Appearance Properties Pharmacological effects Indications Usage and dosage Combination therapy Detection Indicator Precautions Uses
ChemicalBook > CAS DataBase List > Disodium phosphonomycin

Disodium phosphonomycin

Appearance Properties Pharmacological effects Indications Usage and dosage Combination therapy Detection Indicator Precautions Uses
Product Name
Disodium phosphonomycin
CAS No.
26016-99-9
Chemical Name
Disodium phosphonomycin
Synonyms
Fosfomycin sodium;PHOSPHOMYCIN DISODIUM;FOSFOMYCIN DISODIUM SALT;PHOSPHOMYCIN DISODIUM SALT;2S)-1;fom-na;Fosfocin;FosfoMyci;Forocyle S;Fosmicin S
CBNumber
CB5761937
Molecular Formula
C3H8NaO4P
Formula Weight
162.06
MOL File
26016-99-9.mol
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Disodium phosphonomycin Property

Melting point:
>300°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
Solid
color 
White to Off-White
Water Solubility 
Freely soluble in water or aqueous solution
BRN 
4604425
Stability:
Hygroscopic
InChIKey
QZIQJIKUVJMTDG-OTUWWBTESA-L
CAS DataBase Reference
26016-99-9(CAS DataBase Reference)
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Safety

Hazard Codes 
F,C
Risk Statements 
11-34
Safety Statements 
16-26-36/37/39-45
WGK Germany 
2
RTECS 
SZ7902000
F 
10-21
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P5396
Product name
Phosphomycin disodium salt
Purity
antibacterial MurA inhibitor
Packaging
1g
Price
$44.7
Updated
2024/03/01
Sigma-Aldrich
Product number
34089
Product name
Fosfomycin sodium
Purity
VETRANAL
Packaging
100mg
Price
$206
Updated
2024/03/01
TCI Chemical
Product number
F0889
Product name
Fosfomycin Disodium Salt
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$91
Updated
2024/03/01
TCI Chemical
Product number
F0889
Product name
Fosfomycin Disodium Salt
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$301
Updated
2024/03/01
Alfa Aesar
Product number
J66602
Product name
Fosfomycin disodium
Purity
90%
Packaging
1g
Price
$37.1
Updated
2024/03/01
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Disodium phosphonomycin Chemical Properties,Usage,Production

Appearance Properties

It appears as a white crystalline powder at room temperature, hygroscopic, easily soluble in water, heated while dissolving.
Fosfomycin Sodium can combine with a bacterial cell wall synthesis enzyme, hinder bacterial cell wall synthesis related substances utilizing at the first reaction, which in turn has a bactericidal effect. have antibacterial effect for Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Proteus mirabilis, Salmonella typhi, Serratia bacteria, most Pseudomonas aeruginosa, Streptococcus pyogenes, Streptococcus faecalis, part indole-positive Proteus and certain Klebsiella, Enterobacter bacteria. The main clinical applications of Fosfomycin Sodium include: urinary tract treatment of sensitive Gram-negative bacteria caused urinary system, infection of skin and soft tissue, respiratory, intestinal and other parts. It can also be combined with other antibiotics, the treatment of severe infections caused by susceptible strains such as sepsis, pulmonary, meningeal infections, peritonitis, adnexitis, intrauterine infections, pelvic inflammatory disease, osteomyelitis. Also in combination with vancomycin for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection.

Pharmacological effects

1. Broad spectrum antibiotic, high bioavailability, rapid absorption, strong anti-bacterial, not diet affected. Fosfomycin Sodium displays effects on killing Gram-positive and Gram-negative bacteria, especially Pseudomonas aeruginosa, Proteus, Salmonella, and exhibit excellent antibacterial activity for a variety of drug-resistant Staphylococcus aureus and Escherichia coli. For usage in animals, there is no drug resistance and cross-resistance. Clinical effect is good.
2. Rapid sterilization: This product is a rapid fungicide, its role is still evident after 1-2 hours. About 25% of the E. coli were killed at 1 hour after exposured to Fosfomycin Sodium (12.5μg/ml), and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also all killed at 4 and 8 hours.
3. Low toxicity, little irritation on the body, no acute toxicity and adverse reactions, no increased burden on the kidney.
4. Low residue: the eliminate time for the muscles and organs to reach the residual standard is 48-72 hours.
The above information is edited by the Chemicalbook of Tian Ye.

Indications

Mainly used for Staphylococcus aureus, streptococcus, E. coli, Salmonella and other gram-negative bacteria caused acute and chronic bowel disease treatment in chickens, ducks, pigs.

Usage and dosage

Used in water for livestock and poultry: every 100kg of water added the product 5-10 grams, 2 times a day, once every three days. Used in animal spices: 10-15 g of the product added to per 100kg feed, 2 times a day, once every three days.

Combination therapy

For the treatment of intestinal infections, Fosfomycin Sodium can combine with β-lactam, aminoglycoside.
For the treatment of respiratory and lung infections, combining with macrolides, β-lactam.
For staph infections, better combined with erythromycin, rifampin.
For the treatment of acute respiratory infections, sepsis, peritonitis ect., increase the dose. Need to combine with β-lactams or aminoglycosides.

Detection Indicator

No. Test item Export standard CP2000 Edition
1 Traits: A white crystalline powder, odorless, taste salty white crystalline powder, odorless, salty taste
2 Discriminator: Positive reaction Positive reaction
3 Specific rotation °-4.2 ~-5.5-4.2 ~-5.5
4 Heavy Metal ≤0.0010% 0≤.0010%
5 Content ≥700μ/mg ≥700μ/mg
6 Alkalinity 9.0-10.5 9.0-10.5
7 Weight loss on drying ≤1.0% ≤1.5% (water)
8 Solution clarity ≤No. 3/4 turbidity standards solution ≤No. 1 turbidity standard solution
9 Color of the solution ≤Yellow No. 1 ≤ Yellow No. 1
10 Glycols ≤0.50% ≤0.50%
11 Clarity of solution: can not be detected, in compliance with (a gross point ≤8/g, wherein a color point ≤2/g)
12 W ≤0.002%-
13 phosphorus content-16.2-17.9%
14 Sterile: Subject to compliance
15 Heat source/ bacterial endotoxin: compliance (heat source) compliance (bacterial endotoxin)
16 α-phenylethylamine ≤0.01%-
17 Residual amount of methanol: real
18 Residual amount of ethanol: Real
The above information is the main export detection index of fosfomycin.

Precautions

1. This product is mainly used for pigs, chickens, fish; application for other animals should medication under veterinary guidance.
2. Fosfomycin Sodiumand β-lactams, aminoglycosides, macrocyclic acid esters have a synergistic effect of combination therapy, and can reduce or delay the occurrence of bacterial resistance.

Uses

For the treatment of infections caused by Staphylococcus aureus, Escherichia coli, Proteus and Shigella.

Chemical Properties

White Solid

Uses

Curariform muscle relaxants

Uses

Prevents peptidoglycan synthesis by inhibiting MurA, an enzyme responsible for synthesizing N-acetylmuramic acid or NAM, a major component of peptidoglycan

Uses

Disodium phosphonomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine

Disodium phosphonomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Disodium phosphonomycin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Disodium phosphonomycin 26016-99-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
95%-101%;EP
Supply Ability
1000KGS
Release date
2021-06-23
Hebei ZB Gamay Biological Technology Co.,Ltd
Product
Fosfomvcin Sodium 26016-99-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
700U/mg
Supply Ability
1000kg
Release date
2022-12-22
airuikechemical co., ltd.
Product
Disodium phosphonomycin 26016-99-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20tons
Release date
2024-04-07

26016-99-9, Disodium phosphonomycinRelated Search:

Sodium chloride Fosfomycin Folic acid Ethylenediaminetetraacetic acid disodium salt Ethyl 2-(Chlorosulfonyl)acetate Glycine Sodium Monofluorophosphate Metronidazole Penicillin G sodium salt Colistin sulfate Gentamicin sulfate PotassiuM sodiuM Dehydroandrographolide Succinate Phosphomycin calcium salt Phosphonic acid, disodium salt PhosphonoMethanol FOSMIDOMYCIN, SODIUM SALT Disodium phosphonomycin phosphoric acid

  • [(2R,3S)-3-Methyloxiran-2-yl]phosphonic acid disodium salt
  • Fosfomycin sodium
  • disodium [(2R,3S)-3-methyloxiran-2-yl]-bis(oxidanidyl)-oxo-$l^{5}-phosphane
  • disodium [(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-$l^{5}-phosphane
  • disodium keto-[(2R,3S)-3-methyloxiran-2-yl]-dioxido-phosphorane
  • Sodium ((2S,3R)-3-methyloxiran-2-yl)phosphonate
  • 2S)-1
  • (1,2-epoxypropyl)-,disodiumsalt(1r,2s)(-)-phosphonicaci
  • (2r-cis)-(3-methyloxiranyl)phosphonicaciddisodiumsalt
  • (3-methyloxiranyl)-,disodiumsalt,(2r-cis)-phosphonicaci
  • (-)-(1R,2S)-(1,2-EPOXYPROPYL)PHOSPHONIC ACID DISODIUM SALT
  • (-)-(1R,2S)-(1,2-EPOXYPROPYL)PHOSPHONIC ACID
  • Forocyle S
  • Fosfocin
  • Fosmicin S
  • NSC 136017
  • Phosphonic acid, (1,2-epoxypropyl)-, disodium salt, (1R,2S)-(-)- (8CI)
  • Phosphonic acid, (3-methyloxiranyl)-, disodium salt, (2R-cis)-
  • Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, disodium salt
  • PHOSPHONOMYCIN DISODIUM SALT
  • PHOSPHOMYCIN DISODIUM
  • PHOSPHOMYCIN DISODIUM SALT
  • disodium (1R,2S)-(1,2-epoxypropyl)phosphonate
  • PHOSPHOMYCIN 2NA
  • (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin
  • (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphomycin disodium salt, Phosphonomycin
  • [(2R)-3α-Methyloxirane-2α-yl]phosphonic acid disodium salt
  • Fosfomvcin Sodium
  • Fosphomycin disodium salt, 98%
  • disodiumfosfomycin
  • fom-na
  • fosfomycindisodium
  • fosfomycinsodiumsalt
  • phosphonomycinsodium
  • sodiumfosfomycin
  • disodium phosphonomycin
  • FOSFOMYCIN DISODIUM SALT
  • disodium (3-methyl-2-oxiranyl)-dioxido-oxophosphorane
  • Fosfomycin Sodium for Injection
  • Phosphonemycin Disodium
  • FosfomycinDisodiumSalt&gt
  • Fosfomycin Salt
  • Fosfomycin Sodium Standard
  • FosfoMyci
  • Phosphomycin sodium/Fosfomycin sodium powder
  • Disodium phosphonomycin USP/EP/BP
  • Fosphomycin Sodium/Disodium phosphonomycin
  • Phosphomycin Disodium Salt (Fosfomycin Disodium Salt) extrapure, 99%
  • disodium [(2S,3R)-3-methyloxiran-2-yl]phosphonate
  • FosfomycinDisodiumSal
  • ((2R,3S)-3-Methyloxiran-2-yl)phosphonic acid, disodium salt (Fosfomycin Impurity)
  • Sodium ((2R,3S)-3-methyloxiran-2-yl)phosphonate
  • Fosfomycin Disodium Salt, ≥ 98.0%
  • 26016-99-9
  • 26016-99-6
  • C3H7O4PNa
  • C3H5Na2O4P
  • C3H5O4PNa2