3-ETHOXY-3-OXOPROPYLZINC BROMIDE Property

Density 

0.972 g/mL at 25 °C

Flash point:

1 °F

storage temp. 

2-8°C

Water Solubility 

Reacts with water.

Exposure limits

ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)

Safety

Hazard Codes 

F,Xi,Xn

Risk Statements 

11-19-36/37-40

Safety Statements 

16-26-29-33-36/37

RIDADR 

UN 3399 4.3/PG 2

WGK Germany 

1

HazardClass 

4.3

PackingGroup 

II

HS Code 

29319090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H261In contact with water releases flammable gas

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H333May be harmful if inhaled

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

3-ETHOXY-3-OXOPROPYLZINC BROMIDE Chemical Properties,Usage,Production

Uses

3-Ethoxy-3-oxopropylzinc bromide is a reagent used to insert ethyl propanoate group to the substrate. It can be used in:

• Synthesis of γ-keto esters from aryl chlorides.
• Synthesis of sulfones from 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) (DABSO) and alkyl halides.
• Negishi cross-couplings with aryl vinyl phosphates to synthesize 1,1-disubstituted alkenes.