4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER

Product Name: 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
CAS No.: 191102-87-1
Chemical Name: 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER
Synonyms: GGTI-2147;GGTI-2147 (GGTI2147);TUQRZGWNDBXSNP-SANMLTNESA-N;Geranylgeranyl transferase inhibitor-2147;4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER;L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester
CBNumber: CB5766770
Molecular Formula: C28H30N4O3
Formula Weight: 470.56
MOL File: Mol file

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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Property

Boiling point:: 710.6±60.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO
pka: 13.22±0.46(Predicted)
form: Solid
Sensitive: Light Sensitive & Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 345885
Product name: GGTI-2147 - CAS 191102-87-1 - Calbiochem
Purity: A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).
Packaging: 250μG
Price: $245
Updated: 2024/03/01

Alfa Aesar

Product number: J65022
Product name: GGTI-2147
Packaging: 100microg
Price: $591
Updated: 2021/12/16

TRC

Product number: G368900
Product name: GGTI-2147
Packaging: 5mg
Price: $1470
Updated: 2021/12/16

TRC

Product number: G368900
Product name: GGTI-2147
Packaging: 0.1mg
Price: $115
Updated: 2021/12/16

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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Chemical Properties,Usage,Production

Uses

GGTI-2147 is an inhibitors of protein geranylgeranyltransferase-I and protein prenylation. Increases prelamin A accumulation by inhibiting ZMPSTE24 protein in human fibroblast and increases cytosolic accumulation of Rac1 and elicites significant inhibition of GSIS from INS 832/13 cells.

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER Suppliers

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191102-87-1, 4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTERRelated Search:

GGTI-2147

4-[[N-(IMIDAZOL-4-YL)METHYLENEAMINO]-2-(1-NAPHTHYL)BENZOYL]LEUCINE METHYL ESTER

TUQRZGWNDBXSNP-SANMLTNESA-N

GGTI-2147 (GGTI2147)

L-Leucine, N-[4-[(1H-imidazol-5-ylmethyl)amino]-2-(1-naphthalenyl)benzoyl]-, methyl ester

Geranylgeranyl transferase inhibitor-2147

191102-87-1

A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).

Amino Acids & Derivatives, Chiral Reagents, Heterocycles, Inhibitors

Other enzyme inhibitors and activators