PTIO

Product Name: PTIO
CAS No.: 18390-00-6
Chemical Name: PTIO
Synonyms: PTIO;PTIO,98%;PTIO PTIO - CAS 18390-00-6;PTIO - CAS 18390-00-6 - Calbiochem;2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL;2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE;PTIO (2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL);4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-2-PHENYL-1H-IMIDAZOL-1-YLOXY-1-OXIDE;[[4,4,5,5-Tetramethyl-2-phenyl-2-imidazoline 3-oxide]-1-yloxy]radical
CBNumber: CB5747094
Molecular Formula: C13H17N2O2
Formula Weight: 233.29
MOL File: 18390-00-6.mol

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PTIO Property

Melting point:: approximate 86℃
storage temp.: 2-8°C
solubility: soluble in Methanol
form: Dark blue solid
color: Blue to Dark blue
InChI: InChI=1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3
InChIKey: DYUUGILMVYJEHY-UHFFFAOYSA-N
SMILES: C1(C)(C)N([O])C(C2C=CC=CC=2)=[N+]([O-])C1(C)C |^1:4|

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933.99.8210

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P5084
Product name: PTIO
Packaging: 25mg
Price: $205
Updated: 2025/07/31

Sigma-Aldrich

Product number: 523350
Product name: PTIO
Purity: Nitric oxide radical scavenger.
Packaging: 25mg
Price: $159
Updated: 2025/07/31

TCI Chemical

Product number: A5440
Product name: PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]
Purity: >98.0%(T)
Packaging: 1g
Price: $150
Updated: 2025/07/31

TCI Chemical

Product number: A5440
Product name: PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]
Purity: >98.0%(T)
Packaging: 5g
Price: $450
Updated: 2025/07/31

Cayman Chemical

Product number: 14982
Product name: PTIO
Purity: ≥98%
Packaging: 25mg
Price: $37
Updated: 2024/03/01

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PTIO Chemical Properties,Usage,Production

Description

PTIO is an oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. It can be used to assay nitric oxide production when examining nitric oxide synthase inhibitory activity.

Chemical Properties

blue crystals

Uses

PTIO is a nitric oxide (NO) radical scavenger used to inhibit physiological effects of NO.

Uses

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 1078, 1968 DOI: 10.1021/ja01006a053

General Description

Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors.

Biochem/physiol Actions

Product does not compete with ATP.

References

[1] SARA GOLDSTEIN Amram S Angelo Russo. Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.[J]. The Journal of Biological Chemistry, 2003, 278 51: 50949-50955. DOI: 10.1074/jbc.m308317200
[2] N NAKATSUBO. Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors.[J]. Biological & pharmaceutical bulletin, 1998, 21 12: 1247-1250. DOI: 10.1248/bpb.21.1247

PTIO Preparation Products And Raw materials

Raw materials

Preparation Products

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PTIO Suppliers

Americas 1 China 101 Europe 1 Germany 2 India 2 Japan 4 Switzerland 2 United Kingdom 1 United States 10 Global 124

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

Nacalai Tesque, Inc.

Tel: --
Fax: --
Email: info-tech@nacalai.co.jp
Country: Japan
ProdList: 6046
Advantage: 75

Kanto Chemical Co., Inc.

Tel: --
Fax: --
Email: reag-info@gms.kanto.co.jp
Country: Japan
ProdList: 6756
Advantage: 74

Wako Pure Chemical Industries, Ltd.

Tel: --
Fax: --
Email: labchem-tec@wako-chem.co.jp
Country: Japan
ProdList: 6819
Advantage: 80

18390-00-6, PTIORelated Search:

Oxazoline 2-Phenyl-2-imidazoline PTIO 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, NA 2-(4-NITROPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL 3,3,4,4-TETRAMETHYL-2-TRIMETHYLAMMONIOPHENYL-2-IMIDAZOLINE-3-OXIDE-1-YLOXY CHLORIDE 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide CARBOXY-PTIO 1H-IMIDAZOL-1-YLOXY, 2-(1,3-BENZODIOXOL-5-YL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-, 3-OXIDE

2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl)[stablefreeradicalreagentforthesimultaneousdetermin

2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE

2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL

PTIO

PTIO (2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL)

PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]

[(2-Phenyl-4,4,5,5-tetramethyl-3-oxylato-4,5-dihydro-1H-imidazole-3-ium)-1-yloxy]radical

[(4,5-Dihydro-2-phenyl-4,4,5,5-tetramethyl-1H-imidazole-3-oxide)-1-yloxy]radical

[[(2-Phenyl-3-oxylato-4,4,5,5-tetramethyl-1H-imidazole-3-ium)-1-yl]oxy]radical

[[2-Phenyl-4,4,5,5-tetramethyl-2-imidazoline 3-oxide]-1-yloxy]radical

[[4,4,5,5-Tetramethyl-2-phenyl-2-imidazoline 3-oxide]-1-yloxy]radical

PTIO,98%

4,5-Dihydro-4,4,5,5-tetramethyl-2-phenyl-1H-imidazol-1-yloxy-1-oxide 2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl

(=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]

PTIO&nbsp

PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO<sub>2</sub> in the atmosphere]

4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-2-PHENYL-1H-IMIDAZOL-1-YLOXY-1-OXIDE

PTIO - CAS 18390-00-6 - Calbiochem

PTIO（4,5-Dihydro-4,4,5,5-tetramethyl-2-phenyl-1H-imidazol-1-yloxy-1-oxide）

PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl)[Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]&gt

PTIO - CAS 18390-00-6

1H-Imidazol-1-yloxy, 4,5-dihydro-4,4,5,5-tetramethyl-2-phenyl-, 3-oxide

18390-00-6

C13H17N2O2

Nitric Oxide Metabolism

Enzymes, Inhibitors, and Substrates

Nitric Oxide Scavengers

BioChemical

Biochemicals and Reagents

Application Index

Cell Signaling Enzymes