ChemicalBook > CAS DataBase List > Atomoxetine hydrochloride

Atomoxetine hydrochloride

Product Name
Atomoxetine hydrochloride
CAS No.
82248-59-7
Chemical Name
Atomoxetine hydrochloride
Synonyms
ATOMOXETINE;Strattera;ATOMOXETINE HCL;ATOMOXITINE;Atomoxetine HCI;LY 139603;LY 139603 HCl;Atazanavir HCl;Atomoxitine HCL;(R)-Atomoxetine HCl
CBNumber
CB5757860
Molecular Formula
C17H22ClNO
Formula Weight
291.82
MOL File
82248-59-7.mol
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Atomoxetine hydrochloride Property

Melting point:
167-169°C
alpha 
D25 -38.01°; 36525 -177.26° (c = 1 in methanol); D23 -41.37° (c = 1.02 in methanol); D25 -40.3° (c = 0.94 in ethanol)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
solid
pka
10.13(at 25℃)
color 
White to Almost white
Water Solubility 
Soluble to 50 mM in water with gentle warming
Merck 
14,863
BCS Class
1?
InChI
InChI=1/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/s3
InChIKey
LUCXVPAZUDVVBT-UNTBIKODSA-N
SMILES
O([C@H](CCNC)C1C=CC=CC=1)C1=CC=CC=C1C.Cl |&1:1,r|
CAS DataBase Reference
82248-59-7(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
22-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A-095
Product name
Atomoxetine hydrochloride solution
Purity
1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$183
Updated
2024/03/01
TCI Chemical
Product number
A2357
Product name
Atomoxetine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$90
Updated
2024/03/01
TCI Chemical
Product number
A2357
Product name
Atomoxetine Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$511
Updated
2024/03/01
Cayman Chemical
Product number
22248
Product name
Atomoxetine (hydrochloride)
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
22248
Product name
Atomoxetine (hydrochloride)
Packaging
50mg
Price
$431
Updated
2024/03/01
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Atomoxetine hydrochloride Chemical Properties,Usage,Production

Description

Atomoxetine is the first non-stimulant marketed for the treatment of attention deficit hyperactivity disorder (ADHD). It is the R-stereoisomer of the racemate tomoxetine and is a selective and potent norepinephrine uptake inhibitor (Ki=0.7–1.9 nM) that is devoid of binding to monoamine receptor. It also has little effect on dopamine and serotonin reuptake or acetylcholine, H1 histamine, alpha1 or alpha1-adrenergic or dopamine receptors. It is prepared from racemic 1-phenylbut-3-en-1-ol via a selective enzymatic acylation leaving the desired S-stereoisomer as the alcohol. This alcohol is converted via a Mitsunobu reaction with ortho-cresol to the corresponding ether with isomeric R-configuration. Ozonolysis and reduction steps provided the terminal alcohol that is mesylated and displaced with methylamine. Its selectivity for norepinephrine relative to dopamine inhibition was demonstrated in vivo preclinically. In a two-lever (two condition) discriminative stimulus effect study in squirrel monkeys, tomoxetine and other norepinephrine uptake inhibitors substituted for cocaine under low-dose training conditions, whereas dopamine uptake inhibitors substituted for cocaine in both low and high-dose conditions. In clinical ADHD studies in adolescents, it was significantly different from placebo in 1.2 and 1.8 mpk/day dosing. In the clinical study in adults using the CAARS scale a 95 mg/day dose provided greater than 30% improvement in total scores. Atomoxetine is about 63% orally bioavailable, is highly protein bound (98%, primarily to albumin) and has a half-life of about 5.2 h. It is metabolized by CYP2D6 resulting in differential clearance for poor metabolizers (halflife of 19 h with a 10 times higher AUC) relative to extensive metabolizers. The total daily dose for children, adolescents and adults is a maximum of 100 mg/day. Common side effects in children and adults include nausea, decreased appetite, and dizziness. Adults may also have insomnia.

Description

Atomoxetine is a selective norepinephrine reuptake inhibitor with Ki values of 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively. It is selective over the choline, GABA, and adenosine transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides. In the rat prefrontal cortex (PFC), it increases extracellular norepinephrine and dopamine by 3-fold and increases Fos expression. Atomoxetine (0.1, 0.5, and 1 mg/kg) reduces premature responding, a measure of impulsivity, by rats in the 5-choice serial reaction time test (5CSRTT) in a dose-dependent manner. It also has neuroprotective effects when administered prior to ischemic damage in a gerbil model of transient cerebral ischemia. Formulations containing atomoxetine have been used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults.

Chemical Properties

White Solid

Originator

Eli Lilly & Co (US)

Uses

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

  • to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
  • to study its effects on set shifting in rats
  • to study its effects on rat brain as a result of its long-term use

Uses

Atomoxetine hydrochloride, a Norepinephrine reuptake inhibitor, is used as a Psychotherapeutic and anti-depressant. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications, including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Atomoxetine hydrochloride may be used as a pharmaceutical reference standard for determining atomoxetine hydrochloride in pharmaceutical formulations by spectrophotometric method.

Definition

ChEBI: The hydrochloride salt of atomoxetine.

brand name

Strattera (Lilly).

General Description

Atomoxetine hydrochloride is a nonstimulant used in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children and adults.

Biological Activity

Potent and selective noradrenalin re-uptake inhibitor (K i values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (K i > 1 μ M). Antidepressant.

Biochem/physiol Actions

Norepinephrine uptake blocker.

Synthesis

The 3-aryloxy substituent was introduced utilizing a chiral alcohol by either the Mitsunobu reaction or by nucleophilic aromatic displacement. Because of the expense and difficulty of the Mitsunobu reaction on large scale, the commercial process adopts the nucleophilic aromatic substitution method. 3- Chloropropiophenone (37) was asymmetrically reduced with borane and catalytic amount of (S)-oxazaborolidine (8) in THF at 0??C to give chiral alcohol 38 in 99% yield and 94% e.e. The chiral alcohol was further purified by recrystallization to greater than 99% e.e.. Subsequent treatment of chloride 38 with excess dimethylamine (40% in water) in ethanol gave dimethylamine alcohol 39 in 90% yield. Alcohol 39 was then subjected to nucleophilic aromatic displacement in the presence of NaH in DMSO with 1- fluoro-2-(t-butylimino)benzene (41), which was prepared in high yield from 2-fluorobenzaldehyde (40). The displacement product 42 was obtained in 98% yield, and the imine 42 was subsequently hydrolyzed with acetic acid in water at low temperature to give the corresponding aldehyde 43 in 96% yield. Sodium borohydride was employed to reduce aldehyde 43 to alcohol in cold methanol and the intermediate alcohol was converted to chloride 44 with thionyl chloride. Chloride 44 was then reduced with zinc metal under acidic conditions to give methyl adduct 45 in 95% yield and 94% e.e. Finally, phenyl chloroformate and triethylamine was used to transform dimethylamine 45 to monomethyl amine, which was subsequently treated with HCl in EtOAc under reflux to give atomoxetine hydrochloride (IV) in 98% yield and 99% e.e. from 45.

storage

Store at RT

Clinical claims and research

Atomoxetine hydrochloride was assessed in four randomized, double-blind, placebo-controlled studies involving 759 paediatric patients (ages 6 to 18 years old) who met the Diagnostic and Statistical Manual 4th edition (DSM-IV) criteria for ADHD. Signs and symptoms of ADHD were evaluated by a comparison of mean change from baseline to endpoint for atomoxetine hydrochloride-treated and placebo-treated patients using an intent-to-treat analysis of the primary outcome measure, the investigator-administered and -scored ADHD Rating Scale-IV-Parent Version (ADHDRS) total score. In all four trials, which lasted six to nine weeks, improvements in ADHD symptoms were significantly superior in patients receiving atomoxetine hydrochloride compared with those receiving placebo. Atomoxetine hydrochloride was also studied in two randomized, double-blind, placebo-controlled studies involving 536 adult patients who met DSM-IV criteria for ADHD. Signs and symptoms were evaluated using the investigator-administered Conners Adult ADHD Rating Scale Screening Version (CAARS). In both studies, which lasted ten weeks, ADHD symptoms were significantly improved in those patients receiving atomoxetine hydrochloride[1].

References

[1] Melissa Garland, Peter Kirkpatrick. “Atomoxetine hydrochloride.” Nature Reviews. Drug Discovery 3 5 (2004): 385–386.

Atomoxetine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Atomoxetine hydrochloride manufacturers

Sinoway Industrial co., ltd.
Product
Atomoxetine Hydrochloride 82248-59-7
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-07-21
Baoji Guokang Bio-Technology Co., Ltd.
Product
Atomoxetine hydrochloride 82248-59-7
Price
US $1365.00/Kg/Bag
Min. Order
1KG
Purity
99
Supply Ability
1T
Release date
2021-06-04
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Atomoxetine Hydrochloride 82248-59-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
1000 kgs
Release date
2024-05-17

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