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Dinoprost tromethamine

Product Name
Dinoprost tromethamine
CAS No.
38562-01-5
Chemical Name
Dinoprost tromethamine
Synonyms
583e;u14585;lutalyse;PGF2αTris;Ensaprost;u-14,583e;PGF2ALPHA;Zinoprost;PGF2a-THAM;THAM PGF2α
CBNumber
CB9394313
Molecular Formula
C24H45NO8
Formula Weight
475.62
MOL File
38562-01-5.mol
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Dinoprost tromethamine Property

Melting point:
100-101°
storage temp. 
-20°C
solubility 
H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.
form 
powder
color 
white
Merck 
13,7970
BRN 
4087514
Stability:
Hygroscopic
InChIKey
IYGXEHDCSOYNKY-RZHHZEQLSA-N
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Safety

Hazard Codes 
T
Risk Statements 
60-22
Safety Statements 
53-45
WGK Germany 
3
RTECS 
UK8025000
8-10
HS Code 
2937500000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0424
Product name
Prostaglandin F2α tris salt
Purity
≥99%, synthetic, powder
Packaging
1mg
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
1213001
Product name
Dinoprost tromethamine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1396
Updated
2024/03/01
Alfa Aesar
Product number
J67245
Product name
Prostaglandin F2alpha tris salt, 99%
Packaging
1mg
Price
$69.9
Updated
2023/06/20
Alfa Aesar
Product number
J67245
Product name
Prostaglandin F2alpha tris salt, 99%
Packaging
5mg
Price
$283
Updated
2023/06/20
Cayman Chemical
Product number
16020
Product name
Prostaglandin F2α (tromethamine salt)
Purity
≥99%
Packaging
1mg
Price
$33
Updated
2024/03/01
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Dinoprost tromethamine Chemical Properties,Usage,Production

Description

Dinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs.

Chemical Properties

White Solid

Originator

Prostin F2A,Upjohn,UK,1972

Uses

One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.

Indications

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

Definition

dinoprost tromethamine is a synthetic analogue of the naturally occurring prostaglandin F2 alpha. Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.

Manufacturing Process

A solution of tris(hydroxymethyl)aminomethane (1.645 grams) in 3.0 ml of water at 60°C is added with vigorous stirring to a solution of PGF2α, (5.00 grams) in 700 ml of acetonitrile which has just been
ought to its boiling point. The vessel which contained the aqueous amine solution is rinsed with three 0.66 ml portions of water, each rinsing being added with vigorous stirring to the acetonitrile solution. The mixture is then cooled to 25°C by immersion of the vessel in cool water. At the cloud point, the vessel wall (glass) below the liquid surface is scratched vigorously with a glass rod. The mixture is then maintained at 25°C for 24 hours.
The resulting crystals are collected by filtration under nitrogen, washed on the filter with 50 ml of acetonitrile, and then dried by passing nitrogen at 50°C through the filter cake for one hour. Drying is completed in an oven at 70°C for 8 hours to give 5.965 grams of the tris(hydroxymethyl)aminomethane salt of PGF2α in free flowing crystalline form; MP 100°-101°C.

brand name

Prostin F2 Alpha (Pharmacia & Upjohn).

Therapeutic Function

Smooth muscle stimulant

Biochem/physiol Actions

Prostaglandin F2α is induced by uterine-produced oxytocin and acts on the corpus luteum to cause luteolysis and inhibit progesterone production.

Safety Profile

Poison by intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Human reproductive effects by intervagmal route: terminates pregnancy, effects on fertility. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also other prostaglandin entries.

storage

Store at -20°C

Dinoprost tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Dinoprost tromethamine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Wuhan Sunrise Technology Development Co., Ltd.
Tel
27-027-83314682 13554138826
Fax
+86 (27) 8331-4682
Email
whsrtech@vip.163.com
Country
China
ProdList
249
Advantage
62
Shanghai Bioman Pharma Limited
Tel
21-33738120 15000110506
Fax
021-23025272
Email
info@bioman.com.cn
Country
China
ProdList
61
Advantage
62
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
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View Lastest Price from Dinoprost tromethamine manufacturers

Sinoway Industrial co., ltd.
Product
Dinoprost Tromethamine 38562-01-5
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
EP9.0, GMP, DMF
Supply Ability
20 tons
Release date
2024-06-27
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Dinoprost tromethamine 38562-01-5
Price
US $15.00/gram
Min. Order
10gram
Purity
99%
Supply Ability
50000 kilograms
Release date
2022-11-18
Nantong Guangyuan Chemicl Co,Ltd
Product
Dinoprost 38562-01-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-10-18

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