19(R)-HYDROXY PROSTAGLANDIN F2ALPHA Property

solubility 

10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: >10 mg/ml

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

19(R)-HYDROXY PROSTAGLANDIN F2ALPHA Chemical Properties,Usage,Production

Description

19(R)-hydroxy PGF_2α is an ω-1 hydroxylase metabolite of PGF_2α found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F_2α and F_1α together) in fresh human semen is about 20 μg/ml.¹ 19(R)-hydroxy PGF_2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.²

Definition

ChEBI: 19R-Hydroxy-PGF2alpha is a prostanoid.

References

1. Taylor, P.L., and Kelly, R.W. The occurrence of 19-hydroxy F prostaglandins in human semen FEBS Lett. 57(1),22-25(1975).
2. Woodward, D.F., Protzman, C.E., Krauss, A.H.P., et al. Identification of 19(R)-OH prostaglandin E₂ as a selective prostanoid EP₂-receptor agonist Prostaglandins 46(4),371-383(1993).