Candicidin
- Product Name
- Candicidin
- CAS No.
- 1403-17-4
- Chemical Name
- Candicidin
- Synonyms
- candimon;NSC94219;CARBOPRST;candeptin;Levorinum;NSC 94219;NSC-94219;candicidin;Canitracin;candizidin
- CBNumber
- CB6501392
- Molecular Formula
- C21H36O5
- Formula Weight
- 368.51
- MOL File
- 1403-17-4.mol
Candicidin Property
- Boiling point:
- 878.79°C (rough estimate)
- Density
- 1.1100 (rough estimate)
- refractive index
- 1.6200 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO:4.9(Max Conc. mg/mL);10.08(Max Conc. mM)
Ethanol:12.5(Max Conc. mg/mL);25.72(Max Conc. mM) - form
- A solid
- Water Solubility
- 13.47g/L(21 ºC)
Safety
- Toxicity
- LD50 i.p. in mice: 14 mg/kg (Vining)
N-Bromosuccinimide Price
- Product number
- 26708
- Product name
- Levorin Complex
- Packaging
- 1mg
- Price
- $335
- Updated
- 2024/03/01
- Product number
- 26708
- Product name
- Levorin Complex
- Packaging
- 5mg
- Price
- $1169
- Updated
- 2024/03/01
- Product number
- V1816
- Product name
- Candicidin
- Packaging
- 5mg
- Price
- $1400
- Updated
- 2021/12/16
- Product number
- V1816
- Product name
- Candicidin
- Packaging
- 1mg
- Price
- $471
- Updated
- 2021/12/16
- Product number
- 68510
- Product name
- Candicidin
- Packaging
- 10mg
- Price
- $610
- Updated
- 2021/12/16
Candicidin Chemical Properties,Usage,Production
Originator
Candeptin,Schmidt,US,1964
Uses
Candicidin is a macrocyclic heptaene antifungal complex produced by Streptomyces griseus and isolated by Lechevalier and colleagues in 1953. The candicidin complex comprises analogues A, B, C and D, with candicidin D as the major component. Candicidin is active against fungi, in particular Candida albicans, and is used clinically to treat vaginal candidiasis. Like all polyene antifungal metabolites, candicidin acts by binding to ergosterol and disrupting the fungal membrane.
Definition
ChEBI: Candicidin D is a 38-membered ring lactone containing seven (E)-double bonds between positions 22 and 35 and substituted by hydroxy groups at positions 9, 11, 13, 17 and 19, oxo groups at positions 3, 7 and 15, a carboxy group at position 18, a 3-amino-3,6-dideoxymannopyranosyloxy group at position 21, a methyl group at position 36 and a 7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl group at position 37. It is the major component of candicidin, a mixture of antifungal heptaene macrolides obtained from a strain of Streptomyces griseus. It has a role as a bacterial metabolite and an antifungal drug. It is a macrolide antibiotic and a polyene antibiotic.
Manufacturing Process
Hubert Lechevalier et al were the first to describe "Candicidin, a New
Antifungal Antibiotic," in Mycologia XLV, No. 2, 155-171, March-April 1953.
They produced candicidin by growing a culture of the organism streptomyces
griseus No. 3570 on a yeast-glucose medium, isolating a "crude candicidin"
from the resulting broth and purifying it. An improved extraction and
purification method is described in US Patent 2,872,373 and is shown in the
flow diagram below.
Another extraction and separation process is described in US Patent
2,992,162.
brand name
Vanobid (Sanofi Aventis).
Therapeutic Function
Topical antifungal
Candicidin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Candicidin manufacturers
- Product
- Candicidin
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-22