Carmofur

ChemicalBook > CAS DataBase List > Carmofur

Product Name: Carmofur
CAS No.: 61422-45-5
Chemical Name: Carmofur
Synonyms: hcfu;HCFUTM;Mifurol;CARMOFUR;Carmofur >Carmofur Carmofur;Carmofur, ≥ 98.0%;Carmofur USP/EP/BP;5-FLUORO-1-HEXYLCARBAMOYLURACIL;1-hexylcarbamoyl-5-fluorouracil
CBNumber: CB5748051
Molecular Formula: C11H16FN3O3
Formula Weight: 257.26
MOL File: 61422-45-5.mol

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Carmofur Property

Melting point:: 110-111
Density: 1.2287 (estimate)
storage temp.: 2-8°C
solubility: DMSO: >15mg/mL
form: powder
pka: 6.94±0.10(Predicted)
color: white to off-white
Merck: 14,1844
CAS DataBase Reference: 61422-45-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 60-61-25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGII
WGK Germany: 3
RTECS: UV7714000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C1494
Product name: Carmofur
Purity: ≥98% (HPLC), powder
Packaging: 10mg
Price: $95.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: C1494
Product name: Carmofur
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $388
Updated: 2024/03/01

TCI Chemical

Product number: C2663
Product name: Carmofur
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $621
Updated: 2024/03/01

Cayman Chemical

Product number: 14243
Product name: Carmofur
Purity: ≥98%
Packaging: 1g
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 14243
Product name: Carmofur
Purity: ≥98%
Packaging: 5g
Price: $274
Updated: 2024/03/01

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Carmofur Chemical Properties,Usage,Production

Description

Carmofur is an inhibitor of acid ceramidase (IC₅₀ = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC₅₀ = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.

Originator

Mifurol,Mitsui,Japan,1981

Uses

antineoplastic

Uses

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Definition

ChEBI: Carmofur is an organohalogen compound and a member of pyrimidines.

Manufacturing Process

13.0 g (0.10 mol) of 5-fluorouracil was suspended in 60 ml of dimethyl acetamide, then 14.0 g (0.11 mol) of n-hexyl isocyanate was added thereto at room temperature and stirred at 50°C for 8 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into 400 ml of water and resultant precipitate was filtered off. The precipitate was washed and dried and 19.3 g (75.0% yield) of 5-fluoro-1-(n-hexylcarbamoyl)uracil was obtained.
The product was recrystallized from ether and there were obtained white crystals melting at 283°C (decomposition).

Therapeutic Function

Antineoplastic

Biochem/physiol Actions

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carmofur manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carmofur 61422-45-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Carmofur 61422-45-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Dideu Industries Group Limited

Product: Carmofur 61422-45-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

61422-45-5, CarmofurRelated Search:

Capecitabine Bortezomib Degrasyn (WP1130) Gefitinib Panobinostat DAPT Doxorubicin hydrochloride SULFURYL FLUORIDE 5-Fluorouracil Fluorocytosine 5-Fluoropyrimidine 2-Thiouracil Semicarbazide L-ACYLASE Fluorine Carmofur UK 25

2,4-dioxo-5-fluoro-n-hexyl-1,2,3,4-tetrahydro-1-pyrimidinecarboxamide

2,4-dioxo-5-fluoro-n-hexyl-3,4-dihydro-1(2h)-pyrimidinecarboxamidme

3,4-dihydro-2,4-dioxo-5-fluoro-n-hexyl-1(2h)-pyrimidinecarboxamid

hcfu

5-FLUORO-1-HEXYLCARBAMOYLURACIL

CARMOFUR

HCFUTM

1-(N-HEXYLCARBAMOYL)-5-FLUOROURACIL

1(2H)-Pyrimidinecarboxamide, 3,4-dihydro-2,4-dioxo-5-fluoro-N-hexyl

1-(Hexylcarbamyl)-5-fluorouracil

5-Fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinecarboxamide

Mifurol

HCFUTM, 3,4-Dihydro-2,4-dioxo-5-fluoro-N-hexylpyrimidine-1(2H)-carboxamide

5-fluoro-N-hexyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-1-carboxaMide

5-fluoro-N-hexyl-2,4-dioxo-3,4-dihydropyrimidine-1(2H)-carboxamide

1,2,3,4-tetrahydro-2,4-dioxo-5-fluoro-n-hexyl-1-pyrimidinecarboxamid

1-hexylcarbamoyl-5-fluorouracil

Carmofur &gt

Carmofur Carmofur

1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-

Carmofur USP/EP/BP

5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide

Carmofur, ≥ 98.0%

61422-45-5

C11H16FN3O3

Pharmaceutical material and intermeidates