ChemicalBook > CAS DataBase List > 4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE

4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE

Product Name
4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE
CAS No.
162401-70-9
Chemical Name
4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE
Synonyms
AKOS B014002;AKOS BBS-00006582;TIMTEC-BB SBB009330;ART-CHEM-BB B014002;ASINEX-REAG BAS 11524503;4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE;3-Methoxy-4-(difluoromethoxy)benzaldehyde;Benzaldehyde,4-(difluoroMethoxy)-3-Methoxy-;4-(DIFLUOROMETHOXY)-3-METHOXYBENZALDEHYDE, 98% MIN.
CBNumber
CB5767515
Molecular Formula
C9H8F2O3
Formula Weight
202.15
MOL File
162401-70-9.mol
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4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE Property

Boiling point:
105-106°C 1mm
Density 
1.260±0.06 g/cm3(Predicted)
refractive index 
1.5155
storage temp. 
Inert atmosphere,2-8°C
form 
liquid
color 
Clear, light orange
Sensitive 
Air Sensitive
InChI
InChI=1S/C9H8F2O3/c1-13-8-4-6(5-12)2-3-7(8)14-9(10)11/h2-5,9H,1H3
InChIKey
KGPOVKAYCXTCQS-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(OC(F)F)C(OC)=C1
CAS DataBase Reference
162401-70-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
D445208
Product name
4-(Difluoromethoxy)-3-methoxybenzaldehyde
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
D445208
Product name
4-(Difluoromethoxy)-3-methoxybenzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J96783
Product name
4-Difluoromethoxy-3-methoxybenzaldehyde
Packaging
10g
Price
$102
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-3-11
Product name
4-(Difluoromethoxy)-3-methoxybenzaldehyde
Purity
98%
Packaging
1g
Price
$55
Updated
2021/12/16
AK Scientific
Product number
J96783
Product name
4-Difluoromethoxy-3-methoxybenzaldehyde
Packaging
1g
Price
$22
Updated
2021/12/16
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4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

75-45-6

121-33-5

162401-70-9

1. DMF (450 mL), vanillin (30.0 g, 0.2 mol) and sodium hydroxide (13.0 g, 0.325 mol) were added to a reaction flask. 2. The reaction system was warmed to 90 °C with continuous stirring for 2 hours. 3. Monochlorodifluoromethane gas was introduced into the reaction system and the reaction progress was monitored by TLC until the vanillin was completely consumed. 4. Upon completion of the reaction, the heating was stopped and the reaction system was cooled to room temperature. 5. The reaction was quenched by addition of water (450 mL) and the reaction mixture was extracted with dichloromethane. 6. The organic phase was washed sequentially with saturated sodium carbonate solution and saturated brine, then dried over anhydrous sodium sulfate. 7. Concentrate the organic phase under pressure to obtain a light yellow oil 3-methoxy-4-(difluoromethoxy)benzaldehyde (31.9 g, 80% yield, 99.2% purity, HPLC chromatogram in Fig. 1), which can be used in subsequent steps without further purification.

References

[1] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 727 - 730
[2] Patent: CN106883118, 2017, A. Location in patent: Paragraph 0038-0042

4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE Suppliers

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View Lastest Price from 4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE 162401-70-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Honest Joy Holdings Limited
Product
4-Difluoromethoxy-3-Methoxy-Benzaldehyde 162401-70-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99.4%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE 162401-70-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2018-12-25

162401-70-9, 4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDERelated Search:

Roflumilast 4-DIFLUOROMETHOXY-3-ETHOXY-BENZOIC ACID HYDRAZIDE 4-DIFLUOROMETHOXY-3-METHOXY-BENZOIC ACID 4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE 4-(DIFLUOROMETHOXY)-3,5-DIMETHOXYBENZALDEHYDE 4-(Difluoromethoxy)-3-methoxybenzamide 1-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-4,4,4-TRIFLUORO-BUTANE-1,3-DIONE 4-DIFLUOROMETHOXY-3-ETHOXY-BENZOIC ACID 4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE OXIME 2-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE 1-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-ETHANONE 4-DIFLUOROMETHOXY-3-METHOXY-BENZOIC ACID METHYL ESTER AKOS B024970 4-DIFLUOROMETHOXY-3-METHOXY-BENZOIC ACID HYDRAZIDE [[4-(DIFLUOROMETHOXY)-3-METHOXYBENZOYL]AMINO]ACETIC ACID RARECHEM AL BF 0521 RARECHEM AL BI 0521 2-BROMO-1-[4-(DIFLUOROMETHOXY)-3-METHOXYPHENYL]ETHANONE

  • 3-Methoxy-4-(difluoromethoxy)benzaldehyde
  • ASINEX-REAG BAS 11524503
  • ART-CHEM-BB B014002
  • AKOS B014002
  • AKOS BBS-00006582
  • 4-DIFLUOROMETHOXY-3-METHOXY-BENZALDEHYDE
  • Benzaldehyde,4-(difluoroMethoxy)-3-Methoxy-
  • TIMTEC-BB SBB009330
  • 4-(DIFLUOROMETHOXY)-3-METHOXYBENZALDEHYDE, 98% MIN.
  • 162401-70-9
  • Fluorine series