Formula: C18H22O3
Formula Weight: 286.37
MOL File: 566-76-7.mol

More

Less

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Property

Melting point:: 209-211°C
Boiling point:: 493.2±45.0 °C(Predicted)
Density: 1.249±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 10.23±0.60(Predicted)
color: White to Light Beige

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 40
Safety Statements: 22-36
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H-126
Product name: 16α-Hydroxyestrone
Purity: 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?
Packaging: 1ML
Price: $462
Updated: 2022/05/15

Cayman Chemical

Product number: 15208
Product name: 16α-hydroxy Estrone
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 15208
Product name: 16α-hydroxy Estrone
Purity: ≥98%
Packaging: 5mg
Price: $423
Updated: 2024/03/01

Cayman Chemical

Product number: 15208
Product name: 16α-hydroxy Estrone
Purity: ≥98%
Packaging: 10mg
Price: $662
Updated: 2024/03/01

TRC

Product number: H941900
Product name: 16α-HydroxyEstrone
Packaging: 10mg
Price: $550
Updated: 2021/12/16

More

Less

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Chemical Properties,Usage,Production

Description

The naturally-occurring estrogens are estrone (E₁, ), estradiol (E₂, ), and estriol (E₃, ). 16α-hydroxy Estrone (16α-OHE₁) is a hydroxylated metabolite of E₁ as well as an interconversion product with E₂. E₁ is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE₁ is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E₁, 16α-OHE₁ binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE₁ are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE₁ has been implicated as a risk factor for breast cancer, although supportive data remains elusive.

Chemical Properties

Pale Pink Solid

Uses

16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol.

Definition

ChEBI: The 16alpha-hydroxy derivative of estrone; a minor estrogen metabolite.

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Suppliers

Canada 2 China 36 India 4 Switzerland 1 United Kingdom 1 United States 13 Global 57

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

Alta Scientific Co., Ltd.

Tel: 022-6537-8550 15522853686
Fax: 022-2532-9655
Email: sales@altasci.com.cn
Country: China
ProdList: 4511
Advantage: 55

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 15319487004
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 4084
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

566-76-7, 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONERelated Search:

Estrone 16B-HYDROXYESTRONE DIACETATE 1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE 3-ACETATE 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

16A-hydroxyestrone

(16a)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one

3,16a-Dihydroxy-1,3,5(10)-estratrien-17-one

Estra-1,3,5(10)-triene-3,16a-diol-17-one

16ALPHA-HYDROXYESTERONE

16ALPHA-HYDROXYESTRONE

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE

3,16ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE

(16R)-3,16α-Dihydroxy-1,3,5(10)-estratriene-17-one

16α-OHE1

3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one

C05300

(16α)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one

Estra-1,3,5(10)-triene-3,16α-diol-17-one

1,3,5(10)-Estratriene-3,16α-diol-17-one

Conjugated Estrogens EP Impurity H

(8R,9S,13S,14S,16R)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

16α-Hydroxyestrone Solution, 100ppm

Estriol EP Impurity H

Hydroxyestrone, 16α-

16α-Hydroxyestrone (solution)

Estra-1,3,5(10)-trien-17-one, 3,16-dihydroxy-, (16α)-

16α-hydroxy Estrone

Estriol Impurity 8 (Estriol EP Impurity H)

16α-Hydroxyestrone Solution, 100ppm

(8R,9S,13S,14S,16R)-3,16-Dihydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

Estriol Impurity H

1, 3, 5(10)-ESTRATRIEN-3, 16α-DIOL-17-ONE

16α-Hydroxyestrone in Methanol

566-76-7

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids