ChemicalBook > CAS DataBase List > 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

Product Name
1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
CAS No.
566-76-7
Chemical Name
1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
Synonyms
C05300;16α-OHE1;16A-hydroxyestrone;Estriol Impurity H;16α-hydroxy Estrone;Hydroxyestrone, 16α-;Estriol EP Impurity H;16ALPHA-HYDROXYESTRONE;16ALPHA-HYDROXYESTERONE;16α-Hydroxyestrone (solution)
CBNumber
CB9688380
Molecular Formula
C18H22O3
Formula Weight
286.37
MOL File
566-76-7.mol
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1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Property

Melting point:
209-211°C
Boiling point:
493.2±45.0 °C(Predicted)
Density 
1.249±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
10.23±0.60(Predicted)
color 
White to Light Beige
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H-126
Product name
16α-Hydroxyestrone
Purity
100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?
Packaging
1ML
Price
$462
Updated
2022/05/15
Cayman Chemical
Product number
15208
Product name
16α-hydroxy Estrone
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
15208
Product name
16α-hydroxy Estrone
Purity
≥98%
Packaging
5mg
Price
$423
Updated
2024/03/01
Cayman Chemical
Product number
15208
Product name
16α-hydroxy Estrone
Purity
≥98%
Packaging
10mg
Price
$662
Updated
2024/03/01
TRC
Product number
H941900
Product name
16α-HydroxyEstrone
Packaging
10mg
Price
$550
Updated
2021/12/16
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1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Chemical Properties,Usage,Production

Description

The naturally-occurring estrogens are estrone (E1, ), estradiol (E2, ), and estriol (E3, ). 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.

Chemical Properties

Pale Pink Solid

Uses

16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol.

Definition

ChEBI: The 16alpha-hydroxy derivative of estrone; a minor estrogen metabolite.

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Suppliers

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566-76-7, 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONERelated Search:

Estrone 16B-HYDROXYESTRONE DIACETATE 1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE 3-ACETATE 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

  • 16A-hydroxyestrone
  • (16a)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
  • 3,16a-Dihydroxy-1,3,5(10)-estratrien-17-one
  • Estra-1,3,5(10)-triene-3,16a-diol-17-one
  • 16ALPHA-HYDROXYESTERONE
  • 16ALPHA-HYDROXYESTRONE
  • 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
  • 1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE
  • 3,16ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE
  • (16R)-3,16α-Dihydroxy-1,3,5(10)-estratriene-17-one
  • 16α-OHE1
  • 3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one
  • C05300
  • (16α)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
  • Estra-1,3,5(10)-triene-3,16α-diol-17-one
  • 1,3,5(10)-Estratriene-3,16α-diol-17-one
  • Conjugated Estrogens EP Impurity H
  • (8R,9S,13S,14S,16R)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
  • 16α-Hydroxyestrone Solution, 100ppm
  • Estriol EP Impurity H
  • Hydroxyestrone, 16α-
  • 16α-Hydroxyestrone (solution)
  • Estra-1,3,5(10)-trien-17-one, 3,16-dihydroxy-, (16α)-
  • 16α-hydroxy Estrone
  • Estriol Impurity 8 (Estriol EP Impurity H)
  • 16α-Hydroxyestrone Solution, 100ppm
  • (8R,9S,13S,14S,16R)-3,16-Dihydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one
  • Estriol Impurity H
  • 1, 3, 5(10)-ESTRATRIEN-3, 16α-DIOL-17-ONE
  • 566-76-7
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids