ChemicalBook > CAS DataBase List > Carmofur

Carmofur

Product Name
Carmofur
CAS No.
61422-45-5
Chemical Name
Carmofur
Synonyms
hcfu;HCFUTM;Mifurol;CARMOFUR;Carmofur >Carmofur Carmofur;Carmofur, ≥ 98.0%;Carmofur USP/EP/BP;Carmofur, Antimetabolite agent;5-FLUORO-1-HEXYLCARBAMOYLURACIL
CBNumber
CB5748051
Molecular Formula
C11H16FN3O3
Formula Weight
257.26
MOL File
61422-45-5.mol
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Carmofur Property

Melting point:
110-111
Density 
1.2287 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: >15mg/mL
form 
powder
pka
6.94±0.10(Predicted)
color 
white to off-white
Merck 
14,1844
CAS DataBase Reference
61422-45-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
60-61-25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
UV7714000
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1494
Product name
Carmofur
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$95.3
Updated
2024/03/01
Sigma-Aldrich
Product number
C1494
Product name
Carmofur
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$388
Updated
2024/03/01
TCI Chemical
Product number
C2663
Product name
Carmofur
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$621
Updated
2024/03/01
Cayman Chemical
Product number
14243
Product name
Carmofur
Purity
≥98%
Packaging
1g
Price
$105
Updated
2024/03/01
Cayman Chemical
Product number
14243
Product name
Carmofur
Purity
≥98%
Packaging
5g
Price
$274
Updated
2024/03/01
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Carmofur Chemical Properties,Usage,Production

Description

Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.

Originator

Mifurol,Mitsui,Japan,1981

Uses

antineoplastic

Uses

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Definition

ChEBI: Carmofur is an organohalogen compound and a member of pyrimidines.

Manufacturing Process

13.0 g (0.10 mol) of 5-fluorouracil was suspended in 60 ml of dimethyl acetamide, then 14.0 g (0.11 mol) of n-hexyl isocyanate was added thereto at room temperature and stirred at 50°C for 8 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into 400 ml of water and resultant precipitate was filtered off. The precipitate was washed and dried and 19.3 g (75.0% yield) of 5-fluoro-1-(n-hexylcarbamoyl)uracil was obtained.
The product was recrystallized from ether and there were obtained white crystals melting at 283°C (decomposition).

Therapeutic Function

Antineoplastic

Biochem/physiol Actions

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur Preparation Products And Raw materials

Raw materials

Preparation Products

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Carmofur Suppliers

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J & K SCIENTIFIC LTD.
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View Lastest Price from Carmofur manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Carmofur 61422-45-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Carmofur 61422-45-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Dideu Industries Group Limited
Product
Carmofur 61422-45-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01

61422-45-5, CarmofurRelated Search:

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  • 2,4-dioxo-5-fluoro-n-hexyl-1,2,3,4-tetrahydro-1-pyrimidinecarboxamide
  • 2,4-dioxo-5-fluoro-n-hexyl-3,4-dihydro-1(2h)-pyrimidinecarboxamidme
  • 3,4-dihydro-2,4-dioxo-5-fluoro-n-hexyl-1(2h)-pyrimidinecarboxamid
  • hcfu
  • 5-FLUORO-1-HEXYLCARBAMOYLURACIL
  • CARMOFUR
  • HCFUTM
  • 1-(N-HEXYLCARBAMOYL)-5-FLUOROURACIL
  • 1(2H)-Pyrimidinecarboxamide, 3,4-dihydro-2,4-dioxo-5-fluoro-N-hexyl
  • 1-(Hexylcarbamyl)-5-fluorouracil
  • 5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinecarboxamide
  • Mifurol
  • HCFUTM, 3,4-Dihydro-2,4-dioxo-5-fluoro-N-hexylpyrimidine-1(2H)-carboxamide
  • 5-fluoro-N-hexyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-1-carboxaMide
  • 5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide
  • 1,2,3,4-tetrahydro-2,4-dioxo-5-fluoro-n-hexyl-1-pyrimidinecarboxamid
  • 1-hexylcarbamoyl-5-fluorouracil
  • Carmofur &gt
  • Carmofur Carmofur
  • 1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-
  • Carmofur USP/EP/BP
  • 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide
  • Carmofur, ≥ 98.0%
  • Carmofur, Antimetabolite agent
  • 61422-45-5
  • C11H16FN3O3
  • Pharmaceutical material and intermeidates