ChemicalBook > CAS DataBase List > 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT

1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT

Product Name
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT
CAS No.
14982-12-8
Chemical Name
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT
Synonyms
17-BETA-ESTRADIOL 3-GLUCURONIDE;SodiuM 17-Estradiol-d3 3-Glucuronide;17B-estradiol 3-(B-D-glucuronide)*sodium;Estradiol 3-(β-D-Glucuronide) sodium salt;Estradiol 3-O-β-D-glucuronide sodium salt;Estradiol 3-O-b-D-glucuronide sodium salt;17β-Estradiol 3-β-D-Glucuronide Sodium Salt;b-Estradiol 3-(b-D-glucuronide) sodium salt;oestradiol 3-(beta-D-glucuronide), sodium salt;β-Estradiol 3-(β-D-glucuronide) sodium salt
CBNumber
CB5751040
Molecular Formula
C24H31NaO8
Formula Weight
470.49
MOL File
14982-12-8.mol
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1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT Property

storage temp. 
−20°C
solubility 
≤20mg/ml in DMSO;10mg/ml in dimethyl formamide
form 
crystalline solid
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
22-36
WGK Germany 
3
HS Code 
2938909090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E2127
Product name
β-Estradiol 3-(β-D-glucuronide) sodium salt
Packaging
5mg
Price
$287
Updated
2024/03/01
Sigma-Aldrich
Product number
E2127
Product name
β-Estradiol 3-(β-D-glucuronide) sodium salt
Packaging
10mg
Price
$509
Updated
2024/03/01
Cayman Chemical
Product number
16155
Product name
Estradiol 3-(β-D-Glucuronide) (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
16155
Product name
Estradiol 3-(β-D-Glucuronide) (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$252
Updated
2024/03/01
Sigma-Aldrich
Product number
E2127
Product name
β-Estradiol 3-(β-D-glucuronide) sodium salt
Packaging
25mg
Price
$1070
Updated
2024/03/01
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1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT Chemical Properties,Usage,Production

Uses

beta-Estradiol 3-(beta-D-glucuronide) sodium salt is a non-cholestatic regioisomer of the estrogen metabolite, estradiol 17-(β-D-glucuronide).

Uses

β-Estradiol 3-(β-D-glucuronide) sodium salt has been used in estrogen administration. It has also been used to determine the amount of two types of glucuronidated estradiols such as estradiol-3- α glucuronide and estradiol-17- β glucuronide.

Biological Activity

β-estradiol 3-(β-d-glucuronide) (e23g) is a noncholestatic regioisomer of the estrogen metabolite, e217g (β-estradiol 17-(β-d-glucuronide)) [1]. e23g functions as a substrate for multidrug resistance associated protein 2 (mrp2) [2].mrp2 is a member of the mrp subfamily, belongs to the superfamily of atp-binding cassette (abc) transporters. mrp2 has been expressed in the canalicular (apical) part of the hepatocyte involved in multi-drug resistance, and functions in biliary transport [3].

in vitro

in sf9 cells infected with the recombinant baculovirus of which baculovirus genome containing rat mrp2, e23g (0.4-400 μm) completely and competitively inhibited e217g transport with an ic50 value of 14.2 μm. doses of e217g at 0.01-250 μm inhibited only 53% of e23g transport with an ic50 of 33.4 μm [1]. it has been reported e23g inhibited e217g transport through rat organic anion-transporting polypeptide 1 with a ki value of 9.7 μm. e23g was a low-affinity inhibitor of both mrp4 and mrp7 with ic50s of ~ 100 μm. the noncholestatic e23g behaved as an mrp2 substrate which could compete with e217g for transport, but did not activate the allosteric site. in sf9 cell membranes expressing multidrug resistance protein 2 (mrp2), e23g functioned as a substrate for mrp2 with km of 122 μm, competing with e217g for mrp2-mediated transport [3].

References

[1] gerk p m, li w, vore m. estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide[j]. drug metabolism and disposition, 2004, 32(10): 1139-1145.
[2] gerk p m, li w, megaraj v, et al. human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate[j]. journal of pharmacology and experimental therapeutics, 2007, 320(2): 893-899.
[3] borst p, evers r, kool m, et al. the multidrug resistance protein family[j]. biochimica et biophysica acta (bba)-biomembranes, 1999, 1461(2): 347-357.

1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT Suppliers

Clearsynth Labs Limited
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orderCN@merckgroup.com
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China
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14982-12-8, 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALTRelated Search:


  • 3,17BETA-DIHYDROXY-1,3,5[10]-ESTRATRIENE 3-GLUCURONIDE SODIUM SALT
  • 17BETA-ESTRADIOL 3-(BETA-D-GLUCURONIDE) SODIUM SALT
  • 17-BETA-ESTRADIOL 3-GLUCURONIDE
  • 1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL 3-GLUCOSIDURONATE, SODIUM SALT
  • 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-GLUCURONIDE SODIUM SALT
  • 17B-estradiol 3-(B-D-glucuronide)*sodium
  • oestradiol 3-(beta-D-glucuronide), sodium salt
  • 1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide
  • β-Estradiol 3-(β-D-glucuronide) sodium salt
  • 17β-Estradiol 3-β-D-Glucuronide Sodium Salt
  • SodiuM 17-Estradiol-d3 3-Glucuronide
  • 1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide
  • 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide
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  • .beta.-Estradiol 3-(.beta.-D-Glucuronide) (sodium salt)
  • Estradiol 3-(β-D-Glucuronide) sodium salt
  • Estradiol 3-O-β-D-glucuronide sodium salt
  • b-Estradiol 3-(b-D-glucuronide) sodium salt
  • Estradiol 3-O-b-D-glucuronide sodium salt
  • 1, 3, 5(10)-ESTRATRIEN-3, 17β-DIOL 3-GLUCOSIDURONATE, SODIUM SALT
  • 14982-12-8
  • Hormones
  • Estrogen
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Cytokines, Growth Factors and Hormones
  • Steroid Hormones